| Richmond Bright Limited | Professional & scientific | 2020 |
| Ride a Wave Clothing Limited | Wholesale & retail | 2020 |
| Rifty Ltd | Manufacturing | 2025 |
| Rimrose Road Valeting(Bootle) Ltd | Administrative & support | 2020 |
| Ringtail Comms Limited | Information & communication | 2017 |
| Risa Brickwork Ltd | Construction | 2026 |
| Rishton Abrasive Products Limited | Wholesale & retail | 2001 |
| Ritual Spirit Ltd | Manufacturing | 2023 |
| Rivergate Estates Limited | Households | 2025 |
| Riverside Group (North West) Ltd | Wholesale & retail | 2012 |
| Riverside Lending Ltd | Financial services | 2012 |
| Riverside Racing Ltd | Wholesale & retail | 2012 |
| RJC Brickwork and Building Ltd | Construction | 2026 |
| Rjwrail Ltd | Construction | 2016 |
| Rkrr Limited | Hospitality | 2026 |
| RLK Investments Ltd | Real estate | 2024 |
| RLM Property Acquisitions Limited | Real estate | 2024 |
| RLS Marine Limited | Mining & quarrying | 2015 |
| RMS Finance Limited | Other services | 2014 |
| Roadtrippers Events Limited | Arts & recreation | 2019 |
| Robert Solutions Ltd | Transport & logistics | 2026 |
| Robin Carl Hector Limited | Extraterritorial | 2024 |
| Roche Developments Limited | Real estate | 2006 |
| Role Creative Limited | Professional & scientific | 2014 |
| Rolo Property Ltd | Real estate | 2025 |
| Roman Kingdom Limited | Arts & recreation | 2018 |
| RON Sullivans Limited | Real estate | 2019 |
| Ronal Events & Hospitality Limited | Hospitality | 2014 |
| Rose & Albert Childrenswear Limited | Wholesale & retail | 2019 |
| Rose Quartz Care & Support Services Limited | Health & social care | 2026 |
| Rosie's Deliveries Ltd | Transport & logistics | 2025 |
| Rotary Drives & Controls Ltd | Manufacturing | 2018 |
| Route 66 Limited | Other services | 2006 |
| ROY Henry & Co. Limited | Manufacturing | 1981 |
| RPT Trading Ltd | Wholesale & retail | 2025 |
| RS Contractors (NW) Ltd | Construction | 2025 |
| RS Marine Limited | Transport & logistics | 2017 |
| RSM Air Conditioning & Refrigeration Ltd | Manufacturing | 2008 |
| RTL Property Consultants Ltd | Professional & scientific | 2025 |
| Ruby Engineering Limited | Professional & scientific | 2016 |
| Ruby PVT Ltd | Wholesale & retail | 2026 |
| Rurcsmartmobiles Ltd | Wholesale & retail | 2019 |
| Rushserve Limited | Wholesale & retail | 1988 |
| Ryders Winch & Recovery Ltd | Manufacturing | 2023 |
| S & TK Properties Limited | Real estate | 2026 |
| S B Grab & Tipper Hire Ltd | Construction | 2024 |
| S J F Construction Ltd | Construction | 2017 |
| S K S Bar and Grill Limited | Hospitality | 2024 |
| S Line Autos North West Limited | Wholesale & retail | 2017 |
| S Tivenan Ltd | Manufacturing | 2013 |
| S.S Chauffeur Services Ltd | Transport & logistics | 2018 |
| Safe Community Homes CLT C.I.C. | Real estate | 2020 |
| Safe Regeneration Ltd | Arts & recreation | 2000 |
| Safebuy-Uk Ltd | Information & communication | 2019 |
| Safety Steps Consultants Ltd | Education | 2024 |
| Saho's Barbers Ltd | Other services | 2021 |
| SAJ Joinery Ltd | Construction | 2025 |
| Sakaeo Scaffolding Solutions Ltd | Construction | 2025 |
| Saleem Consultancy Solutions Ltd | Professional & scientific | 2023 |
| Saleem Limited | Professional & scientific | 1996 |
| Salisbury Limited 129 Ltd | Hospitality | 2025 |
| Samuel Skelly Limited | Manufacturing | 1952 |
| SAN SAN Bubble Tea Ltd | Hospitality | 2022 |
| Sana Mini Market Knowsley Road Ltd | Wholesale & retail | 2025 |
| SANCAK12 Ltd | Wholesale & retail | 2019 |
| Sanco & Sons Properties Ltd | Real estate | 2026 |
| Sandfield Property Group Ltd | Real estate | 2026 |
| Sandra Evans Health Policy Ltd | Professional & scientific | 2020 |
| Sandstone Property & Estates Limited | Real estate | 2026 |
| Sandway Homes Limited | Construction | 2018 |
| Sangeetha Ltd | Wholesale & retail | 2025 |
| Sanzabull Surveying Ltd | Construction | 2025 |
| Satplan Ltd | Professional & scientific | 2012 |
| Satplan Strategic Land Ltd | Professional & scientific | 2021 |
| Satterthwaite Brooks & Pomfret LLP | | 2007 |
| Scaffolding Technical Ltd | Construction | 2025 |
| Scafftrain Limited | Professional & scientific | 2025 |
| School for Startups Limited | Administrative & support | 2008 |
| Science Toll Ltd | Agriculture & fishing | 2025 |
| Scott Street 1972 Limited | Extraterritorial | 2014 |
| Scouse Ghetto Gourmet Ltd | Professional & scientific | 2026 |
| Scream Machine Ltd | Professional & scientific | 2002 |
| SCRIPZ1 Ltd | Information & communication | 2025 |
| Scrubs HQ Ltd | Wholesale & retail | 2023 |
| Seaforth Autoparts Limited | Wholesale & retail | 2014 |
| Seaforth Marine & Offshore Limited | Manufacturing | 2011 |
| Seaforth Refrigeration Limited | Wholesale & retail | 2008 |
| Sean Sharp Consultancy Ltd | Professional & scientific | 2026 |
| Sean Sharp Liverpool Property Ltd | Real estate | 2026 |
| Sean's Place CIC | Public administration | 2020 |
| SEB AG Property Ltd | Real estate | 2025 |
| Securing Boundaries CIC | Manufacturing | 2024 |
| Sefton (ACS) Holding Company Limited | Financial services | 2018 |
| Sefton Beer Company Limited | Wholesale & retail | 2016 |
| Sefton Cafe Connect CIC | Education | 2025 |
| Sefton Civils Ltd | Real estate | 2021 |
| Sefton Community Pantry CIC | Hospitality | 2020 |
| Sefton Group (North West) Holdings Limited | Financial services | 2022 |
| Sefton Haulage Limited | Transport & logistics | 2022 |
| Sefton New Directions Limited | Health & social care | 2007 |