| EM Mouldings Ltd | Arts & recreation | 2021 |
| Emandar Management Limited | Extraterritorial | 2011 |
| Emandar Nominees Limited | Professional & scientific | 2003 |
| Emandar Tax Ltd | Professional & scientific | 2016 |
| Emarel Services Limited | Professional & scientific | 1975 |
| Embrace Property Services Ltd | Public administration | 2025 |
| EME Wines Limited | Hospitality | 2018 |
| Emerald Apartments RTM Company Limited | Households | 2019 |
| Emerald Lets Ltd | Real estate | 2019 |
| Emerging Limited | Other services | 2007 |
| Emeryrock Limited | Information & communication | 2019 |
| EMI General Construction UK Ltd | Construction | 2022 |
| Emil Radu Ltd | Transport & logistics | 2017 |
| Eminenttea Ltd | Wholesale & retail | 2024 |
| Emma Peach Ltd | Information & communication | 2006 |
| Emmanuel Limited | Health & social care | 2008 |
| Emmaya Property LLP | | 2026 |
| Emmett Therapies UK Ltd | Education | 2011 |
| Emmlaumax Limited | Administrative & support | 2012 |
| Emmy Media Productions Ltd | Information & communication | 2026 |
| EMO1986 Ltd | Construction | 2016 |
| Emotional Alchemist Limited | Health & social care | 2023 |
| EMP Cars Limited | Transport & logistics | 2025 |
| Empire of Builders Ltd | Construction | 2022 |
| Empire of Glass Ltd | Construction | 2018 |
| Empower Healthcare Group Limited | Financial services | 2026 |
| Empower Investments Limited | Real estate | 2020 |
| Empower Youth Ventures CIC | Administrative & support | 2024 |
| Emra Limited | Households | 1996 |
| Emusik Ltd | Information & communication | 2011 |
| Enamel Dental Limited | Health & social care | 2021 |
| Enchanted Cottage Astrology Limited | Information & communication | 2022 |
| Endeavour Automotive Ltd | Wholesale & retail | 2012 |
| Endocrine Medicine Limited | Health & social care | 2019 |
| Endodiabetes Ltd | Information & communication | 2012 |
| ENDOV8 Clinical Limited | Health & social care | 2024 |
| ENDOV8 Group Limited | Financial services | 2024 |
| Endswell Consulting Limited | Information & communication | 2026 |
| Endurance Limits Limited | Arts & recreation | 2026 |
| Energise Consultancy Limited | Professional & scientific | 2011 |
| Energy Land & Waste Limited | Energy | 2018 |
| Enfield GP Federation - Training Hub Limited | Education | 2023 |
| Enfield Healthcare Cooperative Ltd | Health & social care | 2017 |
| Engine Exports (UK) Ltd | Wholesale & retail | 2013 |
| Engineering Services Incorporated Ltd | Professional & scientific | 2019 |
| English County Hotels,Limited | Real estate | 1931 |
| Engracia Limited | Administrative & support | 2024 |
| Enjoy the Pizza Limited | Hospitality | 2018 |
| Enlatados Online Ltd | Professional & scientific | 2025 |
| Ennerdale Properties Limited | Real estate | 1998 |
| ENR Services Limited | Professional & scientific | 2024 |
| Enriching Media Limited | Information & communication | 2012 |
| Enright Electrical Contractors Ltd | Construction | 2020 |
| Enright Property Group Limited | Real estate | 2018 |
| ENT at 150 Limited | Health & social care | 2013 |
| Entel Communications Holdings Limited | Professional & scientific | 2010 |
| Entel UK Limited | Manufacturing | 1996 |
| Enterprise AG Ltd | Construction | 2020 |
| Enterprise Building System Ltd | Construction | 2025 |
| Entire Transformation Limited | Professional & scientific | 2021 |
| Environmental Tracing Ltd | Professional & scientific | 2021 |
| EO Holdco Ltd | Administrative & support | 2024 |
| Eopp Ltd | Information & communication | 2017 |
| EP770 Ltd | Other services | 2025 |
| Ephthebarber Limited | Other services | 2017 |
| Epic Crust Ltd | Hospitality | 2020 |
| Epicdermis Medical Ltd | Health & social care | 2016 |
| Epicsass Limited | Financial services | 2026 |
| Epifan Ltd | Information & communication | 2017 |
| Epoq Group Ltd | Professional & scientific | 2001 |
| Epoq IT Holdings Limited | Financial services | 2020 |
| Epoq Legal Ltd | Professional & scientific | 1999 |
| Epoq Ventures Limited | Financial services | 2023 |
| Epoq-It Limited | Information & communication | 2002 |
| Equinox Realty Limited | Real estate | 2022 |
| Equisure UK Limited | Financial services | 2025 |
| Equity Dynamics PR Limited | Professional & scientific | 2014 |
| Erad Partners UK Limited | Real estate | 2024 |
| Eraikin Ltd | Real estate | 2022 |
| Eren Developments Ltd | Construction | 2017 |
| ERG Industrial Holdings (UK) Ltd | Financial services | 2026 |
| Ergoline Limited | Transport & logistics | 2023 |
| Erik Home Construction Limited | Construction | 2020 |
| Erik Inarra Osteopathy Ltd | Health & social care | 2020 |
| Erock Power Investments Limited | Real estate | 2024 |
| Erock Power Limited | Financial services | 2024 |
| ERS Chauffeurs Limited | Transport & logistics | 2022 |
| Ersd Limited | Financial services | 2021 |
| ES Construction Solutions Ltd | Construction | 2022 |
| ES Medical Ltd | Health & social care | 2022 |
| Esao Group UK Ltd | Education | 2022 |
| Escada (UK) Limited | Wholesale & retail | 2009 |
| Escott Landscape Development Ltd | Construction | 2021 |
| Eskay Records Limited | Administrative & support | 2006 |
| Esmara Transport LLP | | 2016 |
| Esmart Systems UK Ltd | Information & communication | 2016 |
| Essence of Nature Ltd | Other services | 2012 |
| Essentially Group Limited | Administrative & support | 2022 |
| Essex Contractor Services Ltd | Administrative & support | 2020 |
| Essex Locks & Glazing Ltd | Construction | 2018 |