| Sprout Marketing Limited | Wholesale & retail | 2023 |
| Spudeli Limited | Hospitality | 2026 |
| Spyderbox Limited | Information & communication | 2021 |
| SQU4RED Developments Ltd | Real estate | 2023 |
| Square Root Labs Ltd | Information & communication | 2024 |
| Square Studio 49 Ltd | Professional & scientific | 2025 |
| SR Structural Ltd | Construction | 2024 |
| Srivastava Limited | Health & social care | 2020 |
| SRL Kitchen Ltd | Construction | 2026 |
| SRW Distribution Ltd | Wholesale & retail | 2024 |
| SS Business Growth Limited | Professional & scientific | 2020 |
| SSA Developments Ltd | Real estate | 2017 |
| Sslz Limited | Health & social care | 2022 |
| Ssvt Ltd | Wholesale & retail | 2025 |
| ST. Anselm's College Edmund Rice Academy Trust | Education | 2011 |
| Staffingsolutions Ltd | Education | 2026 |
| Staniford(Rock Ferry)Limited | Real estate | 1958 |
| Stanton Marine Limited | Other services | 1985 |
| Star Engineering Limited | Manufacturing | 2005 |
| Star Properties (Northwest) Ltd | Real estate | 2019 |
| Starlight Mobiles Ltd | Other services | 2024 |
| Starship Build Limited | Construction | 2020 |
| Starship Group Limited | Construction | 2022 |
| Starship Wirral Waters 1 Limited | Construction | 2021 |
| Statement Services Limited | Administrative & support | 2007 |
| STC Lean Consulting Limited | Professional & scientific | 1999 |
| Steadfast Building Services Ltd | Construction | 2013 |
| Stephen Healey Ltd | Construction | 2025 |
| Sterling Resolutions Ltd | Other services | 2025 |
| Steve Driscoll Limited | Information & communication | 2019 |
| Steve Edwards Education Ltd | Education | 2011 |
| Steve Fraser Consultancy Limited | Professional & scientific | 2020 |
| Steve Royston Limited | Other services | 2022 |
| Sticky Change (Consultants) Limited | Professional & scientific | 2004 |
| Sticky Change Limited | Professional & scientific | 1995 |
| Stone Electrical Services NW Limited | Construction | 2022 |
| Storeton Electrical Ltd | Construction | 2019 |
| Storytrender Limited | Extraterritorial | 2016 |
| Stratton Tax Ltd | Professional & scientific | 2024 |
| Streamline Portfolio Builders Ltd | Real estate | 2025 |
| Streamlined Construction NW Ltd | Construction | 2020 |
| Stredder Construction Group Ltd | Construction | 2020 |
| Strummers Limited | Hospitality | 2003 |
| Studio Bars Ltd | Hospitality | 2012 |
| Study Time Tutors Ltd | Education | 2016 |
| Stunt Performance Ltd | Arts & recreation | 2024 |
| Styleash Ltd | Wholesale & retail | 2024 |
| Substantiate Ltd | Professional & scientific | 2025 |
| Subzero Controlled Environments Ltd | Construction | 2026 |
| Suite Dreamz Limited | Wholesale & retail | 2021 |
| Summer Gusts Ltd | Wholesale & retail | 2022 |
| Summer Nutra Ltd | Wholesale & retail | 2024 |
| Summit Trade Network Ltd | Wholesale & retail | 2025 |
| Sunny & Sons Ltd | Public administration | 2016 |
| Sunny Nails & Spa 358 Ltd | Other services | 2024 |
| Sunrise Oriental Limited | Wholesale & retail | 2021 |
| Sunwah Tranmere Limited | Hospitality | 2020 |
| Sure Design Solutions Limited | Professional & scientific | 2017 |
| Sure Energy Solutions Ltd | Manufacturing | 2016 |
| Sure Refrigeration Solutions Ltd | Professional & scientific | 2017 |
| Sure SOL Holdings Limited | Financial services | 2019 |
| Sure SOL Properties Ltd | Real estate | 2022 |
| Sure Solutions Limited | Manufacturing | 2021 |
| Surface Repair Guys Ltd | Construction | 2023 |
| Survitec Acquisition Company Limited | Professional & scientific | 2014 |
| Survitec Global Solutions Limited | Professional & scientific | 2013 |
| Survitec Group Holdco Limited | Professional & scientific | 2020 |
| Survitec Group International Limited | Professional & scientific | 2013 |
| Survitec Group Limited | Manufacturing | 1967 |
| Survitec Safety Solutions UK Limited | Manufacturing | 2016 |
| Survitec Service & Distribution Limited | Manufacturing | 1955 |
| Sustain Safe Limited | Professional & scientific | 2025 |
| Swift Setup Services Ltd | Construction | 2025 |
| Swiftsort Ltd | Wholesale & retail | 2024 |
| Swithenbank Property Consultants (SPC) Ltd | Construction | 2008 |
| T & H Facilities Management Ltd | Administrative & support | 2022 |
| T&A Sushi Roll Limited | Hospitality | 2026 |
| T&J Joinery Services Ltd | Manufacturing | 2025 |
| T&L Metals UK Ltd | Water & waste | 2026 |
| T. H. Woodhouse & Co. Ltd | Real estate | 2008 |
| T.H.E Group Ltd | Transport & logistics | 2023 |
| T.S.J. Services Limited | Wholesale & retail | 2007 |
| Tabnel Limited | Other services | 2020 |
| Tabure Ltd | Hospitality | 2014 |
| Taffmash Limited | Health & social care | 2023 |
| Taffy's Carpets (N/W) Limited | Extraterritorial | 1997 |
| TAG Industrial Scaffolding Limited | Construction | 2013 |
| Tailor Recruitment Ltd | Administrative & support | 2021 |
| Tangerine Tooling Limited | Manufacturing | 2016 |
| Tanglin Developments Limited | Construction | 2015 |
| Tanin Limited | Hospitality | 2011 |
| Tank Sludge Technologies Ltd | Professional & scientific | 2025 |
| Tapethorn Limited | Households | 1988 |
| Tapton House Properties Ltd | Real estate | 2025 |
| Taste of Wirral Ltd | Hospitality | 2024 |
| Tax Essential Accountants Ltd | Professional & scientific | 2014 |
| Tayhope Limited | Manufacturing | 2024 |
| Taylor and Perry Garden Services Limited | Administrative & support | 2015 |
| Taylor's Property Wirral Ltd | Real estate | 2025 |
| Taylormade Construction (North West) Limited | Construction | 2012 |