| Smith Food Solutions Limited | Hospitality | 2012 |
| Smokers Paradise PG Limited | Wholesale & retail | 2020 |
| SMP Pharma Limited | Financial services | 2018 |
| SMP Real Estate Limited | Real estate | 2025 |
| SMY Electrical Contractor Ltd | Construction | 2013 |
| Snack on Site Catering UK Ltd | Hospitality | 2026 |
| Snvbae Limited | Hospitality | 2026 |
| Solar Marine Services Limited | Transport & logistics | 2001 |
| Solar Milele Limited | Wholesale & retail | 2022 |
| Solcom Associates Ltd | Information & communication | 2020 |
| Soni Great Coat Ltd | Construction | 2025 |
| Sonof Ltd | Construction | 2016 |
| Soruk Limited | Energy | 2014 |
| Soteria Auto Doors Ltd | Manufacturing | 2023 |
| Sourcemeta Ltd | Professional & scientific | 2022 |
| South East Lofts Ltd | Construction | 2024 |
| South East London Tennis C.I.C. | Arts & recreation | 2011 |
| South East Resto Limited | Extraterritorial | 2017 |
| Southern Heating Ltd | Construction | 2017 |
| Southland Investment Group Ltd | Construction | 2025 |
| Southtech Consulting Ltd | Information & communication | 2025 |
| Southtech Finance Ltd | Professional & scientific | 2026 |
| Southwest Builders (London) Limited | Construction | 2013 |
| Spadeground Limited | Wholesale & retail | 1979 |
| Spectron Property Limited | Extraterritorial | 1994 |
| Spectrum Graphics (GB) Limited | Information & communication | 2010 |
| Speedy Haul Couriers Ltd | Transport & logistics | 2026 |
| Spider Core Security Ltd. | Administrative & support | 2018 |
| Spier's Salads Ltd. | Hospitality | 2017 |
| Spillers Maintenance Services Ltd | Extraterritorial | 2017 |
| Spindle Developments Management Company Limited | Households | 2022 |
| Spires Residents Association Limited(The) | Real estate | 1964 |
| Spudbae Events Ltd | Hospitality | 2025 |
| Squared Global Limited Limited | Professional & scientific | 2025 |
| SR Care Point Ltd | Health & social care | 2023 |
| SR8 Properties Ltd | Real estate | 2013 |
| SRI Hari Consultants Ltd | Professional & scientific | 2023 |
| SRI SAI Properties Limited | Real estate | 2025 |
| Srig Accountants Ltd | Professional & scientific | 2024 |
| Sskp Pharmaceuticals Ltd | Wholesale & retail | 2024 |
| Ssrdfire Ltd | Construction | 2026 |
| Ssrdrec Ltd | Administrative & support | 2026 |
| ST George Greek Taverna Ltd | Hospitality | 2023 |
| ST Georges MOT Centre Ltd | Wholesale & retail | 2026 |
| ST Paulinus PRE School Limited | Health & social care | 2022 |
| Stafford Court (Bexley) Management Limited | Real estate | 2005 |
| Stand-Time Media Ltd | Information & communication | 2025 |
| Star Circle Consulting Ltd | Professional & scientific | 2025 |
| Star DKP Limited | Professional & scientific | 2021 |
| Starship FOX Ltd | Education | 2026 |
| Statement Crystals Ltd | Wholesale & retail | 2024 |
| Stay in Focus Limited | Real estate | 2015 |
| Staybele Homes Ltd | Hospitality | 2025 |
| Stealthedeal Limited | Wholesale & retail | 2025 |
| Steeltech (South East) Limited | Professional & scientific | 2012 |
| Stellar Stone Limited | Manufacturing | 2023 |
| Stephen Pooley Limited | Construction | 2014 |
| Stephen Talbot Interiors Ltd. | Professional & scientific | 2013 |
| Sterling Williams Limited | Administrative & support | 2023 |
| Steve Rice Limited | Manufacturing | 2005 |
| Steve Roberts Military Ancestry Ltd | Arts & recreation | 2010 |
| Stewart Truman Developments Limited | Construction | 2022 |
| Stewart Truman Holdings Limited | Construction | 2022 |
| Stewart Truman Masonry Limited | Construction | 2022 |
| Stgg LLP | | 2015 |
| Stluciamixedgeneration Ltd | Other services | 2024 |
| Stone Hair Salon Limited | Other services | 2010 |
| Store 2 Door Holdings Limited | Administrative & support | 2016 |
| Strategic Innovation Services Limited | Information & communication | 2015 |
| Strategix Consultancy Ltd | Education | 2023 |
| Stride Again Tech Ltd | Wholesale & retail | 2025 |
| Strike Scaffolding London Limited | Construction | 2016 |
| String of Pearls Property Limited | Construction | 2003 |
| Structure Limited | Information & communication | 1996 |
| Stuarts Recycling Services Limited | Extraterritorial | 2009 |
| Studio Balneo Kitchens Ltd | Construction | 2024 |
| Studio Balneo Ltd | Construction | 2018 |
| Studio Woodford Ltd | Professional & scientific | 2023 |
| Subseaquence Limited | Administrative & support | 2013 |
| Sugars Desserts Limited | Hospitality | 2024 |
| Summit Arora Ltd | Information & communication | 2020 |
| Sunny JIM Films Limited | Information & communication | 2000 |
| Supershield Limited | Construction | 1994 |
| Sure IT Recruitment Limited | Administrative & support | 2002 |
| Surefire Kent Ltd | Other services | 2016 |
| Sureview Green Energy Ltd | Construction | 2024 |
| Sureview Services Ltd | Construction | 2018 |
| Surrey Healthcare Solutions Ltd. | Wholesale & retail | 2011 |
| Sustainable Tech Ltd | Real estate | 2019 |
| Suzie Quill Limited | Professional & scientific | 2017 |
| Swanscombe Business Centre Limited | Professional & scientific | 1977 |
| Sward Consulting Ltd | Professional & scientific | 2025 |
| Sweetwise Ltd | Wholesale & retail | 2009 |
| Syasil Marketing Limited | Wholesale & retail | 2025 |
| Syira Limited | Real estate | 2025 |
| Synapse Power AI Ltd | Information & communication | 2025 |
| Synergy Aesthetics Bexley Ltd | Other services | 2022 |
| Syracuse Education Limited | Education | 2025 |
| Syvoda Limited | Health & social care | 2018 |
| T & N Heating Services Limited | Construction | 2015 |