| Proper Cornish Retail Limited | Wholesale & retail | 2009 |
| Proper JOB PAT Testing Ltd | Professional & scientific | 2026 |
| PTT Hospitality Ltd | Hospitality | 2022 |
| Pugsley Limited | Administrative & support | 2005 |
| Pump Cover Ltd | Wholesale & retail | 2024 |
| Pumphrey & Weston Ltd | Construction | 2018 |
| Pure Vista Limited | Construction | 2007 |
| Purl Design Architecture Limited | Professional & scientific | 2014 |
| Puwer Ltd | Professional & scientific | 2025 |
| PVM Consultants Limited | Professional & scientific | 2008 |
| Pyourlife Ltd | Wholesale & retail | 2026 |
| Pyskessa Ltd | Information & communication | 2021 |
| QJ Energy Limited | Energy | 2015 |
| Quantsmiths Limited | Professional & scientific | 2022 |
| Quay Court (Management Company) Ltd | Households | 2015 |
| Quince Holdings South West Ltd | Real estate | 2024 |
| R H Taylor Ltd | Wholesale & retail | 2022 |
| R J Davey Homes Limited | Construction | 2005 |
| R S G Building Ltd | Construction | 2024 |
| R&D Developments 2021 Limited | Real estate | 2021 |
| R&R Cornwall Ltd | Real estate | 2016 |
| R.C.C. Roofing Limited | Construction | 2005 |
| Radford Consulting Ltd | Professional & scientific | 2024 |
| Radford Pyrotechnics Ltd | Information & communication | 2006 |
| RAE on RAE Ltd | Information & communication | 2005 |
| Ragged Trouser Productions Ltd | Manufacturing | 2006 |
| Rapid Network Services Limited | Information & communication | 2021 |
| Rawlings & Co (UK) Limited | Professional & scientific | 2019 |
| RDE Electrical Contractors Limited | Construction | 2008 |
| Reflections Cornwall Limited | Hospitality | 2021 |
| Reken Limited | Professional & scientific | 2022 |
| Remotebond Limited | Manufacturing | 1992 |
| Respryn Meadow Residents Bodmin Limited | Real estate | 2004 |
| RHD Holdings Cornwall Ltd | Real estate | 2026 |
| Richardson Martial Arts Ltd | Education | 2019 |
| RIGHT2MANAGE (UK) Ltd | Administrative & support | 2010 |
| Riley Garage Limited | Professional & scientific | 2008 |
| Risksol Ltd | Professional & scientific | 2025 |
| Riverside (Hellandbridge) Management Company Ltd | Households | 2020 |
| Riversmeet Management Limited | Households | 1990 |
| RLM Developments Ltd | Construction | 2021 |
| RLS Consultant Services Ltd | Administrative & support | 2018 |
| RNL Plumbing and Heating Ltd | Construction | 2023 |
| Robert Richard Hatton Ltd | Extraterritorial | 2024 |
| Robertjohngreen | Extraterritorial | 2024 |
| Rock Investment Services Limited | Administrative & support | 1990 |
| Rockset Group Ltd | Real estate | 2024 |
| Rocky Lane Cornwall Management Company Ltd | Households | 2010 |
| Rogers Space Heaters Limited | Wholesale & retail | 2015 |
| Rogerson Group Ltd | Wholesale & retail | 2026 |
| Romanian Community Bridge C.I.C. | Education | 2026 |
| Roofing Cornwall Ltd | Construction | 2018 |
| Rose Court Management (Truro) Ltd | Households | 2018 |
| Rosevale Gardens Residents Association Limited | Households | 2020 |
| Roundhouse Investments Ltd | Real estate | 2020 |
| Rowan & Sproull Limited | Professional & scientific | 2024 |
| Roze Suits Ltd | Wholesale & retail | 2025 |
| RSK Daily Essentials Ltd | Wholesale & retail | 2025 |
| RT Distribution Cornwall Ltd | Transport & logistics | 2018 |
| Rugged Interactive Limited | Manufacturing | 2017 |
| Rushbreed Limited | | 1991 |
| S & S Building Services Cornwall Ltd | Construction | 2018 |
| S Best Carpentry & Joinery Limited | Construction | 2014 |
| S Millett Electrical Limited | Construction | 2025 |
| S W Removals & Storage Ltd | Transport & logistics | 2021 |
| Sadleir Technical Consultancy Ltd | Professional & scientific | 1997 |
| Safer Stronger Communities | Health & social care | 2014 |
| Sagen Enterprises Ltd | Wholesale & retail | 2021 |
| Sally Heard and Associates Ltd | Professional & scientific | 2003 |
| Saltwater Construction Consultants Ltd | Professional & scientific | 2024 |
| Samar and Taneem Health Private Limited | Health & social care | 2025 |
| Samphire Construction Ltd | Construction | 2018 |
| Sana Ltd | Health & social care | 2026 |
| Sandoe & Sons Ltd | Agriculture & fishing | 2025 |
| Sara Wheeler Limited | Arts & recreation | 2023 |
| Sarah Barker Art Studios CIC | Wholesale & retail | 2025 |
| Sarena Cornwall Ltd | Energy | 2014 |
| Scene Stealers Rentals Ltd | Administrative & support | 2025 |
| Scott Bunce Ltd | Information & communication | 2014 |
| Scottkirkby Design Associates Limited | Arts & recreation | 1989 |
| Sea View Events Limited | Arts & recreation | 2025 |
| SEE Clean Contract Cleaning Services Limited | Administrative & support | 2014 |
| Seiners Perranporth Ltd | Hospitality | 2011 |
| Selectus Timber Frames Ltd | Wholesale & retail | 2025 |
| Send IT Cars and Competitions. Ltd | Arts & recreation | 2025 |
| Sert Property Ventures Ltd | Real estate | 2025 |
| Serving and Caring International | Education | 1999 |
| Sharob Care (Bude) Ltd | Health & social care | 2014 |
| Sharob Care Homes Ltd | Health & social care | 2004 |
| Sharon David Homes Ltd | Construction | 2020 |
| Sharon Lamerton's Care OR NOT Ltd | Information & communication | 2014 |
| Shaun Fitzpatrick DRY Lining Limited | Construction | 2018 |
| Shelley Property Holding (UK) Ltd | Real estate | 2014 |
| Shift Prints Ltd | Administrative & support | 2024 |
| Shine Through Window Cleaning Services Limited | Administrative & support | 2003 |
| Shute Farms Limited | Agriculture & fishing | 2015 |
| Signature Cornwall Ltd | Administrative & support | 2025 |
| Signature Signs Cornwall Ltd | Manufacturing | 2010 |
| Signatured Studios Ltd | Manufacturing | 2024 |
| Simon Brown Roofing Ltd | Construction | 2019 |