| David H. Smith Funeral Directors (Inc. Mellor & Smith) Limited | Other services | 2001 |
| David Hodges Transport Limited | Transport & logistics | 2005 |
| Davton Limited | Information & communication | 2005 |
| Dawesy Developments Ltd | Real estate | 2023 |
| DD Healthcare (Yorkshire) Limited | Health & social care | 2022 |
| DDR Consultants Ltd | Professional & scientific | 2009 |
| DE Lacy at Home Ltd | Wholesale & retail | 2024 |
| DE Lacy Beauty Beverley Limited | Other services | 2011 |
| DE Lacy Beauty Limited | Other services | 2010 |
| DE Lacy Hair Beverley Limited | Other services | 2014 |
| DE Lacy Hair Limited | Other services | 2010 |
| DE Lacy Hair Willerby Ltd | Other services | 2011 |
| DE Lacy Spa Limited | Other services | 2007 |
| Dean Conrad Ltd | Information & communication | 2018 |
| Deeksha Limited | Real estate | 2026 |
| Deep Blue Sea (Beverley) Limited | Hospitality | 2025 |
| Delaney Marling Partnership Limited | Professional & scientific | 2007 |
| Delta Charlie Group Ltd | Real estate | 2023 |
| Delta Management Company (Beverley) Limited | Households | 2006 |
| Deluxebase Limited | Wholesale & retail | 1994 |
| Demir and Demir Limited | Hospitality | 2016 |
| Denim Boots Coffee Ltd | Hospitality | 2025 |
| Dennis Winter (Leven) Limited | Wholesale & retail | 1965 |
| Denston Forklift Limited | Manufacturing | 2020 |
| Dent Remover Limited | Wholesale & retail | 2018 |
| Dent-Tech PDR Ltd | Wholesale & retail | 2019 |
| Denton Street Management Company Limited | Administrative & support | 1997 |
| Derbybeech Limited | Construction | 1978 |
| Detail Travel Ltd | Administrative & support | 2019 |
| Deva Maintenance Services Ltd | Manufacturing | 2024 |
| DH & JS Properties Ltd | Real estate | 2020 |
| Dhte Consulting Ltd | Professional & scientific | 2024 |
| Dialfit Limited | Households | 1988 |
| Dialsleave Limited | Agriculture & fishing | 1976 |
| Diamond Star Solutions Ltd | Information & communication | 2019 |
| Dick Cunningham Interiors Ltd | Hospitality | 2018 |
| Dick Cunningham Ltd | Hospitality | 2013 |
| Dieselpump UK Ltd | Professional & scientific | 2015 |
| Digital Converting Consultancy Limited | Information & communication | 2014 |
| Digital Measuring Technologies Ltd | Professional & scientific | 2026 |
| DIGS4ME Ltd. | Hospitality | 2011 |
| Discount Florida Car Hire Limited | Administrative & support | 2017 |
| Discount Tyre Warehouse (Hull) Ltd | Wholesale & retail | 2012 |
| Ditto 4 Design Ltd. | Manufacturing | 2002 |
| Ditto Holdings Ltd | Financial services | 2018 |
| DJB Inspection Ltd | Professional & scientific | 2026 |
| DJF Trading Limited | Manufacturing | 2008 |
| DK Heat Recovery Ltd | Manufacturing | 2012 |
| DKJ Health Hub Limited | Other services | 2024 |
| DKJ Support Services Ltd | Information & communication | 2015 |
| Dkpengineering Limited | Professional & scientific | 2025 |
| DM Shoe Co Limited | Wholesale & retail | 2024 |
| Dmsa Wind Ltd | Manufacturing | 2026 |
| DMW Property Ltd | Real estate | 2023 |
| DN Property Holdings Ltd | Real estate | 2023 |
| DNY Property Ltd | Real estate | 2025 |
| Dog and Duck Flamborough Ltd | Hospitality | 2025 |
| Dolce Vita (Beverley) Ltd | Hospitality | 2016 |
| Dominic Hart PT Ltd | Health & social care | 2024 |
| Dominion Navigation SA Ltd | Administrative & support | 2015 |
| Doms Limited | Wholesale & retail | 2003 |
| Doncaster Funeral Services Limited | Other services | 1970 |
| Doogie Stuff Holdings Ltd | Financial services | 2020 |
| Doogie Stuff Limited | Manufacturing | 2011 |
| Douglas Management Consultancy Limited | Professional & scientific | 2008 |
| Dpkl Limited | Construction | 2012 |
| DR Abigail Chapman Ltd | Health & social care | 2025 |
| DR Philip Buckley Anaesthetic Services Limited | Health & social care | 2021 |
| DR S Faruqi Limited | Health & social care | 2016 |
| Dragonfly Children's Services Limited | Health & social care | 2010 |
| Dramatic Theatre CIC | Education | 2020 |
| Drawing Court Limited | Extraterritorial | 2010 |
| Drawing Group Assets LLP | | 2010 |
| Dream Science Limited | Professional & scientific | 2000 |
| Dreams on Wheels Ltd | Administrative & support | 2021 |
| Driffield Properties Limited | Real estate | 1983 |
| DRJ Green Ltd | Real estate | 2025 |
| Drypool Commercial Ltd | Wholesale & retail | 2022 |
| Dstq Limited | Real estate | 2015 |
| DTR Technical Services Ltd | Professional & scientific | 2021 |
| Ducemus Viam Ltd | Information & communication | 2026 |
| Dumble Farm Limited | Wholesale & retail | 2022 |
| Durham Court Flats Association Limited(The) | Households | 1983 |
| Dymond Accountants Limited | Professional & scientific | 2018 |
| Dynamic Growth Ltd | Professional & scientific | 2023 |
| Dynamic People Solutions Limited | Administrative & support | 2020 |
| DYS Energy Limited | Construction | 2024 |
| E & E K Developments Limited | Construction | 2023 |
| E & M Developments Ltd | Construction | 2025 |
| E Hill & SON Limited | Other services | 2019 |
| E Hoggard & Sons Limited | Construction | 2008 |
| E W Higgins & SON (Holdings) Ltd | Financial services | 2014 |
| E&M Equestrian Supplies Ltd | Wholesale & retail | 2024 |
| E.Brown & SON (Transport) Limited | Transport & logistics | 2002 |
| E5 Fitness Limited | Other services | 2020 |
| EA Boards Limited | Construction | 2023 |
| Eacon Engineers Ltd | Professional & scientific | 2002 |
| EAR Clear (East Yorkshire) Ltd | Health & social care | 2026 |
| East Coast Living Limited | Real estate | 2017 |
| East Riding Aesthetics Limited | Health & social care | 2014 |