| DE Germigney Ltd | Professional & scientific | 2024 |
| DE Salis Consulting Limited | Construction | 2020 |
| Dean Naylor & Sons Painting Ltd | Construction | 2018 |
| Deer Property Developments Ltd | Real estate | 2025 |
| Dekrod Limited | Water & waste | 2000 |
| Deluxe Window Cleaning Limited | Administrative & support | 2016 |
| Denby Hall Central Services Limited | Real estate | 2023 |
| Denby Hall Unit 1 Limited | Real estate | 2023 |
| Denby Hall Unit 2 Limited | Real estate | 2023 |
| Denby Hall Unit 3 Limited | Real estate | 2023 |
| Denby Maintenance Ltd | Construction | 2023 |
| Derby Aggregates and Recycling Limited | Water & waste | 2018 |
| Derby Crushing and Screening Ltd | Water & waste | 2010 |
| Derby Electrical & Maintenance Services Ltd | Construction | 2025 |
| Derby Jazz | Arts & recreation | 2003 |
| Derby Motorbike Training Ltd | Administrative & support | 2016 |
| Derby Property Ltd | Real estate | 2022 |
| Derby Road and Race Limited | Manufacturing | 2003 |
| Derby Servicesure Autocentre Limited | Wholesale & retail | 2014 |
| Derbyshire Air Conditioning Ltd | Energy | 2025 |
| Derbyshire Archery Club | Arts & recreation | 2017 |
| Derbyshire Austins Limited | Professional & scientific | 2017 |
| Derbyshire Biohazard Services Ltd | Administrative & support | 2023 |
| Derbyshire Catering Limited | Hospitality | 2010 |
| Derbyshire Community Foundation | Public administration | 1994 |
| Derbyshire Construction Ltd | Construction | 2022 |
| Derbyshire Domestic Services Ltd | Administrative & support | 2021 |
| Derbyshire Elite Construction Ltd | Construction | 2024 |
| Derbyshire Holidays Limited | Real estate | 2000 |
| Derbyshire Investments (UK) Limited | Construction | 2006 |
| Derbyshire IUK Holdings Limited | Financial services | 2015 |
| Derbyshire Maid Cleaning Services Ltd | Administrative & support | 2025 |
| Derbyshire News Limited | Professional & scientific | 2025 |
| Derbyshire Operational Support Limited | Administrative & support | 2023 |
| Derbyshire Property Trust Limited (the) | Real estate | 1935 |
| Derbyshire Residential Investments Limited | Real estate | 2018 |
| Derbyshire Tea Limited | Hospitality | 2021 |
| Derbyshire Technology Systems Ltd | Information & communication | 2001 |
| Derbyshire Vehicle Repair Centre Ltd | Wholesale & retail | 2020 |
| Derbyshire Wealth Management Ltd | Financial services | 2019 |
| Derventio Childcare Ltd | Health & social care | 2026 |
| Derventio Consulting Limited | Information & communication | 2015 |
| Derventio Energy Limited | Construction | 1995 |
| Derventio Energy Solutions Ltd | Construction | 2013 |
| Derventio Property Limited | Real estate | 2018 |
| Derventio Software Consulting Limited | Information & communication | 2023 |
| Derwent Bookkeeping & Office Services Ltd | Professional & scientific | 2010 |
| Derwent Capital Investment Limited | Financial services | 2021 |
| Derwent Garage Conversions Ltd | Construction | 2024 |
| Derwent Hydro Developments Limited | Agriculture & fishing | 2003 |
| Derwent Investments Ltd | Real estate | 2014 |
| Derwent Technology Limited | Information & communication | 2025 |
| Derwent Therapy Ltd | Health & social care | 2025 |
| Derwent Vale Limited | Real estate | 2026 |
| Derwent Valley Construction Limited | Construction | 1973 |
| Derwent View Management Company Limited | Real estate | 2011 |
| Design & Detailing Xperts Ltd | Construction | 2025 |
| Design & Source Direct Limited | Wholesale & retail | 1999 |
| Dessertalicious Ltd | Other services | 2018 |
| Destination Derbyshire CIC | Arts & recreation | 2026 |
| Destiny Energy Limited | Mining & quarrying | 2015 |
| Developing Minds Psychological Services Ltd | Health & social care | 2009 |
| Devos Prestige Ltd | Wholesale & retail | 2026 |
| Dewsound Limited | Construction | 1997 |
| Dexter Management (Derby) Limited | Professional & scientific | 2004 |
| Dexter Properties Limited | Real estate | 2003 |
| DG4BUILD Ltd | Construction | 2017 |
| Dgerring Education Ltd | Education | 2021 |
| DH Brownlee Limited | Arts & recreation | 2017 |
| DHT Software Consulting Ltd | Information & communication | 2021 |
| DHT Solutions Ltd | Information & communication | 2014 |
| Dice and Barrel Ltd | Hospitality | 2025 |
| Dickie Designs Ltd | Professional & scientific | 2026 |
| Diginew Limited | Construction | 1995 |
| Digsbylets.Com Ltd | Real estate | 2006 |
| Direct Beers Limited | Wholesale & retail | 2005 |
| Director Services Limited | Extraterritorial | 2001 |
| Discovery 24 Ltd | Transport & logistics | 2024 |
| Distinct Gaming Limited | Wholesale & retail | 2017 |
| DIV Consultants Ltd | Information & communication | 2018 |
| DJ Oak Porches Ltd | Manufacturing | 2026 |
| DJB Care Services Limited | Health & social care | 2023 |
| DJG Consulting (Derbyshire) Ltd | Professional & scientific | 2023 |
| DJP Electrical Installations Ltd | Construction | 2015 |
| DKC Property Development Ltd | Construction | 2020 |
| Dkmy Architects Ltd | Professional & scientific | 2013 |
| DLW Company Formation Services 0010 Limited | Extraterritorial | 2013 |
| DLW Company Formation Services 0012 Limited | Extraterritorial | 2013 |
| DLW Company Formation Services 0018 Limited | Extraterritorial | 2013 |
| DLW Company Formation Services 0032 Limited | Extraterritorial | 2013 |
| DLW Company Formation Services 0036 Limited | Extraterritorial | 2013 |
| DML Training Ltd | Transport & logistics | 2022 |
| Dobby Tattoos Ltd | Arts & recreation | 2024 |
| Doodle and Moo's Play Village Ltd | Hospitality | 2025 |
| Dopson Property Limited | Real estate | 2025 |
| Dormouse Books CIC | Wholesale & retail | 2022 |
| DOT COE Limited | Professional & scientific | 2012 |
| DP Drainage Ltd | Water & waste | 2020 |
| DR N RAJ Limited | Health & social care | 2022 |
| DR Philip Mcaleese Ltd | Health & social care | 2018 |