| RS Sports Management Ltd | Arts & recreation | 2019 |
| RTS Horticulture Limited | Administrative & support | 2008 |
| Rugby Self Store Limited | Professional & scientific | 2018 |
| Rushforth Estates Limited | Information & communication | 2018 |
| Russell Garn Ltd | Extraterritorial | 2017 |
| Russell Hicks Limited | Arts & recreation | 2024 |
| Ryan Parkins Limited | Information & communication | 2015 |
| Ryeley Group Limited | Other services | 2025 |
| S & K Investment Properties Limited | Real estate | 2025 |
| S & R Pumps Limited | Extraterritorial | 2000 |
| S Barnes Consulting Limited | Administrative & support | 2008 |
| S K S Limited | Wholesale & retail | 1972 |
| S Mccarthy Carpentry Limited | Construction | 2003 |
| S Murphy & Sons Ltd | Construction | 2010 |
| S P Letting Ltd | Real estate | 2017 |
| S Smith Premier Ltd | Wholesale & retail | 2020 |
| S.Brennan Bespoke Ltd | Other services | 2024 |
| SA Residences (Gb&I) Limited | Real estate | 2018 |
| Saba & Saba London Limited | Real estate | 2017 |
| Saba & Saba Ltd | Real estate | 2017 |
| Safe & Secure Events Limited | Information & communication | 2012 |
| Safeguard Biosystems Asia Limited | Administrative & support | 2018 |
| Safeguard Biosystems Manufacturing Limited | Administrative & support | 2006 |
| Sagatheow Press Limited | Information & communication | 2024 |
| Salon AI Ltd | Information & communication | 2025 |
| Salon Mentor Limited | Professional & scientific | 2019 |
| Salon Sharesies Ltd | Information & communication | 2025 |
| SAM Rees Jones Limited | Information & communication | 2014 |
| Sands Music Limited | Arts & recreation | 1985 |
| Sandstone Property Limited | Real estate | 2018 |
| Sapphire Stays Management Ltd | Real estate | 2026 |
| Sarah Bryan Design Ltd | Manufacturing | 2023 |
| Sargeant Architects Limited | Professional & scientific | 2015 |
| SAS Fabrications Ltd | Manufacturing | 2004 |
| Satarah Recruitment Ltd | Administrative & support | 2011 |
| Saul Thomas Limited | Construction | 2016 |
| Savages Salon Ltd | Other services | 2021 |
| Savvy Mccash Affiliates Ltd | Wholesale & retail | 2021 |
| Sba-Spi Limited | Professional & scientific | 2025 |
| Sbnc Ltd | Information & communication | 2015 |
| Sc&Cbk Ltd | Wholesale & retail | 2025 |
| Scalehand Limited | Manufacturing | 1978 |
| Scarsdale Grange LLP | | 2011 |
| Scarsdale Grange Nursing Home Limited | Health & social care | 2019 |
| School Hill Barns Ltd | Construction | 2025 |
| School Warehouse Limited | Administrative & support | 1999 |
| Sciascia Ltd | Hospitality | 2017 |
| Scorpion Consultancy Limited | Wholesale & retail | 2016 |
| Scott Dunn Consulting Ltd | Administrative & support | 2023 |
| Scottbridge Limited | Households | 2014 |
| Scotto-Di-Perta Limited | Wholesale & retail | 1983 |
| Screamin' Jack Ltd | Real estate | 2018 |
| SD Holland Limited | Wholesale & retail | 2023 |
| Searlaid Ltd | Real estate | 2022 |
| Securex Investments Limited | Real estate | 2016 |
| Selborne James Ltd | Financial services | 2019 |
| Sencerity Ltd | Administrative & support | 2025 |
| Sense Makers Group Ltd | Education | 2025 |
| Sense of FUN Ltd. | Wholesale & retail | 1992 |
| Senslite Limited | Wholesale & retail | 2020 |
| Sensonics Holdings Limited | Financial services | 2001 |
| Seraphim Investments Limited | Construction | 2025 |
| Service Monitor Limited | Professional & scientific | 2001 |
| SEVEN0707 Ltd | Professional & scientific | 2024 |
| SFS Construction Ltd | Construction | 2015 |
| Sgdirectsourcing Ltd | Professional & scientific | 2020 |
| SH Coaching Services Limited | Other services | 2012 |
| SH Supply Chain Solutions Limited | Professional & scientific | 2020 |
| Shamara (Property) Ltd | Real estate | 2020 |
| Sharp-Ax Computer Systems Limited | Wholesale & retail | 2015 |
| Shaun & Claire's Clean Machine Limited | Administrative & support | 2024 |
| Shaun Oliver Ltd | Wholesale & retail | 2026 |
| Sheena Maccormack Limited | Professional & scientific | 2021 |
| Sherratt Consultancy Limited | Professional & scientific | 2012 |
| SHH Associates Ltd | Information & communication | 2014 |
| SHH Group Ltd | Real estate | 2021 |
| Shivraj Holdings Ltd | Financial services | 2024 |
| Shmbp Limited | Other services | 2021 |
| Shooters Way Securities 2 Limited | Construction | 2025 |
| Shooters Way Securities Limited | Administrative & support | 2025 |
| Shutterlove UK Ltd | Professional & scientific | 2013 |
| Significance Consulting Limited | Professional & scientific | 2023 |
| Silverdale Contracts Ltd | Construction | 2023 |
| Silverdale UK Estates Ltd | Real estate | 2021 |
| Silverthwaite Investment Company Limited | Financial services | 2013 |
| Simeon Innocent Psychiatry Ltd | Health & social care | 2025 |
| Simon James Independent Financial Advisers LLP | | 2022 |
| Simon Lawson Consulting Limited | Professional & scientific | 2007 |
| Simon Sharp Music Limited | Education | 2012 |
| Simply Escapes Ltd | Administrative & support | 2016 |
| Simra Estates Ltd | Real estate | 2016 |
| Simra FDL Ltd | Real estate | 2024 |
| Simra SW1 Ltd | Real estate | 2025 |
| Singularity Search Ltd | Administrative & support | 2026 |
| Sirius Jewellers Ltd | Manufacturing | 2020 |
| Sixtyseven Design Limited | Arts & recreation | 2006 |
| SJ Financial Ltd | Financial services | 2022 |
| SJM 360 Holdings Limited | Real estate | 2021 |
| SK Realties Ltd | Real estate | 2023 |
| SKD Enterprises Ltd | Professional & scientific | 2020 |