| Smdg Ferrari Specialists Limited | Wholesale & retail | 2012 |
| Smdg Motorsport Limited | Wholesale & retail | 2018 |
| Smith Engineering & Management Ltd | Professional & scientific | 2020 |
| Smith Lettings Ltd | Real estate | 2024 |
| Snazzdup Ltd | Wholesale & retail | 2022 |
| Solar Metals Limited | Wholesale & retail | 2008 |
| Solent Bottled GAS Ltd | Extraterritorial | 2023 |
| Sommer Group Limited | Financial services | 2024 |
| Sommer Holdings Ltd | Professional & scientific | 1968 |
| Soqket Ltd | Information & communication | 2022 |
| South Reclamation Ltd | Water & waste | 2025 |
| Southdown’S Patisserie Ltd | Other services | 2025 |
| Southern Counties Tea & Coffee Co. Limited | Extraterritorial | 1996 |
| Spackman Consultants Ltd | Information & communication | 2023 |
| Sparr Farm Ltd | Agriculture & fishing | 2026 |
| Sparseset Ltd | Information & communication | 2023 |
| Spectrum International Exhibitions Limited | Manufacturing | 2025 |
| Speedy Pigs Limited | Professional & scientific | 2021 |
| Spiring Enterprises Limited | Manufacturing | 1967 |
| Spiritual Awareness CIC | Other services | 2023 |
| SSB Sussex Ltd | Hospitality | 2024 |
| ST. George Consultancy Limited | Construction | 2023 |
| Star Hypnotherapy Ltd | Other services | 2026 |
| Station Road Pizza Planet Ltd | Hospitality | 2024 |
| Steady Hands Logistics Ltd | Transport & logistics | 2024 |
| Steady Hands Removals Ltd | Transport & logistics | 2022 |
| Stonewall Cottage Management Company Limited | Real estate | 2006 |
| Strategic Risk Analysis Ltd | Professional & scientific | 2013 |
| Stratus Media Ltd | Information & communication | 2025 |
| Strax Productions Ltd | Information & communication | 2015 |
| Stvcoaching Ltd | Education | 2023 |
| Sublime Marketing Limited | Professional & scientific | 2005 |
| Sugarmoonfitness Ltd | Arts & recreation | 2022 |
| Summers Place Auctions Limited | Other services | 2007 |
| Super Colossal Ltd | Manufacturing | 2025 |
| Surrey Hills Collective Ltd | Other services | 2024 |
| Surrey Polo Ltd | Arts & recreation | 2014 |
| Susan Appleton Accountancy Limited | Professional & scientific | 2012 |
| Sussex Activities Ltd | Wholesale & retail | 2020 |
| Sussex Anodising Limited | Manufacturing | 2019 |
| Sussex Construction Group Limited | Extraterritorial | 2024 |
| Sussex Land Services Ltd | Other services | 2011 |
| Sussex Laundry Limited | Other services | 2011 |
| Sussex Residential Group Ltd | Real estate | 2026 |
| Sussex Spraying Specialists Ltd | Construction | 2021 |
| Suwannaphum Thai Cuisine Ltd | Hospitality | 2023 |
| SW Education Limited | Education | 2017 |
| Sweat Creative Limited | Professional & scientific | 2010 |
| Swedev (UK) Limited | Manufacturing | 2003 |
| Sylva Treecare Ltd | Agriculture & fishing | 2026 |
| Sylvania Management Company Limited | Construction | 2011 |
| Syntrisi Conservation Ltd | Construction | 2026 |
| Syringa UK Ltd | Professional & scientific | 2010 |
| System Compliance Ltd | Professional & scientific | 2020 |
| T & H Logs Ltd | Agriculture & fishing | 2022 |
| T HM Cole’S Ltd | Construction | 2022 |
| Tandem Business Services Ltd | Professional & scientific | 2025 |
| Targett Gardening Services Ltd | Administrative & support | 2016 |
| Tathsa Zabejevi Ltd | Financial services | 2023 |
| Tayratbag 1963 Limited | Extraterritorial | 2014 |
| Teal Digital Communications Ltd | Information & communication | 2026 |
| Teal Property Agency Ltd | Real estate | 2026 |
| Teal Property Development Ltd | Construction | 2026 |
| Tedfold Residents Association Limited | Households | 1999 |
| Teeth With Tessa Limited | Health & social care | 2021 |
| Telefónica Tech UK TOG Limited | Professional & scientific | 1998 |
| TEN Risk Management Limited | Financial services | 2015 |
| Terbell Limited | Other services | 2002 |
| Tessa JW Holdings Limited | Financial services | 2024 |
| Thai Chef PT Ltd | Hospitality | 2025 |
| Thakeham Advanced Limited | Manufacturing | 2021 |
| Thakeham Burgess Hill LLP | | 2022 |
| Thakeham Homes (Pease Pottage) Limited | Construction | 2018 |
| Thakeham Homes (Southern) Limited | Construction | 2003 |
| Thakeham Homes Limited | Construction | 2010 |
| Thakeham Number SIX LLP | | 2024 |
| Thakeham Partnerships Limited | Construction | 2012 |
| Thakeham Pease Pottage LLP | | 2018 |
| Thakeham Strategic Ltd | Construction | 2020 |
| Thames House (Cost Sale) Limited | Real estate | 1981 |
| THE 5 to 8 Property Management Company Limited | Hospitality | 1999 |
| THE AG Village Road Management Company Limited | Households | 1999 |
| THE Business Travel Network Ltd | Administrative & support | 2018 |
| THE Clear Tree Limited | Information & communication | 2014 |
| THE Clutterflies Limited | Other services | 2022 |
| THE Crèche Limited | Health & social care | 2025 |
| THE Dog Way Limited | Professional & scientific | 2013 |
| THE Drovers Daughter Ltd | Manufacturing | 2023 |
| THE Fine and Rare Spirits Company Limited | Wholesale & retail | 2022 |
| THE Hollies (Horsham) Management Company Ltd | Households | 2012 |
| THE Iberian Experience Ltd | Administrative & support | 2025 |
| THE Limeburners Billingshurst Limited | Hospitality | 2019 |
| THE Lion Logistics Ltd | Transport & logistics | 2024 |
| THE Little Bean Cafe Limited | Administrative & support | 2017 |
| THE Livestock Clinic Ltd | Professional & scientific | 2020 |
| THE Livestock Partnership Limited | Professional & scientific | 2011 |
| THE Motion Factory Ltd | Information & communication | 2010 |
| THE OD Agency Limited | Administrative & support | 2016 |
| THE Omega 3 Zone Limited | Extraterritorial | 2020 |
| THE Only Network Ltd | Wholesale & retail | 2022 |