| Ethos Medical Care Limited | Health & social care | 2015 |
| Evengain Limited | Professional & scientific | 1990 |
| Everdental Bexhill Limited | Health & social care | 2024 |
| Everdental Eastbourne Limited | Health & social care | 2024 |
| Everdental Limited | Health & social care | 2013 |
| Eversley RD Management Limited | Households | 2013 |
| Eversley Road 30 Ltd | Administrative & support | 2018 |
| Evolved Learning Ltd. | Wholesale & retail | 2017 |
| EW Funeral Services Limited | Other services | 2016 |
| Exemplar People Limited | Administrative & support | 2010 |
| Exit Solution Group Limited | Real estate | 2020 |
| Exodus Recordings Ltd | Wholesale & retail | 2026 |
| Expert in Mind Limited | Administrative & support | 2008 |
| Express Removals Worldwide Ltd | Transport & logistics | 2013 |
| F M Global Investments Ltd | Real estate | 2012 |
| Fablight Ltd | Manufacturing | 2020 |
| Fabulous Frank Limited | Professional & scientific | 2016 |
| Facilities Management Complete Limited | Administrative & support | 2012 |
| Factorgold Residents Association Limited | Households | 1991 |
| Factory Internet Ltd | Administrative & support | 2011 |
| Faris Group Holdings Ltd | Financial services | 2026 |
| Faris Group Investments Limited | Real estate | 2026 |
| Farman Investment Limited | Real estate | 2023 |
| Farman Property Management LLP | | 2023 |
| Farthings Syndicate Limited | Agriculture & fishing | 1985 |
| FBA Invest Real Estate Ltd | Real estate | 2021 |
| Feel Energised Martial Arts Ltd | Education | 2023 |
| Fendale Ltd | Wholesale & retail | 2006 |
| Fertility Network UK | Other services | 2003 |
| Fetish Freak Limited | Wholesale & retail | 2007 |
| FF Retail Limited | Wholesale & retail | 2007 |
| FGC European Consulting Ltd | Professional & scientific | 2022 |
| FHC Healthcare Ltd | Administrative & support | 2023 |
| Fiducia Security Services Limited | Administrative & support | 2019 |
| FINACC1 Solutions Ltd | Financial services | 2023 |
| Final Touch Smart Repairs Ltd | Wholesale & retail | 2020 |
| Finaxis Ltd | Extraterritorial | 2009 |
| Findley & SON (Cooden) Limited | Real estate | 2008 |
| Findley's of Cooden Limited | Real estate | 2018 |
| Findley's Secretarial Services Limited | Administrative & support | 2020 |
| Firgrove Property Developments Limited | Real estate | 2021 |
| First Call Inks Limited | Wholesale & retail | 2007 |
| FIS Limited | Administrative & support | 2025 |
| Fish & Meat House Limited | Hospitality | 2025 |
| Fit and Learn Limited | Education | 2015 |
| Fit Sports Ltd | Wholesale & retail | 2016 |
| Fitness Industry Services CIC | Information & communication | 2020 |
| Fitness Rave Ltd | Other services | 2020 |
| Fitzrovia Building and Maintenance Ltd | Construction | 2023 |
| Fitzrovia Group Holdings Limited | Health & social care | 2024 |
| Five Property (South East) Limited | Real estate | 2023 |
| Five Star Nails (Bexhill-On-Sea) Limited | Other services | 2025 |
| Fizzy Apple Ltd | Professional & scientific | 2018 |
| Fk.It Ltd | Wholesale & retail | 2021 |
| Flair and Rewear Limited | Wholesale & retail | 2022 |
| Flatland Projects CIC | Arts & recreation | 2020 |
| Flatsave Limited | Households | 1994 |
| Flawlessfloors Hastings Ltd | Wholesale & retail | 2017 |
| Flexion Services Ltd | Administrative & support | 2025 |
| Floors by Thompson Ltd | Construction | 2026 |
| Florence Annette Hurley Limited | Extraterritorial | 2025 |
| Flux Broadcast Limited | Information & communication | 2014 |
| Foam Insulations Limited | Construction | 2013 |
| Foragers Rest Ltd | Hospitality | 2025 |
| Ford Golf Design Limited | Arts & recreation | 2007 |
| Foredeck Limited | Professional & scientific | 2008 |
| Forestheath Engineering Limited | Manufacturing | 2008 |
| Foretti Limited | Information & communication | 2015 |
| Forge & Flora Limited | Manufacturing | 2020 |
| Forge Evolutions Ltd | Construction | 2011 |
| Forge Holdings and Developments Ltd | Construction | 2022 |
| Forno 33 Ltd | Hospitality | 2023 |
| Forward Thermal & Flow Ltd | Construction | 2026 |
| Foxley Little Common Limited | Real estate | 2015 |
| Frampton & Co (Sussex) Limited | Professional & scientific | 2003 |
| Francesca Mather Limited | Professional & scientific | 2017 |
| Freedom Tree Ltd | Real estate | 2020 |
| Freerose Construction Ltd | Construction | 2026 |
| Fresh View Studio Ltd | Professional & scientific | 2025 |
| Freshfield Properties Limited | Real estate | 1980 |
| Frontier Sierra Holdings Ltd | Wholesale & retail | 2025 |
| Frontrow Communications Limited | Professional & scientific | 2000 |
| Frugooweb Limited | Information & communication | 2025 |
| FT Care Agency Limited | Health & social care | 2023 |
| Fullbrook Strategies Limited | Professional & scientific | 2022 |
| Fullers Roofing (Sussex) Limited | Construction | 2012 |
| Fupi West Limited | Professional & scientific | 2024 |
| Furness Controls Limited | Manufacturing | 1964 |
| Fursdon Consulting Services Ltd | Professional & scientific | 2025 |
| Fursdon Holdings Ltd | Professional & scientific | 2025 |
| Furze Property Management Limited | Households | 1995 |
| Fusion Groundscape Solutions Limited | Construction | 2023 |
| Future Business Partnership Limited | Extraterritorial | 2010 |
| Future Glazing (South East) Limited | Construction | 2025 |
| G & P (Bexhill on Sea) Ltd. | Hospitality | 2015 |
| G&E Trading Limited | Wholesale & retail | 2016 |
| G&T Southern Property Limited | Real estate | 2023 |
| G-Staff Recruitz Healthcare Limited | Health & social care | 2021 |
| G.C. Dannicks Limited | Construction | 2007 |
| G.O.A.T Burger & Grill Limited | Hospitality | 2022 |