| Salt of the Earth Productions Ltd | Arts & recreation | 2024 |
| Saltburn Court (Bushey) Limited | Real estate | 1963 |
| Salty Woods Ltd | Wholesale & retail | 2025 |
| Salubrious Ltd | Information & communication | 2000 |
| Salut London Limited | Arts & recreation | 2014 |
| SAM Carlo U.K Ltd | Wholesale & retail | 2020 |
| SAM Import Ltd | Wholesale & retail | 2023 |
| SAM J Rothery Ltd | Construction | 2020 |
| Samaaya Homes Limited | Real estate | 2023 |
| Samantha Levin Ltd | Health & social care | 2012 |
| Samara Medical Limited | Health & social care | 2013 |
| Samblonto Transport Ltd | Other services | 2018 |
| Samco Consultancy Limited | Professional & scientific | 2021 |
| Samconsultancie Limited | Professional & scientific | 2019 |
| Samen Investment Ltd | Administrative & support | 2017 |
| Samfix London Ltd | Construction | 2022 |
| Samquality Ltd | Wholesale & retail | 2025 |
| Sams Sports Consultancy Limited | Professional & scientific | 2024 |
| Samuel & Co Trading Limited | Information & communication | 2012 |
| Samuel Trans Ltd | Transport & logistics | 2022 |
| Samvi Limited | Information & communication | 2009 |
| Samyar Development Limited | Real estate | 2023 |
| SAN Carlo UK Limited | Wholesale & retail | 1995 |
| Sanchard Investments Ltd | Real estate | 2022 |
| Sanctuary Banbury Limited | Health & social care | 2016 |
| Sandleas Limited | Real estate | 2021 |
| Sandnsaint Ltd | Wholesale & retail | 2025 |
| Sandro Kovacs Ltd | Transport & logistics | 2017 |
| Sandy Lane Consultancy Limited | Wholesale & retail | 2024 |
| Sanghani Property Partnership Limited | Real estate | 2022 |
| Sanitie Limited | Health & social care | 2019 |
| Sanjay Chibba Limited | Administrative & support | 2011 |
| Sanjo Construction Limited | Construction | 2024 |
| Santash Properties Limited | Real estate | 2023 |
| Saplewood Trading Ltd | Wholesale & retail | 2025 |
| Sarah-Jane LAM Ltd | Health & social care | 2018 |
| SARAH20 Ltd | Transport & logistics | 2019 |
| Sararun Ltd | Professional & scientific | 2024 |
| Sargeant Partnership Group Limited | Professional & scientific | 2024 |
| Sargeant Partnership Limited | Professional & scientific | 2024 |
| Sarla House Ltd | Real estate | 2023 |
| Saro Properties Ltd | Real estate | 2014 |
| Sarpong Enterprises Company Limited | Transport & logistics | 2017 |
| Sars Collectibles Ltd | Wholesale & retail | 2018 |
| Sarva Properties Limited | Real estate | 2021 |
| Sarvm Ltd | Health & social care | 2020 |
| SAS Agri Limited | Manufacturing | 2011 |
| Sassy Create Limited | Information & communication | 2023 |
| Sassy Films Limited | Information & communication | 2006 |
| Satara Developments Limited | Administrative & support | 2020 |
| Satara Group Limited | Administrative & support | 2020 |
| Satara Investments Limited | Administrative & support | 2020 |
| Satara Projects Limited | Administrative & support | 2020 |
| Satco Ltd | Extraterritorial | 2023 |
| Sathe Limited | Health & social care | 2017 |
| Sathyabama Property Ltd | Real estate | 2019 |
| Satima Ltd | Wholesale & retail | 2017 |
| Sauce Catering Ltd | Hospitality | 2022 |
| Saultcombe Equity Partners Limited | Professional & scientific | 2022 |
| Saultcombe Limited | Professional & scientific | 2022 |
| Savannah Finance Partners Limited | Professional & scientific | 2025 |
| Save Minds Limited | Health & social care | 2020 |
| Savill Building Solutions Ltd | Construction | 2018 |
| Savvy Navvy Ltd | Professional & scientific | 2017 |
| Sawdog Limited | Information & communication | 2008 |
| Saxena Realty Ltd | Real estate | 2021 |
| Saya Food and Wine Ltd | Wholesale & retail | 2010 |
| Sayan Strategies Ltd | Professional & scientific | 2023 |
| Sayed Traders Limited | Hospitality | 2025 |
| SB 125 Ltd | Professional & scientific | 2015 |
| SB Films Ltd | Information & communication | 2026 |
| SBB Consultants Limited | Administrative & support | 2016 |
| Sbck Health Ltd | Health & social care | 2021 |
| SBL Properties Ltd | Real estate | 2019 |
| SBS David Limited | Wholesale & retail | 2012 |
| SC Consultancy Limited | Professional & scientific | 2024 |
| SC FAS 1 Holdco Limited | Real estate | 2021 |
| SC FAS 2 Holdco Limited | Real estate | 2024 |
| SC FCP Limited | Financial services | 2024 |
| SC Manco Limited | Financial services | 2025 |
| SC Mipco Limited | Financial services | 2025 |
| Scaffolding Services( UK ) Ltd | Construction | 2014 |
| Scale UP Financial Limited | Professional & scientific | 2023 |
| Scan Sleuth Limited | Health & social care | 2025 |
| Scarlat Services Limited | Construction | 2017 |
| SCB Corporate Ltd | Professional & scientific | 2025 |
| SCB Props Limited | Other services | 2014 |
| Scene Double Limited | Manufacturing | 1992 |
| Scentiment Gifts Limited | Other services | 2019 |
| Schaller Clinic Ltd | Health & social care | 2023 |
| Schechter Entertainment Ltd | Arts & recreation | 2026 |
| Scher & Marks Limited | Wholesale & retail | 2013 |
| Schlossberg UK Limited | Administrative & support | 2018 |
| School Badge Limited | Manufacturing | 2013 |
| School Enterprises Limited | Real estate | 2019 |
| Schoony Limited | Arts & recreation | 2020 |
| Schoub Medical Ltd | Health & social care | 2022 |
| Scialo Consulting Ltd | Information & communication | 2025 |
| SCM Enterprises Ltd | Professional & scientific | 2012 |
| Scott and Babs Woodfired Food Limited | Hospitality | 2015 |