| Pure Property Improvements Ltd | Real estate | 2022 |
| Purple Nova Inc. Limited | Professional & scientific | 2013 |
| Puvana Property Ltd | Real estate | 2018 |
| Qualitas Care & Support Limited | Health & social care | 2024 |
| Quality Car Repairs & MOT Center Limited | Wholesale & retail | 2023 |
| R & B Jefferies Limited | Real estate | 2024 |
| R & J C Bates Ltd | Construction | 2017 |
| R D Home Solutions Ltd | Construction | 2019 |
| R Davies Rentals Limited | Real estate | 2020 |
| R J Roofing and Cladding Ltd | Construction | 2021 |
| R L Landscaping and Driveways Limited | Construction | 2026 |
| Rachel Kathryn Residential Home Ltd | Health & social care | 2025 |
| Railzone Ltd | Construction | 2025 |
| RB Propertyfix Ltd | Construction | 2025 |
| RDJ Construction SW Ltd | Construction | 2026 |
| RDJ Demolition Ltd | Construction | 2026 |
| RDJ Groundworks Limited | Construction | 2021 |
| RDJ Group Holdings Ltd | Financial services | 2025 |
| RDJ Haulage Ltd | Transport & logistics | 2026 |
| RDJ Homes Ltd | Real estate | 2025 |
| RDJ Scaffolding Ltd | Construction | 2026 |
| React and Repair Ltd | Manufacturing | 2025 |
| Really Useful Stuff Ltd | Professional & scientific | 2025 |
| Red 10 Marketing Ltd | Professional & scientific | 2022 |
| Red Construction (SW) Ltd | Construction | 2023 |
| Redwood (ST. Mellons) Management Company Limited | Households | 2024 |
| Refresh Outdoors Limited | Administrative & support | 2026 |
| Refuel Nutrition Ltd | Hospitality | 2023 |
| Regan Brickwork Services Ltd | Construction | 2024 |
| Renewelec Energy Ltd | Construction | 2024 |
| Renewelec Ltd | Construction | 2024 |
| Renovationswales Ltd | Construction | 2021 |
| Repaireum Ltd | Wholesale & retail | 2023 |
| Retro Collectables Ltd | Wholesale & retail | 2018 |
| RH Blackwood Limited | Hospitality | 2025 |
| Rich Homes Property Investments Ltd | Real estate | 2026 |
| Richard Tuck Lettings Ltd | Real estate | 2008 |
| Risca United AFC Ltd | Arts & recreation | 2025 |
| Riverwood Housing Limited | Health & social care | 2008 |
| RJ Power Solutions Ltd | Construction | 2026 |
| RJM Mobile Vehicle Repairs Limited | Wholesale & retail | 2021 |
| RLE Estates Ltd | Real estate | 2022 |
| RLO Clothing Ltd. | Wholesale & retail | 2023 |
| RN Roberts (Whitchurch) Limited | Health & social care | 2006 |
| Roadrunner Motorco Ltd | Wholesale & retail | 2022 |
| ROB Wyman Homes Ltd | Construction | 2005 |
| Robert Johnstone ( Engineering ) Limited | Wholesale & retail | 2013 |
| Roberts Auto Repairs Recovery Limited | Wholesale & retail | 2026 |
| Rocco Plant Limited | Administrative & support | 2010 |
| Roman Valley Taxis Ltd | Transport & logistics | 2026 |
| Ross Canny Ltd | Wholesale & retail | 2025 |
| Rowan Tree Holdings Ltd | Real estate | 2026 |
| Rowlands Residential Ltd | Real estate | 2026 |
| Royaal Kebab (Blackwood) Ltd | Hospitality | 2025 |
| RS Taxis 17 Limited | Transport & logistics | 2017 |
| RSG Estates Ltd | Real estate | 2024 |
| RTY Engineering Ltd | Professional & scientific | 2026 |
| Ryan's Driving School Limited | Education | 2024 |
| S & C Limited | Professional & scientific | 1999 |
| S & F Cladding Solutions Ltd | Construction | 2024 |
| S a Davies Limited | Construction | 2019 |
| S Hogan Welding Ltd | Manufacturing | 2024 |
| S P Building and Hire Limited | Financial services | 2026 |
| S P Building Developments Limited | Construction | 2016 |
| S P Hire Limited | Administrative & support | 2015 |
| S&C @ Llanarth Limited | Hospitality | 2026 |
| S.A.T Utilities Ltd | Construction | 2017 |
| S.Howell Contractors Ltd | Financial services | 2018 |
| Sable and Cedar Ltd | Construction | 2025 |
| Saflia Global Limited | Manufacturing | 2022 |
| Saflia Limited | Other services | 2019 |
| Salvaged Creations Wales, I-Make, C.I.C. | Education | 2019 |
| Samson TV & Film Location Security Limited | Administrative & support | 2019 |
| Sapra Limited | Wholesale & retail | 2021 |
| Sate King Limited | Hospitality | 2019 |
| SAW Service Company Limited | Manufacturing | 1932 |
| SD Design Consultancy Limited | Professional & scientific | 2024 |
| Seabreeze Airconditioning Services Ltd | Construction | 2018 |
| Seda Pacprint (UK) Limited | Manufacturing | 1978 |
| Seda R.E. Limited | Manufacturing | 1989 |
| Seda UK Limited | Manufacturing | 1935 |
| Seft Group Limited | Administrative & support | 2023 |
| Sensory Cynfas CYF. | Hospitality | 2026 |
| Seren Controls Software Limited | Information & communication | 2021 |
| Sers (London & South East) Limited | Construction | 2003 |
| Sers (Solar & Renewable Technologies) Holdings Limited | Construction | 2011 |
| Sers (Solar & Renewable Technologies) Wales Limited | Construction | 2003 |
| Sers Energy Solutions Group Limited | Construction | 2003 |
| Sers Energy Solutions Holdings Limited | Financial services | 2012 |
| Sers Energy Solutions Limited | Construction | 1990 |
| Seymour Brothers Ltd | Real estate | 2025 |
| SH Hire & Groundworks Ltd | Construction | 2025 |
| Shampooch & Go Ltd | Other services | 2024 |
| Shear Devine Ltd | Other services | 2025 |
| Shelby 216 Ltd | Real estate | 2019 |
| Shelby Protect Ltd | Financial services | 2026 |
| Shelton Media Group Ltd | Information & communication | 2025 |
| Shetravels Ltd | Administrative & support | 2025 |
| Shiya Ltd | Wholesale & retail | 2019 |
| Shorties (Blackwood) Ltd | Wholesale & retail | 2026 |