| Derby Food & Beverages Limited | Hospitality | 2016 |
| Derby Mill Beds & Furniture Ltd | Wholesale & retail | 2025 |
| Derby Mill Interiors Limited | Wholesale & retail | 2018 |
| Derby ST Dentist Ltd | Health & social care | 2010 |
| Derby ST Shakes Ltd | Other services | 2025 |
| Derbyshire Building Design Ltd | Professional & scientific | 2023 |
| Derbyshire Real Estate Ltd | Real estate | 2026 |
| Derdale Developments Limited | Construction | 2014 |
| Dereve Renewable Energy Limited | Construction | 2013 |
| Deriax Ltd | Wholesale & retail | 2018 |
| Deriax Realty Ltd | Real estate | 2021 |
| Derins Driving Services Limited | Transport & logistics | 2023 |
| Derma Direct UK Limited | Wholesale & retail | 2024 |
| Dermaesthetics L.A.B Ltd | Health & social care | 2021 |
| Dermagen Ltd | Other services | 2026 |
| Dermal HQ UK Ltd | Manufacturing | 2026 |
| Dermas Roller Ltd | Wholesale & retail | 2024 |
| Dermaskinuk Ltd | Other services | 2024 |
| Dermatherapy School of Beauty Ltd | Other services | 2021 |
| Dermavere Aesthetics Limited | Other services | 2022 |
| Dermis Cosmetic Limited | Wholesale & retail | 2025 |
| Dervan Limited | Professional & scientific | 2008 |
| Derwent Homes Ltd | Real estate | 2019 |
| Desarchi Contracts Ltd | Administrative & support | 2026 |
| Desi Cleaners Ltd | Administrative & support | 2024 |
| Desi Fusion Limited | Hospitality | 2018 |
| Desi House Limited | Hospitality | 2019 |
| Design 10 Limited | Professional & scientific | 2016 |
| Design and Build Publishing Ltd | Information & communication | 2012 |
| Design and Craft Joinery Limited | Construction | 2025 |
| Design and More Ltd | Construction | 2023 |
| Design and Print Warehouse Ltd | Manufacturing | 2017 |
| Design Fiesta Limited | Wholesale & retail | 2023 |
| Design Hub Solutions Ltd | Information & communication | 2022 |
| Design Solution Projects Ltd | Professional & scientific | 2019 |
| Design Surveying Partnership Ltd | Professional & scientific | 2009 |
| Design TWENTY2 Studio Ltd | Manufacturing | 2025 |
| Designer Stitches Limited | Manufacturing | 2020 |
| Designer Walls & More Ltd | Wholesale & retail | 1994 |
| Designidge Ltd | Professional & scientific | 2019 |
| Desire Cars Ltd | Wholesale & retail | 2019 |
| Desk Aura Ltd | Wholesale & retail | 2025 |
| Desk Work Solutions Limited | Administrative & support | 2024 |
| Dessert Magic Box Limited | Wholesale & retail | 2021 |
| Destiny Floors Limited | Construction | 2026 |
| Detas Consulting Limited | Administrative & support | 2023 |
| Detection Security Systems Ltd | Administrative & support | 2016 |
| Dev's Grocers Limited | Wholesale & retail | 2012 |
| Devere Connect Limited | Administrative & support | 2023 |
| Devica Limited | Information & communication | 2025 |
| Deviceqr Limited | Professional & scientific | 2026 |
| Devine Commercial Consulting Ltd | Professional & scientific | 2020 |
| Devito Travel Ltd | Other services | 2024 |
| Devji Limited | Financial services | 2005 |
| Devon Rape Crisis and Sexual Abuse Services Ltd | Information & communication | 2011 |
| Devonshire Court Management Limited | Real estate | 2002 |
| Devonshire Park (Bolton) Management Company Limited | Households | 2014 |
| Devotion Pet Cremation Services Ltd | Other services | 2024 |
| Devpulse Limited | Information & communication | 2018 |
| Dewey Residentials Ltd | Real estate | 2015 |
| Dexter & Waddle Ltd | Wholesale & retail | 2009 |
| Dexter Chicken & Grill Ltd | Hospitality | 2025 |
| Dexter's Chicken Pizza and Grill Ltd | Hospitality | 2020 |
| Dexters Bolton Ltd | Hospitality | 2024 |
| Dexters Chicken and Pizza Wiganltd Ltd | Hospitality | 2025 |
| Dezcom UK Ltd | Wholesale & retail | 2021 |
| Dezilk Limited | Hospitality | 2025 |
| Dezille Ltd | Other services | 2025 |
| DF Recovery Services Limited | Transport & logistics | 2023 |
| DFH Mechanical Process Ltd | Manufacturing | 2015 |
| DFW Construction Ltd | Construction | 2021 |
| DFX the 1% Ltd | Information & communication | 2024 |
| DG Glazing and Construction Ltd | Construction | 2025 |
| DG Heating Services Ltd | Construction | 2020 |
| DG Kitchen Installations Limited | Construction | 2014 |
| DGC Electrical Services Ltd | Construction | 2019 |
| DGD Garage Doors Ltd | Construction | 2022 |
| Dgdental Limited | Health & social care | 2024 |
| Dggolf Ltd | Arts & recreation | 2024 |
| Dgjjensen Ltd | Transport & logistics | 2023 |
| DGM Recovery Services Limited | Transport & logistics | 2025 |
| Dgmi Limited | Professional & scientific | 2011 |
| DH Construction Northwest Ltd | Construction | 2023 |
| DH Heat-Care Limited | Construction | 2019 |
| DH Solutions Ltd | Wholesale & retail | 2025 |
| DHA Solutions Ltd | Transport & logistics | 2026 |
| Dharmea Financial Planning Ltd | Financial services | 2018 |
| Dhatri Enterprise Limited | Health & social care | 2014 |
| Dhaygude Services Ltd | Professional & scientific | 2025 |
| Dhaz Technologies Limited | Wholesale & retail | 2025 |
| DHI Environmental Limited | Construction | 2008 |
| DHK Logistics Limited | Transport & logistics | 2021 |
| DHP Property Management Ltd | Real estate | 2021 |
| DHT Holdings Limited | Financial services | 2026 |
| DI Ferro NW Ltd | Manufacturing | 2024 |
| Diagnostika Limited | Professional & scientific | 2016 |
| Dial M for Moulsdale Limited | Professional & scientific | 2026 |
| Dialog Buzz Ltd | Information & communication | 2024 |
| Diamond ABZ Limited | Health & social care | 2023 |
| Diamond ALE Ltd | Hospitality | 2025 |