| Emprove Limited | Professional & scientific | 2018 |
| EMS Property Ltd | Real estate | 2017 |
| Emsoft Consulting Ltd | Information & communication | 2021 |
| Emth Ltd | Transport & logistics | 2025 |
| Emullasoft Ltd | Information & communication | 2014 |
| Enable Therapy Services Limited | Health & social care | 2008 |
| Enabling Homes Holdings Ltd. | Real estate | 2017 |
| Enabling ME Ltd | Professional & scientific | 2017 |
| Enamel Services Limited | Health & social care | 2022 |
| Enayat Iqbal Limited | Health & social care | 2009 |
| Enayat Phone & Vapes Limited | Wholesale & retail | 2026 |
| ENB Property Ltd | Real estate | 2026 |
| Encare Healthcare Ltd | Health & social care | 2015 |
| Encompass Education Support Limited | Education | 2019 |
| Encompass Projects Ltd | Construction | 2020 |
| Encore Dance Studio Limited | Education | 2025 |
| Endacott Enterprises Limited | Administrative & support | 2011 |
| Endgame Software Limited | Information & communication | 2017 |
| Endura Haulage Ltd | Transport & logistics | 2024 |
| Endurance Services Limited | Administrative & support | 2016 |
| Enduro Digital Marketing Limited | Information & communication | 2016 |
| Endynamics Ltd | Wholesale & retail | 2011 |
| Eneadri Ltd | Wholesale & retail | 2023 |
| Enegex Ltd | Construction | 2025 |
| Energy Connections Project Management Limited | Professional & scientific | 2020 |
| Energy Consulting London Ltd | Information & communication | 2021 |
| Energy Hub Solutions Ltd | Administrative & support | 2025 |
| Energy Innovation Deployment Partners Limited | Professional & scientific | 2025 |
| Energy Navigators Limited | Professional & scientific | 2025 |
| Energy Search Ltd | Energy | 2014 |
| Energy Services Direct Limited | Wholesale & retail | 2024 |
| Energy Shield Windows & Doors Ltd | Construction | 2025 |
| Energy Surveyors (Northwest) Ltd | Professional & scientific | 2008 |
| Energyss Limited | Construction | 2025 |
| ENF Engraving Ltd | Wholesale & retail | 2022 |
| ENG Homes Ltd | Construction | 2025 |
| Engage & Explore Ltd | Administrative & support | 2025 |
| Engen Group Limited | Manufacturing | 2010 |
| Engin Services Ltd | Professional & scientific | 2024 |
| Engine Force Limited | Wholesale & retail | 2024 |
| Engine Tech Centre Ltd | Other services | 2026 |
| Engineering Design and Logistics Limited | Professional & scientific | 2001 |
| Engineering LAB Ltd | Information & communication | 2017 |
| Engineering Metal Services Limited | Manufacturing | 1986 |
| Engineering Systems Design (Group) Limited | Professional & scientific | 2022 |
| Engines 2 YOU Ltd | Wholesale & retail | 2024 |
| Engledene Properties Limited | Real estate | 2018 |
| Engtek Limited | Professional & scientific | 2020 |
| ENH Lettings Ltd | Real estate | 2021 |
| Enhanced AI Costs Limited | Professional & scientific | 2026 |
| Enhanced Childrens Services Limited | Education | 2013 |
| Enhanced Foster Care Limited | Health & social care | 2007 |
| Enhanced Learning Services Limited | Education | 2017 |
| Enhanced Parent and Child Services Ltd | Extraterritorial | 2013 |
| Enipla Ltd | Financial services | 2022 |
| Enlightened Properties UK Ltd | Real estate | 2025 |
| Enlightened Transformation for Mind Body and Soul Ltd | Health & social care | 2022 |
| Enliva Care Group Ltd | Financial services | 2020 |
| Ennan Investments Ltd | Administrative & support | 2016 |
| Ennuvo Limited | Professional & scientific | 2023 |
| Ennytrims Hair & Gold Ltd | Other services | 2021 |
| Enoch Taxi Ltd | Transport & logistics | 2025 |
| Enoteca (Manchester) Limited Ltd | Hospitality | 2025 |
| Enoteca (Wholesale) Ltd | Wholesale & retail | 2025 |
| Ensco 1367 Limited | Financial services | 2020 |
| Ensco 2020 Limited | Real estate | 2020 |
| Ensign Films Ltd | Information & communication | 2023 |
| Ensol Limited | Manufacturing | 1992 |
| Entek Door Systems Limited | Construction | 2013 |
| Entelligent Value Enhancement Ltd | Professional & scientific | 2014 |
| Enterprise FP Ltd | Professional & scientific | 2024 |
| Enterprise Systems Computing Limited | Information & communication | 1997 |
| Entertainment Magpie Group Limited | Professional & scientific | 2015 |
| Entertainment Magpie Holdings Limited | Administrative & support | 2011 |
| Entertainment Magpie Limited | Wholesale & retail | 2007 |
| Entire Holdings Limited | Financial services | 2020 |
| Entire Projects Limited | Construction | 2009 |
| Entrepreneurial Spirit Limited | Manufacturing | 2020 |
| Entrytec Locksmiths Ltd | Other services | 2017 |
| Entwisle Joinery Ltd | Construction | 2023 |
| Entwistle and Sons Limited | Construction | 2021 |
| Entwistle Inns Ltd | Hospitality | 2024 |
| Entwistle Lettings Limited | Real estate | 2025 |
| Enviro Build & Maintenance Ltd | Construction | 2024 |
| Enviro Flood Systems Limited | Wholesale & retail | 2016 |
| Enviro Heating & Plumbing Services Ltd | Construction | 2002 |
| Envirobund UK Ltd | Administrative & support | 2005 |
| Envirocool Hvac Services Ltd | Construction | 2016 |
| Envirolizer Limited | Wholesale & retail | 2018 |
| Environmental HLT Limited | Health & social care | 2023 |
| Environmental Leadership Ltd | Professional & scientific | 2002 |
| Environmental Roofing Services Ltd | Construction | 2014 |
| Environmental Services Bolton Ltd | Water & waste | 2012 |
| Envirosafe Cleaning Ltd | Water & waste | 2025 |
| Envirosus Solutions Ltd | Professional & scientific | 2022 |
| Envirotek N.W. Limited | Water & waste | 2013 |
| Envirowasteuk Limited | Water & waste | 2026 |
| Envirowattle Ltd | Extraterritorial | 2011 |
| Envision Solicitors Limited | Professional & scientific | 2020 |
| Enyx.Digital Ltd | Manufacturing | 2024 |