| Noblees Consults Ltd | Health & social care | 2024 |
| Noblees Investments Ltd | Financial services | 2023 |
| Noblees Ltd | Health & social care | 2014 |
| Noblegen Cryogenics Ltd | Manufacturing | 1991 |
| North East Commissioning Solutions Ltd | Other services | 2025 |
| North East Fleet Support Limited | Wholesale & retail | 2019 |
| North Fortune 88 Limited | Hospitality | 2024 |
| Northern Switchgear & Controls Limited | Manufacturing | 1994 |
| Northumbrian Electrical Limited | Construction | 2018 |
| Nuby UK LLP | | 2009 |
| Oncologia Ltd | Professional & scientific | 2021 |
| Opus MP Limited | Construction | 2023 |
| Orrsome Enterprises Limited | Extraterritorial | 2020 |
| Oslo Enterprises Limited | Information & communication | 2015 |
| PAB Consultancy Limited | Professional & scientific | 2016 |
| Paula Stubbs Limited | Health & social care | 2007 |
| Pearl Clinical Healthcare Ltd | Health & social care | 2026 |
| Pest Shield North East Ltd | Administrative & support | 2024 |
| Pilote Classics Limited | Wholesale & retail | 2019 |
| PJK Management Ltd | Construction | 2019 |
| Plato Capital Ltd | Real estate | 2018 |
| Polyurea Waterproofing Solutions Limited | Construction | 2017 |
| Project Business Solutions Ltd | Other services | 2011 |
| Q&C (NE) Ltd | Hospitality | 2025 |
| Quantum Accountancy Services Limited | Professional & scientific | 2006 |
| R&Co Marine Services Limited | Professional & scientific | 2020 |
| Rachel Howe Limited | Other services | 2023 |
| Rakelane Consults Ltd | Health & social care | 2025 |
| Ranya and Partner Ltd | Administrative & support | 2024 |
| Raxpro Ltd | Manufacturing | 2018 |
| Rccac Limited | Real estate | 2025 |
| RD Slinger Services Ltd | Professional & scientific | 2015 |
| Rehd Limited | Professional & scientific | 2024 |
| Reinkops Investment Ltd | Real estate | 2026 |
| RG Woodwind Ltd | Wholesale & retail | 2024 |
| Ripon Medical Services Limited | Real estate | 2022 |
| Ristorante Fratelli Limited | Hospitality | 2006 |
| Ruffman Consulting Limited | Professional & scientific | 2017 |
| Ruspencia Group Limited | Financial services | 2024 |
| Ruspencia Holdings Limited | Health & social care | 2021 |
| Ruspencia SPV 1 Limited | Real estate | 2026 |
| S.E.L.F. (North East) Limited | Health & social care | 1995 |
| Sabatini Limited | Hospitality | 2003 |
| Samuel George Tree Services Limited | Administrative & support | 2022 |
| SAN Legal Limited | Professional & scientific | 2020 |
| SAN85 Property Ltd | Real estate | 2023 |
| Sapphire Engineering (North East) Limited | Manufacturing | 2003 |
| Scaff Smart Ltd | Construction | 2022 |
| Scott Thompson Plumbing and Heating Services Ltd | Construction | 2025 |
| Seam Roofing Ltd | Construction | 2018 |
| Secure Automotive Ltd | Wholesale & retail | 2023 |
| Sepco Europe Limited | Wholesale & retail | 2015 |
| Sepco International Limited | Other services | 2015 |
| Sharni Shields Properties Ltd | Real estate | 2025 |
| Sheq Solutions Limited | Professional & scientific | 2016 |
| Shield Pro NE Community Interest Company | Arts & recreation | 2023 |
| Shilling Perry Group Limited | Wholesale & retail | 2020 |
| Skylark Commercial Services Limited | Professional & scientific | 2023 |
| SLK Services NE Ltd | Professional & scientific | 2018 |
| Smart Offers Ltd | Wholesale & retail | 2022 |
| Smart Sanitiser Limited | Wholesale & retail | 2020 |
| SMT Inspection Ltd | Manufacturing | 2025 |
| South Coast Swimming and Coaching Ltd | Education | 2026 |
| South Tyneside Healthwatch CIC | Health & social care | 2016 |
| Space I-D Limited | Professional & scientific | 2005 |
| Space ID Holdings Ltd | Real estate | 2020 |
| Space VR Limited | Professional & scientific | 2017 |
| Specialist Lifting Services Ltd | Professional & scientific | 2021 |
| Spice Colliery Ltd | Hospitality | 2016 |
| Stanley F Cutter Limited | Manufacturing | 2001 |
| Star 39 Limited | Hospitality | 2023 |
| Stennerscaffolding Ltd | Construction | 2025 |
| Stephen Pike Electrical Ltd | Construction | 2023 |
| STS Morton Ltd | Professional & scientific | 2021 |
| Surinder Properties Ltd | Real estate | 2023 |
| Swim Family Limited | Education | 2022 |
| Sydera Holdings Ltd | Financial services | 2022 |
| T Brow and Beauty Studio Limited | Other services | 2021 |
| TAJ Balti HUT Limited | Hospitality | 2014 |
| Talbot's Family Products UK LLP | | 2019 |
| Test.Mt Ltd | Information & communication | 2026 |
| THE Head Co. Group Limited | Wholesale & retail | 2023 |
| THE Parlour Boldon Ltd | Other services | 2009 |
| Timothy Elliott Fine Jewellery Limited | Wholesale & retail | 2011 |
| Total Resources (Holdings) Limited | Financial services | 2017 |
| Total Resources (UK) Limited | Other services | 2014 |
| Towndrow Health Ltd | Health & social care | 2024 |
| Trident Energy Solutions North East Limited | Construction | 2021 |
| Trotec Laser Limited | Wholesale & retail | 2006 |
| True Colours Financial Planning Limited | Financial services | 2005 |
| Truenorth Ecology Ltd | Professional & scientific | 2024 |
| TT PMC Limited | Extraterritorial | 2017 |
| Turbo Control Systems Ltd | Professional & scientific | 2018 |
| Turnbull Dwell Ltd | Real estate | 2023 |
| Turnbull Property Group Ltd | Real estate | 2025 |
| TWS Construction Services Ltd | Construction | 2023 |
| Tyne Coast Academy Trust | Education | 2012 |
| Tyne Tech Recruitment Limited | Administrative & support | 2025 |
| Ultimate Moto Limited | Wholesale & retail | 2010 |
| Universal Systems Solutions (Security) Limited | Construction | 2004 |