| Shantipath Limited | Real estate | 2019 |
| Shanu Motors (UK) Limited | Wholesale & retail | 2025 |
| Sharia Homes Limited | Construction | 2018 |
| Sharon Vidan Ltd | Administrative & support | 2013 |
| Sharp Touch Limited | Other services | 2016 |
| Sharpe Stirling Recruitment Limited | Administrative & support | 2017 |
| Shattercone Ltd | Information & communication | 2017 |
| Shaukatss LLP | | 2021 |
| Shaun Leane Ltd | Administrative & support | 2005 |
| Shavaiz Limited | Health & social care | 2012 |
| Shaw Consultancy Services Limited | Professional & scientific | 2007 |
| Shaw Voice Limited | Arts & recreation | 2013 |
| Shayo Ltd | Real estate | 2020 |
| Shear Experience Limited | Wholesale & retail | 2006 |
| Shebana Consultancy Limited | Professional & scientific | 2004 |
| Shebana Enterprise Ltd | Administrative & support | 2024 |
| Shebana Investment Ltd | Professional & scientific | 2024 |
| Sheer Tech Ltd. | Professional & scientific | 2017 |
| Shelflane Ltd | Professional & scientific | 2023 |
| Shelley Capital (UK) Limited | Professional & scientific | 2018 |
| Shelley Capital Management LLP | | 2010 |
| Shelley Capital Management NO2 LLP | | 2026 |
| Shelley Capital NO 1 Limited | Professional & scientific | 2020 |
| Shelley Capital NO 10 Limited | Financial services | 2026 |
| Shelley Capital Reporting Limited | Professional & scientific | 2024 |
| Shelley Developments Limited | Construction | 2018 |
| Shelley Estates (Liverpool) Limited | Real estate | 2023 |
| Sheltering Arms Care Services Limited | Health & social care | 2021 |
| Shenkers LLP | | 2011 |
| Shenley Nails Beauty Ltd | Other services | 2025 |
| Shenley Road Properties Limited | Real estate | 2015 |
| Shenley UK Ltd | Wholesale & retail | 2007 |
| Shenoyorth Ltd | Health & social care | 2026 |
| Sherali Limited | Health & social care | 2019 |
| Sheraton Investments Limited | Real estate | 2024 |
| Sheraton Textiles Limited | Wholesale & retail | 1991 |
| Sheridan Heights Limited | Real estate | 2023 |
| Sheringham Services Limited | Households | 1990 |
| Shernagati Limited | Health & social care | 2023 |
| Sherr Technologies Limited | Information & communication | 2004 |
| Sherwalsh Property Ltd | Real estate | 2025 |
| Sherwood and Company Limited | Professional & scientific | 2008 |
| Sherwood Consulting Services Ltd | Information & communication | 2022 |
| Shian FOO Ltd | Health & social care | 2012 |
| Shield Double Glazing Limited | Manufacturing | 2007 |
| Shieldplay Limited | Administrative & support | 2012 |
| Shifting Culture Ltd | Information & communication | 2018 |
| Shining Stars Day Nursery Limited | Administrative & support | 2012 |
| Shinso Skin Care Limited | Manufacturing | 2011 |
| Ship Inn Cornwall Limited | Hospitality | 2002 |
| Shipud Limited | Hospitality | 2020 |
| Shir Limited | Financial services | 2026 |
| Shirley's (GN) Luton Ltd | Hospitality | 2022 |
| Shiva Hotels Heathrow Limited | Hospitality | 2010 |
| Shiva Hotels Limited | Hospitality | 2002 |
| Shiva Hotels Morley Limited | Hospitality | 2014 |
| Shiva Marlborough Ltd | Hospitality | 2018 |
| Shiva Marylebone Lane Ltd | Hospitality | 2022 |
| Shmoomoo Limited | Professional & scientific | 2023 |
| Shoecase Properties Ltd | Real estate | 2021 |
| Shoffyj Designs Limited | Information & communication | 2015 |
| Shogeki TV Ltd | Information & communication | 2025 |
| Shoolin IT Ltd | Information & communication | 2017 |
| Shootershill Properties Ltd | Construction | 2022 |
| Shopper Gold Ltd | Wholesale & retail | 2012 |
| Shopy GS Limited | Construction | 2017 |
| Shoreprop Limited | Real estate | 2022 |
| Shorplans Architectural Services Ltd | Professional & scientific | 2014 |
| SHQ Eton Ltd | Health & social care | 2020 |
| Shreejee Motors (London) Limited | Wholesale & retail | 2012 |
| Shri Vithal Foods PVT Ltd | Hospitality | 2025 |
| Shteam Snacks Ltd | Wholesale & retail | 2025 |
| SHU SHU Properties Limited | Real estate | 2024 |
| Shumuly Ltd | Professional & scientific | 2020 |
| Shuny Health Ltd | Health & social care | 2014 |
| Shutter Sound Ltd | Information & communication | 2011 |
| Siam Holdings Limited | Real estate | 2026 |
| Siam Thara Limited | Other services | 2019 |
| Sichere Building Services Limited | Construction | 2001 |
| SID & Co Investments Ltd | Real estate | 2025 |
| Sidestep Rugby Ltd | Education | 2015 |
| Sidlav Limited | Administrative & support | 2018 |
| Sidney John Standig Ltd | Real estate | 2008 |
| Sidney John Standig NO 1 Ltd | Real estate | 2012 |
| Sidney Rigging Ltd | Professional & scientific | 2026 |
| Sienna Diamonds Ltd | Wholesale & retail | 2026 |
| Sienna Prop Co Limited | Real estate | 2025 |
| Siep Global Consulting Ltd | Financial services | 2014 |
| Sigma Contractors Ltd | Construction | 2012 |
| Signature Branding Limited | Administrative & support | 2018 |
| Signature CNC Limited | Administrative & support | 2009 |
| Signum Protection Group Ltd | Administrative & support | 2021 |
| Sihaaf Ltd | Health & social care | 2024 |
| Siit Solutions Limited | Information & communication | 2011 |
| Silent Treatment Soundproofing Ltd | Construction | 2015 |
| Silicon Design Ltd | Information & communication | 2012 |
| Silver Bullet Audio Limited | Arts & recreation | 2011 |
| Silver FOX Collectibles Ltd | Manufacturing | 2017 |
| Silver Leaf Lighting Limited | Administrative & support | 2011 |
| Silver Linings Estates Ltd | Real estate | 2018 |