| Refined Studio Limited | Other services | 2025 |
| Regent Finishes Plastering Limited | Construction | 2023 |
| Reggian Properties Ltd | Real estate | 2023 |
| Reggis Limited | Real estate | 2022 |
| Relytca Ltd | Information & communication | 2025 |
| Respond Medical Services Limited | Construction | 2020 |
| Restore & Align Limited | Health & social care | 2026 |
| Retro Revive Parts Ltd | Manufacturing | 2024 |
| RG (Midland) Services Limited | Construction | 2022 |
| RIA Pizza Ltd | Hospitality | 2026 |
| Rice Rice Baby Ltd | Hospitality | 2023 |
| Richard Townsend Ltd | Wholesale & retail | 2015 |
| Right Estate Commercial Limited | Real estate | 2016 |
| Ripple SEO Limited | Professional & scientific | 2020 |
| RJM Automation Limited | Information & communication | 2014 |
| RJM Transport Consultancy Ltd | Professional & scientific | 2023 |
| RLD Construction Services Limited | Professional & scientific | 2022 |
| Roadstar Automobile Ltd | Wholesale & retail | 2016 |
| Robust Care Solutions Ltd | Health & social care | 2016 |
| Rolamtech Limited | Information & communication | 1999 |
| Roman Aston Developments Limited | Construction | 2018 |
| Roots and Roofs Ltd | Real estate | 2025 |
| Roseric Medical Services Ltd | Health & social care | 2011 |
| RPS Mechanical Services Limited | Construction | 2003 |
| RRM Logistics Ltd | Transport & logistics | 2024 |
| RS Electrical Warks Limited | Construction | 2024 |
| RSM Industries Limited | Manufacturing | 1985 |
| RSP Brickwork Ltd | Construction | 2023 |
| Rubix Property Repair Ltd | Construction | 2020 |
| Rugby 44 Limited | Other services | 2018 |
| Ruse Motors Ltd | Wholesale & retail | 2021 |
| Rushways Ltd | Health & social care | 2014 |
| Ryton Partners Ltd | Transport & logistics | 2012 |
| S and J Electrical Leicester Ltd | Construction | 2024 |
| S J Piekarz Limited | Transport & logistics | 2013 |
| S J Solutions Group Limited | Professional & scientific | 2015 |
| S Jack Supplies Ltd | Wholesale & retail | 2010 |
| S W Pearson Engineering Services Limited | Professional & scientific | 2002 |
| S&A Housing Management Limited | Real estate | 2023 |
| Saber Fitness Limited | Wholesale & retail | 2017 |
| Saber Flooring Ltd | Wholesale & retail | 2020 |
| SAF FM Limited | Administrative & support | 2015 |
| Safe Space Counselling CIC | Health & social care | 2025 |
| Safety 1ST for Sport Ltd | Arts & recreation | 2024 |
| Saffron Tandoori Spice Ltd | Hospitality | 2015 |
| SAI LOI Investments Ltd | Real estate | 2015 |
| Salim Fitness Ltd | Arts & recreation | 2020 |
| Salim Personal Training Limited | Arts & recreation | 2020 |
| SAM GRP Ltd | Administrative & support | 2018 |
| Sameday 365 Ltd | Transport & logistics | 2016 |
| Sapnav Consultancy Ltd | Information & communication | 2024 |
| Sapori Victoria Limited | Hospitality | 2019 |
| Satty Thandi Limited | Hospitality | 2019 |
| Saturn Magic Limited | Wholesale & retail | 2016 |
| Scdx Management UK Ltd | Hospitality | 2024 |
| School Run Ride Ltd | Transport & logistics | 2025 |
| SCHOOLRIDE4U Ltd | Transport & logistics | 2025 |
| Scorp Investments Limited | Real estate | 2022 |
| Sea Isle Limited | Wholesale & retail | 1986 |
| SEC Consult Ltd | Administrative & support | 2026 |
| Secret Gardens Management Limited | Real estate | 2017 |
| Secure a Key Ltd | Administrative & support | 2025 |
| Seesaw Nursery Baby and Toddler Limited | Health & social care | 2024 |
| Selfie Photo Booth Limited | Professional & scientific | 2023 |
| Senior Surfer Ltd | Professional & scientific | 2024 |
| Sethi Estates PVT Ltd | Real estate | 2025 |
| Seven Sisters Functional Limited | Arts & recreation | 2018 |
| Severn Estates | | 1995 |
| Sgate Engineering Group Limited | Manufacturing | 2023 |
| Shabeth Heath Ltd | Health & social care | 2016 |
| Shabeth Property Ltd | Real estate | 2020 |
| Shaddess Ltd | Health & social care | 2025 |
| Shannon Nickols Ltd | Transport & logistics | 2025 |
| Shapes Day Nursery Limited | Education | 2011 |
| Shaw Care Bedworth Ltd | Health & social care | 2025 |
| Shawify Ltd | Wholesale & retail | 2026 |
| Shenstone House Day Nurseries Limited | Education | 1989 |
| Shepherding Consulting Ltd | Administrative & support | 2017 |
| Shepherdit QA Ltd | Information & communication | 2023 |
| Shopmagic Ltd | Wholesale & retail | 2024 |
| Shummi Ltd | Hospitality | 2020 |
| Shyama Enterprises Limited | Real estate | 2022 |
| Sideland Property Holdings Limited | Construction | 2017 |
| Silver Heritage Ltd | Extraterritorial | 2022 |
| Simply Doughlicious Ltd | Hospitality | 2026 |
| Simply Local (Bedworth) Ltd | Wholesale & retail | 2014 |
| Simsania Ltd | Wholesale & retail | 2022 |
| Singapore Garden Limited | Hospitality | 2011 |
| Singhs 1 Properties Limited | Real estate | 2025 |
| Singhs Fisheries Limited | Hospitality | 2020 |
| Sishan Limited | Hospitality | 2015 |
| Sitefinders NET Limited | Information & communication | 1996 |
| SJT Investments Ltd | Real estate | 2019 |
| SJW Dog Training Ltd | Other services | 2026 |
| SK Logistic Services Ltd | Transport & logistics | 2019 |
| Sky Blue Rigging Ltd | Construction | 2018 |
| Skyblue K9 Specialist Ltd | Other services | 2025 |
| Skye IT Consultation Ltd | Professional & scientific | 2025 |
| Soberistas Ltd | Health & social care | 2013 |
| Social Work Assessment Partners Ltd | Health & social care | 2005 |