| PH and D Housing Ltd | Real estate | 2026 |
| PH Construction (NE) Ltd | Construction | 2023 |
| Phoenix Future Projects Ltd | Professional & scientific | 2025 |
| Phoenix Media and Publishing Ltd | Extraterritorial | 2019 |
| Pigeon & Whippet (Ashington) Limited | Hospitality | 2023 |
| PK Douglas Building & Roofing Services Limited | Construction | 2012 |
| Plant-Tech NE Limited | Administrative & support | 2018 |
| Platform Trading Ltd | Arts & recreation | 2015 |
| Pluribus Consulting Ltd | Information & communication | 2021 |
| Prairie Studio Ltd | Professional & scientific | 2022 |
| Premier Plant & Civil Engineering (UK) Limited | Construction | 2013 |
| Premier Plant Holding Company (UK) Limited | Financial services | 2023 |
| Premier Plant Surfacing (UK) Limited | Construction | 2018 |
| Primary Enterprise World (North East) Limited | Administrative & support | 2017 |
| Prizim Engineering Ltd | Professional & scientific | 2021 |
| Properties by M&M Ltd | Real estate | 2022 |
| Public Sector Projects Limited | Professional & scientific | 2024 |
| Pubs and Hotels Ltd | Hospitality | 2025 |
| Q BEE Ltd | Extraterritorial | 2019 |
| R Binks Limited | Wholesale & retail | 1990 |
| R E Consultancy Services (North East) Limited | Professional & scientific | 2022 |
| R Laws Mechanical Solutions Ltd | Construction | 2023 |
| Rae's MOT & Service Centre Ltd | Wholesale & retail | 2018 |
| Rafaelo Limited | Hospitality | 2016 |
| RAR Property Services Limited | Construction | 2010 |
| Rawtm Limited | Construction | 2022 |
| RB Blackburn Ltd | Construction | 2015 |
| RBB Group Ltd | Construction | 2017 |
| Red Umbrella Ltd | Professional & scientific | 2021 |
| Redress Limited | Health & social care | 1997 |
| Refine Home Improvement Specialists Ltd | Construction | 2024 |
| Rejm Welding Services Limited | Construction | 2026 |
| Remondis Limited | Water & waste | 2003 |
| Remondis Waste Solutions Limited | Administrative & support | 1992 |
| Rentabox Limited | Administrative & support | 2020 |
| Resilets: Blyth Quay Ltd | Real estate | 2023 |
| RF GAS Services Ltd | Construction | 2026 |
| RF Properties NE Ltd | Real estate | 2026 |
| Richardsons Amusements Ltd | Arts & recreation | 2022 |
| Ridge Terrace Allotment Association Community Interest Company | Agriculture & fishing | 2017 |
| RJF Render Systems Limited | Construction | 2015 |
| RJP Transformation Limited | Extraterritorial | 2015 |
| RLR CAD Limited | Professional & scientific | 2024 |
| Robinsonfrench Ltd | Administrative & support | 2026 |
| Rogers Renovations and Rentals Limited | Real estate | 2021 |
| Rokt Construction Limited | Construction | 2025 |
| RON Wylie Consulting Limited | Professional & scientific | 2018 |
| Rossini (Amble) Limited | Extraterritorial | 2018 |
| Rossini (Newcastle) Limited | Extraterritorial | 2016 |
| Rossini (North East) Limited | Extraterritorial | 2016 |
| Route Connections Ltd | Other services | 2022 |
| Royle Plumbing & Heating Ltd | Construction | 2025 |
| RSA Tech Ltd | Professional & scientific | 2023 |
| RWL Firestopping Limited | Public administration | 2022 |
| S D V Joshua Ltd | Wholesale & retail | 2024 |
| S G Cabling Limited | Construction | 2011 |
| S G Traffic Management Limited | Construction | 2021 |
| S J S Traffic Management Limited | Extraterritorial | 2016 |
| Safin Property Ltd | Real estate | 2021 |
| SB Hills Limited | Construction | 2015 |
| Sbamznfba Limited | Wholesale & retail | 2023 |
| Sbne Installations Ltd | Construction | 2025 |
| Scmetcalfe Ltd | Energy | 2019 |
| Scott Dowden TR Limited | Information & communication | 2014 |
| Scrub Hub Cleaning Services Limited | Administrative & support | 2025 |
| Sea & Soul (Amble) Limited | Hospitality | 2025 |
| Second Wind Services Ltd | Manufacturing | 2025 |
| Sector Specific Training and Consultancy Ltd | Education | 2018 |
| Securefast Northeast Ltd | Construction | 2019 |
| Self Help Start UP Limited | Health & social care | 2012 |
| Services MT Ltd | Wholesale & retail | 2025 |
| SHE Assist Limited | Administrative & support | 2015 |
| Sheqc Limited | Professional & scientific | 2022 |
| Shivdhya Ltd | Hospitality | 2019 |
| Shrpi Solutions Limited | Information & communication | 2016 |
| SJ & Z Property Ltd | Real estate | 2024 |
| SJ Access Ltd | Construction | 2017 |
| Skye Olivia Aesthetics Ltd | Other services | 2024 |
| Skyserve Limited | Professional & scientific | 2011 |
| Sleekburn Estates Limited | Construction | 1983 |
| SLS Commercials Limited | Wholesale & retail | 2013 |
| SLS Management Limited | Real estate | 2018 |
| SM Building Services (NE) Ltd | Construction | 2022 |
| SMT Building and Landscaping Limited | Construction | 2020 |
| Soleil Botanique Ltd | Wholesale & retail | 2026 |
| Solon Holdings Ltd | Professional & scientific | 2024 |
| Solon Litigation Solutions Ltd | Extraterritorial | 2023 |
| Solon SPC NO1 Ltd | Professional & scientific | 2024 |
| Sound People Limited | Information & communication | 2023 |
| South East Northumberland Recycling Limited | Water & waste | 1999 |
| Spa Legal Services Ltd | Professional & scientific | 2025 |
| Spicy Brain Energy Ltd | Administrative & support | 2023 |
| Splash Bathrooms NE Ltd | Construction | 2021 |
| Spotty Dog Daycare Ltd | Agriculture & fishing | 2022 |
| Srbell Mechanical Engineering Ltd | Professional & scientific | 2024 |
| Stage Right Promotions Limited | Arts & recreation | 2006 |
| Starling Property Group Ltd | Households | 2025 |
| Station Entertainments Limited | Information & communication | 2011 |
| Statnova Ltd | Professional & scientific | 2025 |
| Stephanie Ward & Co Limited | Administrative & support | 2026 |