| Sereno's Home Renovators Ltd | Construction | 2026 |
| Sergio Quartz Limited | Manufacturing | 2024 |
| Sern Investments Limited | Real estate | 2022 |
| Sertal Limited | Other services | 2017 |
| Servana Managed Services Ltd | Information & communication | 2017 |
| Service 4 YOU Ltd | Construction | 2017 |
| Service Break Ltd | Information & communication | 2025 |
| Service-U-Right Limited | Wholesale & retail | 2003 |
| Servicetech Limited | Professional & scientific | 2010 |
| Servlet Ltd | Administrative & support | 2018 |
| SET Accountancy Ltd | Professional & scientific | 2023 |
| SET Business Technologies Ltd | Wholesale & retail | 2024 |
| SET Connect LDN Ltd | Administrative & support | 2021 |
| SET Modeling Limited | Professional & scientific | 2026 |
| Sevarg Limited | Financial services | 2012 |
| Seven Days Food Ltd | Wholesale & retail | 2023 |
| Seventa Events Limited | Hospitality | 2017 |
| SEW Eco Fabrics Ltd | Wholesale & retail | 2022 |
| SEW Lovely Jubbly Limited | Education | 2025 |
| Sfbb Limited | Professional & scientific | 2021 |
| SFP Services Ltd | Professional & scientific | 2000 |
| SFR Homes & Solutions Limited | Administrative & support | 2024 |
| SG (UK) Mortgages Ltd | Financial services | 2024 |
| SG Financial Limited | Professional & scientific | 2018 |
| SG PMU & Aesthetics Limited | Other services | 2026 |
| SG Prime Ltd | Construction | 2019 |
| SGT Care Ltd | Health & social care | 2023 |
| SH Accounting Solutions Ltd | Professional & scientific | 2019 |
| Shadbolt Property Limited | Real estate | 2016 |
| Shadok Global Ltd | Information & communication | 2025 |
| Shadow Customs Limited | Wholesale & retail | 2017 |
| Shadowcollects Limited | Wholesale & retail | 2025 |
| Shadows Professional Development Limited | Education | 2008 |
| Shaftesbury Homes & Arethusa | Health & social care | 1904 |
| Shaftesbury House (Gosport) Residents Management Company Limited | Households | 2025 |
| Shagor Catering Ltd | Hospitality | 2009 |
| Shah Trading Group Ltd | Wholesale & retail | 2025 |
| Shahad & Sophie Property Ltd | Real estate | 2021 |
| Shakeaway Worldwide Holdings Ltd | Wholesale & retail | 2017 |
| Shaker Kitchens Ltd | Wholesale & retail | 2025 |
| Shamak Solution Limited | Construction | 2026 |
| Shami Ltd. | Hospitality | 2017 |
| Shamrock Limited | Households | 1979 |
| Shan Pro World 01 Ltd | Wholesale & retail | 2025 |
| Shang PIN BH8 Ltd | Hospitality | 2023 |
| Share With a Bear Ltd | Wholesale & retail | 2016 |
| Shareland Investments Limited | Real estate | 1995 |
| Sharemore Limited | Information & communication | 2024 |
| Shark Helmets UK Ltd | Wholesale & retail | 2005 |
| Sharkey's Entertainment Limited | Hospitality | 2012 |
| Sharman and Company Developments Limited | Construction | 2023 |
| Sharman Properties Ltd | Construction | 2017 |
| Sharp Hair Studio Ltd | Other services | 2019 |
| Sharp Logistics 247 Limited | Transport & logistics | 2021 |
| Sharp Practice (Salisbury) Limited | Wholesale & retail | 2003 |
| Sharp Roofing and Solar Ltd | Construction | 2025 |
| Shaun Davis Construction Ltd | Construction | 2017 |
| Shaw Decor Spray Finishing Ltd | Construction | 2021 |
| Shaw Lodge (Bournemouth) RTM Company Limited | Households | 2025 |
| Shawarmax Limited | Hospitality | 2026 |
| Shawn Oak Landscapes Ltd | Administrative & support | 2013 |
| Shearing Electrical Limited | Construction | 2001 |
| Sheila Robinson & Co Ltd | Information & communication | 2014 |
| Sheilena AI Ltd | Professional & scientific | 2024 |
| Shel.Gd Ltd | Extraterritorial | 2024 |
| Shelbourne Avenue Real Estate Limited | Real estate | 2020 |
| Shelbourne Services Limited | Health & social care | 2018 |
| Shelby PVT Ltd | Hospitality | 2025 |
| Shelley Court Management Company (Bournemouth) Limited | Households | 1995 |
| Shelley Court Management Company (Ferndown) Limited | Real estate | 1975 |
| Shelley Heating Services Ltd | Construction | 2023 |
| Shelley Lodge Management Limited | Real estate | 2005 |
| Shelley Park Holdings Limited | Professional & scientific | 1998 |
| Shelly & Co Consultancy Limited | Professional & scientific | 2024 |
| Shepherd Montessori Schools Limited | Administrative & support | 2005 |
| Sheppard & Mccullough Edgehill Road Ltd | Real estate | 2020 |
| Sheppard Holdings Ltd | Real estate | 2015 |
| Sheraton Park (West Cliff) Freehold Limited | Households | 2012 |
| Sheraton Park (West Cliff) Management Limited | Households | 1998 |
| Sherborne Holdings Limited | Professional & scientific | 2007 |
| Sheridan Hope Associates Limited | Professional & scientific | 2003 |
| Sherluck Homes Limited | Construction | 2018 |
| Sherwood Freehold Limited | Professional & scientific | 2000 |
| Shiddatt 18 Limited | Real estate | 2021 |
| Shield Corporation Limited | Manufacturing | 2018 |
| Shield Sights Ltd | Manufacturing | 1986 |
| Shield Sports Limited | Manufacturing | 2020 |
| Shine & Bloom Ltd | Other services | 2026 |
| Shine (Dorset) Limited | Other services | 2020 |
| Shine Studios Limited | Administrative & support | 2021 |
| Shire Homes (Dorset) Limited | Construction | 2013 |
| Shiremead Consultants Limited | Professional & scientific | 2013 |
| Shiremead Surveyors Ltd | Professional & scientific | 2021 |
| Shires Copse Maintenance Limited | Households | 1990 |
| Shirley KA LAI Choi Ltd | Wholesale & retail | 2024 |
| Shirley Temple Limited | Hospitality | 2025 |
| Shiva Constructions Ltd | Construction | 2025 |
| Shivsoft Tech Ltd | Information & communication | 2024 |
| Shoaib Ahmad 1717 Ltd | Wholesale & retail | 2025 |
| Shoe BIZ (UK) Limited | Other services | 2007 |