| Plaster Design Ryton Limited | Manufacturing | 2009 |
| Plentiful Marketing Co Limited | Professional & scientific | 2021 |
| PNC Property Ltd | Real estate | 2026 |
| Pons Aelius Design Limited | Professional & scientific | 2020 |
| Porters Pies Limited | Hospitality | 2026 |
| Powdertech Alloy Wheel Refurbishment Limited | Manufacturing | 2024 |
| Powdertech Motorsport Limited | Arts & recreation | 2024 |
| Precision SAW & Tool Limited | Manufacturing | 2007 |
| Premier GAS North East Ltd | Construction | 2024 |
| Premier Group North East Ltd | Real estate | 2024 |
| Premier Property North East Ltd | Real estate | 2024 |
| Premier Rents North East Ltd | Real estate | 2024 |
| Prestige Commercial Solutions Limited | Other services | 2008 |
| Prestige Valet NE Ltd | Administrative & support | 2024 |
| Primrose Gardens (Ryton) Management Company Limited | Real estate | 2006 |
| Profit Free Homes Community Interest Company | Other services | 2019 |
| Prosperity Holdings Group Ltd | Professional & scientific | 2024 |
| Proxiva Medical Ltd | Health & social care | 2026 |
| Pure Concierge Maintenance Ltd | Construction | 2019 |
| Pursuit Projects Limited | Professional & scientific | 2025 |
| PW Developments NE Limited | Real estate | 2023 |
| Pwl&C Ltd | Wholesale & retail | 2019 |
| PWS Electrical & Mechanical Services Limited | Manufacturing | 2022 |
| QPS North East Limited | Administrative & support | 2025 |
| Qualifyer Limited | Information & communication | 2025 |
| Quality Dynamix Limited | Professional & scientific | 2011 |
| Quality Instruments Ltd | Wholesale & retail | 2025 |
| Quickcareautocentres Ltd | Wholesale & retail | 2025 |
| Radiator Worx Limited | Construction | 2012 |
| Ranten Ltd | Information & communication | 2014 |
| RAY Gallon & SON Limited | Construction | 2012 |
| RD Holdings Ltd | Real estate | 2012 |
| Rdhl SPV1 Ltd | Real estate | 2020 |
| Rdhl SPV2 Ltd | Real estate | 2020 |
| Rdhl SPV3 Ltd | Real estate | 2020 |
| Rdhl SPV4 Ltd | Real estate | 2020 |
| Rdhl SPV5 Ltd | Real estate | 2025 |
| Red Kite Rentals (NE) Ltd | Administrative & support | 2024 |
| Reform Body Limited | Manufacturing | 2025 |
| Reformpadel for ALL CIC | Education | 2025 |
| Reformwear Limited | Wholesale & retail | 2025 |
| Revive Outdoor Adventures CIC | Education | 2026 |
| Riddens Transport Compliance Ltd | Transport & logistics | 2022 |
| Riversdale Care Consultancy Ltd | Professional & scientific | 2019 |
| Riversdale Homes Ltd | Construction | 2020 |
| RLA Electrical Services Limited | Construction | 2016 |
| ROD Services Ltd | Wholesale & retail | 2021 |
| Romano Restaurants Limited | Hospitality | 2024 |
| Rowal Limited | Construction | 2013 |
| Rowen Group Limited | Financial services | 2020 |
| Rowen Interior Design Limited | Professional & scientific | 2020 |
| Rutherford's Custom Built Ltd | Manufacturing | 2021 |
| Sabre Contracting Limited | Construction | 2019 |
| Safer Access Structures Limited | Construction | 2013 |
| SAI Investments Holding Ltd | Real estate | 2025 |
| Salome Designs Limited | Wholesale & retail | 2019 |
| Sama Sama International Community Interest Company | Administrative & support | 2023 |
| Sand Ventures Limited | Construction | 2019 |
| Satisfy My Soul Limited | Hospitality | 2024 |
| SB Specialist Consulting Ltd | Professional & scientific | 2026 |
| Selfbuild Services Limited | Construction | 2009 |
| Service Buddy Ltd | Information & communication | 2019 |
| SFM Design Group Limited | Financial services | 2022 |
| Side by Side Therapies CIC | Education | 2024 |
| Signature Blinds & Shutters Ltd | Wholesale & retail | 2019 |
| Silhouette Systems Limited | Information & communication | 2011 |
| Silverline Solutions (UK) Ltd | Construction | 2013 |
| Simmer & Soak Home Improvements Ltd | Professional & scientific | 2020 |
| SJ Machinery Solutions Limited | Wholesale & retail | 2024 |
| Slaters Electricals Limited | Manufacturing | 1946 |
| SMS Welding Systems Limited | Professional & scientific | 2019 |
| SON GAS Solutions Ltd | Construction | 2013 |
| Soothing Ideas Limited | Wholesale & retail | 2013 |
| Soph & Shine Ltd | Administrative & support | 2020 |
| Sorted NE Limited | Information & communication | 2022 |
| Sound Selection Ltd | Wholesale & retail | 2023 |
| Southern Insulation Solutions Ltd | Construction | 2016 |
| Speak Language School Ltd | Education | 2011 |
| Speak Ltd | Professional & scientific | 2016 |
| Spectrum Combined Services Limited | Construction | 2025 |
| Squeaky Clean (NE) Ltd | Wholesale & retail | 2025 |
| SSH Creative Ltd | Professional & scientific | 2025 |
| Starlux Automotive Group Limited | Wholesale & retail | 2023 |
| Stelicia Rehoboth Ltd | Wholesale & retail | 2025 |
| Stella Maintech Limited | Manufacturing | 2024 |
| Stone Electrical and Renewables Ltd | Construction | 2025 |
| Studio 52 NE Ltd | Professional & scientific | 2024 |
| Summer Houses 4U Ltd | Construction | 2024 |
| Sunderland Roofer Ltd | Construction | 2026 |
| Sunhill Ltd | Wholesale & retail | 2024 |
| Sure Purity Limited | Manufacturing | 2016 |
| Surgical Minds Ltd | Education | 2024 |
| Swalwell F.C C.I.C. | Other services | 2012 |
| Swedemade UK Limited | Construction | 2000 |
| Sycamore Consulting Ltd | Extraterritorial | 2025 |
| Syntonic Consulting Limited | Information & communication | 2001 |
| T&F Contracting Ltd | Information & communication | 2024 |
| T.I.T Property Developments Ltd | Real estate | 2025 |
| Takeone Consultancy Ltd | Information & communication | 2024 |
| Tan-Talize Beauty Ltd | Other services | 2006 |