| CS Room Hire Ltd | Hospitality | 2023 |
| CSJ Medical Services Ltd | Health & social care | 2021 |
| CSS Asbestos Ltd | Professional & scientific | 2026 |
| CT Joinery & Loft Conversions Ltd | Construction | 2021 |
| Cube Websites Ltd | Wholesale & retail | 2016 |
| Cugtechnology Limited | Information & communication | 2014 |
| Cummins Mellor H Limited | Professional & scientific | 2017 |
| Cupcakes by Sophia Ltd | Manufacturing | 2016 |
| Curaphyx Ltd | Wholesale & retail | 2026 |
| Curb Healthcare Ltd | Wholesale & retail | 2024 |
| Curiosity Classics Limited | Wholesale & retail | 2026 |
| Curious Space Ltd | Arts & recreation | 2012 |
| Curlew Projects Limited | Professional & scientific | 2013 |
| Curtainhouse Ltd | Manufacturing | 2026 |
| Curtis Law Estate Agents Limited | Real estate | 2017 |
| Curtis Law Group Limited | Professional & scientific | 2018 |
| Custom Upvc Windows Ltd | Construction | 2005 |
| Custom Workgear UK Ltd | Wholesale & retail | 2025 |
| Cutting Edge Engineering (Scotland) Limited | Manufacturing | 2000 |
| CVC (NW) Ltd | Wholesale & retail | 2022 |
| CVC Supplies Ltd | Wholesale & retail | 2020 |
| Cvvid Careers and Enterprise CIC | Information & communication | 2018 |
| Cvvid Limited | Administrative & support | 2012 |
| CW Bespoke Carpentry & Joinery Ltd | Construction | 2024 |
| CWI (Lancashire) Limited | Financial services | 2023 |
| Cyber & Digital Limited | Information & communication | 2019 |
| Cyber Defuse Ltd | Information & communication | 2020 |
| Cyber Security Clinic Ltd | Information & communication | 2024 |
| Cybernet Marketing Ltd | Wholesale & retail | 2021 |
| Cyberpoint Ltd | Information & communication | 2026 |
| Cycle Roots CIC | Water & waste | 2013 |
| Cygnus Resilience Limited | Professional & scientific | 2021 |
| Cyril Unsworth Limited | Arts & recreation | 1945 |
| D & C Enterprises Ltd | Hospitality | 2013 |
| D & D Auto Repairs Ltd. | Wholesale & retail | 2009 |
| D a Burton Property Ltd | Real estate | 2021 |
| D Alston Brickwork Ltd | Construction | 2020 |
| D and P Marketing Ltd | Administrative & support | 2021 |
| D C Filter Supplies Limited | Manufacturing | 2002 |
| D Chinese Food Kompany Ltd | Hospitality | 2020 |
| D Green PUB Ltd | Hospitality | 2024 |
| D M Bailey Ltd | Administrative & support | 2023 |
| D Wade Home Improvements Limited | Construction | 2023 |
| D&C (Lancs) Ltd | Construction | 2019 |
| D&J Agri and Plant Ltd | Wholesale & retail | 2024 |
| D&M Payments Ltd | Hospitality | 2025 |
| D&M Property (NW) Ltd | Real estate | 2025 |
| D&Tb Holdings Limited | Hospitality | 2022 |
| D. T. Allen Electrical Services Limited | Construction | 2005 |
| D.E.S. Facilities Management Group Limited | Administrative & support | 2002 |
| D.S.P. Building & Plumbing Services Limited | Construction | 2003 |
| D8069 CIC | Manufacturing | 2025 |
| DA Web Design Ltd | Wholesale & retail | 2025 |
| Dahe Ltd | Wholesale & retail | 2025 |
| Dahe Trading Ltd | Wholesale & retail | 2025 |
| Daher Properties Limited | Real estate | 2017 |
| Dahna Lounge Blackburn Ltd | Hospitality | 2020 |
| Dailupsolutionsuk Ltd | Wholesale & retail | 2025 |
| Daily Gifts Limited | Other services | 2017 |
| Dajajablackburn Ltd | Hospitality | 2025 |
| Dale Pharmacy Limited | Wholesale & retail | 2002 |
| Dalga UK Ltd | Wholesale & retail | 2025 |
| Dalvi Spice Quest Ltd | Wholesale & retail | 2024 |
| Dancolian Limited | Information & communication | 2023 |
| Dandal Ltd | Households | 2024 |
| DANDASERVICES25 Limited | Public administration | 2025 |
| Daneio Limited | Financial services | 2017 |
| Daneventures Ltd | Information & communication | 2018 |
| Daniel Thwaites (Trustee) Limited | Hospitality | 1998 |
| Daniel Thwaites Public Limited Company | Manufacturing | 1897 |
| Danley Engineering Services Limited | Manufacturing | 2014 |
| Dannai Enterprises Ltd | Wholesale & retail | 2025 |
| Danny Travels Ltd | Administrative & support | 2018 |
| Danyl Ltd | Transport & logistics | 2025 |
| DAR Apps Studio Ltd | Information & communication | 2025 |
| DAR Driving Assistance Limited | Education | 2023 |
| Dar-Ul-Madinah UK Ltd | Education | 2014 |
| Darlin Investments Limited | Administrative & support | 2015 |
| Darnell IT Solutions Limited | Information & communication | 2023 |
| Darron Sharples (Transport Solutions) Limited | Transport & logistics | 2011 |
| Darwen Carpets and Flooring Limited | Wholesale & retail | 2016 |
| Darwen Diesels Holdings Limited | Professional & scientific | 2009 |
| Darwen Diesels Limited | Wholesale & retail | 1971 |
| Darwen Essentials Limited | Wholesale & retail | 2025 |
| Darwen Estates Ltd | Real estate | 1998 |
| Darwen Foods Ltd | Other services | 2026 |
| Darwen Mini Mart Ltd | Wholesale & retail | 2018 |
| Darwen Motor Company Ltd | Wholesale & retail | 2025 |
| Darwen NO. 39 Ltd | Hospitality | 2025 |
| Darwen Private Hire Ltd | Other services | 2010 |
| Darwen Terracotta Limited | Manufacturing | 2015 |
| Darwen Terracotta Trustee Limited | Financial services | 2026 |
| Darwen Vehicle Services Limited | Wholesale & retail | 2025 |
| Darwen Wall Finishers Limited | Construction | 2015 |
| Darwen With Blackburn Private Hire Limited | Transport & logistics | 2012 |
| Dashu Ltd | Health & social care | 2013 |
| Dastgeer & Co Ltd | Administrative & support | 2013 |
| Data Driven Strategies Ltd | Information & communication | 2024 |
| Data Engine Group Ltd | Information & communication | 2026 |
| Datawalker Consultancy Limited | Information & communication | 2019 |