| S H Tiling & Bathrooms Ltd | Construction | 2021 |
| S J Wills Ltd | Professional & scientific | 2024 |
| S V Carter Limited | Construction | 2005 |
| S&J Holdings (SE) Limited | Real estate | 2022 |
| S&S Vaughan Ltd | Other services | 2014 |
| S'Ir Tailor Master Tutor Limited | Education | 2011 |
| S. Brown Properties Limited | Real estate | 2019 |
| S. I. Pumps Limited | Manufacturing | 1986 |
| S. Jackson Interiors Limited | Construction | 2004 |
| S.L. Technical Limited | Manufacturing | 2002 |
| S12 Property Developments Limited | Construction | 2016 |
| S2 Construction Limited | Construction | 2013 |
| Saandre Konsult Limited | Professional & scientific | 2019 |
| Saatra Ltd | Water & waste | 2021 |
| SAB Business Solutions Limited | Information & communication | 2015 |
| Sabainang Company Limited | Hospitality | 2024 |
| Sabe Technology Limited | Professional & scientific | 2019 |
| Saboa Ltd | Wholesale & retail | 2022 |
| Sabre Advanced Electronics Limited | Wholesale & retail | 2012 |
| Sabre Advanced Micro Electronics Limited | Wholesale & retail | 1990 |
| Sacha Leyla Webb Ltd | Extraterritorial | 2023 |
| Sadler Talbot Ltd | Professional & scientific | 2003 |
| Safegreen Electrical Limited | Construction | 2014 |
| Safeguard Secure Solutions Ltd | Construction | 2010 |
| Safety and Support Ltd | Professional & scientific | 2023 |
| Saffy's State Ltd | Real estate | 2025 |
| Sahyadri Tech Limited | Information & communication | 2024 |
| Saicozy Homes Ltd | Real estate | 2024 |
| Saific Terra Ltd | Real estate | 2025 |
| Saje Properties LLP | | 2017 |
| Saker Controls Limited | Construction | 2001 |
| Sales Science Ltd | Manufacturing | 2006 |
| Salford Leisure Limited | Hospitality | 2019 |
| Salunda Limited | Professional & scientific | 2004 |
| SAM Cars 247 Ltd | Transport & logistics | 2014 |
| SAM Rigby Consulting Ltd | Information & communication | 2024 |
| Sam's Old School Barber Ltd | Other services | 2019 |
| Samarko Company Limited | Wholesale & retail | 2021 |
| Sambazon, Ltd. | Wholesale & retail | 2015 |
| Samsi Property Ltd | Construction | 2023 |
| SAN Oriental Limited | Wholesale & retail | 2019 |
| Sanctum Build Ltd | Construction | 2025 |
| Sand Property Management Limited | Real estate | 2020 |
| Sanders Electrical Solutions Ltd | Construction | 2019 |
| Sandra Homewood Funerals (Bicester) Ltd | Other services | 2017 |
| Sandra Homewood Funerals (Oxford) Ltd | Other services | 2017 |
| Sandra Homewood Group Ltd | Other services | 2017 |
| Sandra Homewood Memorials Ltd | Other services | 2017 |
| Sandro Investment Properties Limited | Real estate | 2023 |
| Sandy Schnoodle Limited | Hospitality | 2024 |
| Sansa Logistics Ltd. | Transport & logistics | 2024 |
| Santana Motor UK Ltd | Wholesale & retail | 2018 |
| Santos Solutions Ltd | Information & communication | 2012 |
| Sapien Trailers Limited | Manufacturing | 2024 |
| Sapphire Spas Limited | Wholesale & retail | 2005 |
| Sardonyx Investments Ltd | Real estate | 2023 |
| Saretius Limited | Professional & scientific | 2008 |
| Savannah Investment Properties Limited | Real estate | 2023 |
| Savoir Fare Limited | Hospitality | 2014 |
| Sawsense Limited | Professional & scientific | 2023 |
| Sbgp Limited | Information & communication | 2025 |
| Scandinavian Machine Vision Solutions Ltd | Manufacturing | 2012 |
| Scenic Farms Limited | Agriculture & fishing | 2017 |
| Scenic Land Developments Limited | Real estate | 2007 |
| Scent Dog Training LLP | | 2023 |
| Scott Mitchell | | 1990 |
| Scotties Solicitors Limited | Professional & scientific | 2021 |
| Scryptiq Ltd | Education | 2025 |
| SD Accountancy Ltd | Professional & scientific | 2024 |
| SDC Readings Ltd | Administrative & support | 2015 |
| SDE Engineering Services Ltd | Professional & scientific | 2011 |
| Sdlt Experts Ltd | Professional & scientific | 2021 |
| SE Dental Services Limited | Health & social care | 2023 |
| Seagreen Contracts Ltd | Construction | 2012 |
| Seasonal Ventures UK Ltd | Professional & scientific | 2023 |
| Seasons Hospitality Ltd | Hospitality | 2022 |
| Seatech Technologies Ltd | Information & communication | 2013 |
| Seba Transport Limited | Transport & logistics | 2021 |
| Secure Sphere Holding Ltd | Administrative & support | 2025 |
| Securerelm Ltd | Information & communication | 2019 |
| Seek & SEW Ltd | Manufacturing | 2018 |
| Seismar Ltd. | Professional & scientific | 2017 |
| Sempil Capital Limited | Mining & quarrying | 2026 |
| Send Network Ltd | Education | 2024 |
| Sense Cooperation Limited | Professional & scientific | 2021 |
| Senya Limited | Information & communication | 2005 |
| Sequora Ltd | Information & communication | 2025 |
| Serious Enterprises Limited | Manufacturing | 2014 |
| Serjan Ltd | Construction | 2017 |
| Servicefindr Ltd | Professional & scientific | 2022 |
| SET Connection Limited | Arts & recreation | 2004 |
| SET Sail Cruises Ltd | Administrative & support | 2026 |
| Seven Mile Cookery & Events Limited | Hospitality | 2016 |
| Severn Properties Limited | Construction | 2017 |
| SG Eyecare Ltd | Health & social care | 2024 |
| SG Staffmotion Ltd | Other services | 2025 |
| SGA Entertainment Ltd | Wholesale & retail | 2017 |
| SGB Logistics Ltd | Transport & logistics | 2023 |
| Shack Consulting Limited | Professional & scientific | 2019 |
| Shake + Bake Ltd | Professional & scientific | 2017 |