| Decant Limited | Other services | 2018 |
| Decent Cars Ltd | Wholesale & retail | 2022 |
| Decent Homes Consultants Ltd | Administrative & support | 2010 |
| Decimal Primary Care Ltd | Health & social care | 2026 |
| Decimal Properties Limited | Real estate | 2020 |
| Decimal Technologies Ltd | Construction | 2014 |
| Declaration Software Ltd | Information & communication | 2019 |
| Declutter Training Limited | Other services | 2026 |
| Declutter With Delight Limited | Administrative & support | 2024 |
| Deco & DO Ltd | Administrative & support | 2023 |
| DEE BEE Trading Ltd | Wholesale & retail | 2025 |
| Deebeetom Ventures Ltd | Wholesale & retail | 2021 |
| Deedor Company Limited | Other services | 2007 |
| Deefor Design Limited | Professional & scientific | 2006 |
| Deep Play Digital Limited | Information & communication | 2025 |
| Deep Soil Mixing Ltd | Construction | 2012 |
| Deep Soil Mixing Technical Services Ltd | Construction | 2016 |
| Deepani Traders Limited | Hospitality | 2022 |
| Deepblue Aquatic Limited | Wholesale & retail | 2009 |
| Deeper Context Limited | Education | 2025 |
| Defence Logistics Ltd | Manufacturing | 2014 |
| Defenza Ltd | Information & communication | 2024 |
| Defeo Builders Ltd | Construction | 2025 |
| Defeo Developments Ltd | Real estate | 2025 |
| Define Care Services Ltd | Health & social care | 2024 |
| Defne SON Ltd | Other services | 2019 |
| DEI Gratia Services Ltd | Health & social care | 2023 |
| Deified Limited | Real estate | 1973 |
| Deja Brew Coffee Box Ltd | Hospitality | 2024 |
| Deka Holdings Ltd | Administrative & support | 2016 |
| Deka Motors Ltd | Wholesale & retail | 2023 |
| Delafinn Global Limited | Professional & scientific | 2018 |
| Delaine Properties Ltd | Real estate | 2024 |
| Delego Supermarket Ltd | Wholesale & retail | 2024 |
| Delever Limited | Professional & scientific | 2001 |
| Delfina Ventures Ltd | Real estate | 2024 |
| Delisha Foods Limited | Hospitality | 2012 |
| Delite Media Limited | Professional & scientific | 2018 |
| Deliver Sovereignty Ltd. | Transport & logistics | 2018 |
| Della Judd Limited | Professional & scientific | 2019 |
| Delsaro Ltd | Professional & scientific | 2013 |
| Delsaro Scientific Solutions Limited | Professional & scientific | 2013 |
| Delta Mart Limited | Wholesale & retail | 2015 |
| Delta Stone Limited | Other services | 2018 |
| Deltaline Design Limited | Construction | 2009 |
| Delto Consulting Ltd | Professional & scientific | 2022 |
| Delxpress Limited | Transport & logistics | 2007 |
| Demaax Ltd | Professional & scientific | 2012 |
| Demand Express Limited | Transport & logistics | 2025 |
| Demeterca Ltd | Administrative & support | 2018 |
| Demi Leigh Aesthetic Clinic Limited | Other services | 2026 |
| Demir’S Group Limited | Construction | 2024 |
| Dena Plant Limited | Administrative & support | 2008 |
| Dench Psychology Ltd | Education | 2026 |
| Denchevi Ltd | Construction | 2025 |
| Denedy Ltd | Construction | 2017 |
| Denham Autos Ltd | Wholesale & retail | 2025 |
| Denham Properties Limited | Real estate | 2021 |
| Denis Class 1 Ltd | Transport & logistics | 2022 |
| Denis Fish Bar Ltd | Hospitality | 2025 |
| Denisa Limited | Transport & logistics | 2025 |
| Denmanair Limited | Construction | 1999 |
| Denmark Street Fish & Chip Shop (Bedford) Ltd | Hospitality | 2020 |
| Dennis-Beddall Ltd | Wholesale & retail | 2019 |
| Denrose Limited | Real estate | 2016 |
| Dent Bustas Limited | Wholesale & retail | 2003 |
| Dental Tree Group Limited | Health & social care | 2013 |
| Dentcare Dental LAB UK Ltd | Health & social care | 2017 |
| Dentpractice Ltd | Health & social care | 2025 |
| Denturetech Laboratory Limited | Manufacturing | 2016 |
| Denwen Ltd | Wholesale & retail | 2020 |
| DEO Gratias Immigration Solutions Ltd | Professional & scientific | 2026 |
| Dept 123 Ltd | Construction | 2020 |
| Derbygreen Limited | | 1978 |
| Derek Holden Properties Limited | Real estate | 2005 |
| Derellz Limited | Construction | 2026 |
| Derma by Paige Ltd | Other services | 2019 |
| Dermacode Limited | Manufacturing | 2023 |
| Dermalexis Limited | Wholesale & retail | 2025 |
| Dermme Health Limited | Health & social care | 2025 |
| Deryck Tremble Limited | Extraterritorial | 2022 |
| Desi Darbaar Limited | Hospitality | 2025 |
| Design & Draughting Solutions Limited | Professional & scientific | 2004 |
| Design Factory of Chiswick Limited | Other services | 2008 |
| Design Finishing Holdings Ltd | Financial services | 2021 |
| Design Line Flooring Limited | Construction | 2002 |
| Design Mats Limited | Extraterritorial | 1984 |
| Design Particles Ltd | Manufacturing | 2023 |
| Design Plan Build Services Ltd | Professional & scientific | 2022 |
| Design Source Engineering Solutions Limited | Professional & scientific | 2015 |
| Design+Plan Limited | Professional & scientific | 2013 |
| Design-Pile-Construct Ltd | Construction | 2022 |
| DESIGN92 Limited | Professional & scientific | 2019 |
| Designdocs Limited | Professional & scientific | 2025 |
| Designs ETC Limited | Arts & recreation | 2025 |
| Desirabullz Ltd. | Other services | 2017 |
| Desirol Limited | Health & social care | 2023 |
| Dessert Island Heaven Ltd | Hospitality | 2024 |
| Dessertsandbreakfast Ltd | Hospitality | 2025 |
| Destination Training Group Limited | Arts & recreation | 2024 |