| Sovereign Real Estate Ltd | Real estate | 2025 |
| Sovereigns Quay (42-70) RTM Company Limited | Households | 2020 |
| Sovereigns Quay (71-107) RTM Company Limited | Households | 2020 |
| Soxna Momy Ltd | Transport & logistics | 2025 |
| Soza Health Limited | Health & social care | 2014 |
| SP Construction Services Ltd | Professional & scientific | 2008 |
| SP Elite Group Ltd | Real estate | 2026 |
| SP Legal Consulting Limited | Professional & scientific | 2023 |
| SP Samarth Consultant Limited | Transport & logistics | 2026 |
| Spaacis Limited | Information & communication | 2018 |
| Space Fuel Ltd | Manufacturing | 2023 |
| Space Jackets Ltd | Professional & scientific | 2017 |
| Space Measured Limited | Construction | 2016 |
| Space Resources Laboratory Ltd | Manufacturing | 2019 |
| Spacepack Limited | Extraterritorial | 1982 |
| Spaghetti Mafia Limited | Wholesale & retail | 2023 |
| Spagotsp Limited | Construction | 2025 |
| Sparkle (Cardiff) Ltd | Real estate | 2020 |
| Sparkles & Shine Cleaning Limited | Administrative & support | 2022 |
| Sparks & Green Ltd | Professional & scientific | 2017 |
| Sparkwell Holdings Limited | Real estate | 2023 |
| Sparky Resolutions Limited | Manufacturing | 2021 |
| Sparrow Beds Ltd | Administrative & support | 2022 |
| Sparrow Accounting Limited | Professional & scientific | 2014 |
| Sparrow Car Detailing Ltd | Wholesale & retail | 2026 |
| Spatha Strategic Solutions Ltd | Professional & scientific | 2022 |
| Spavins Contract Services Limited | Administrative & support | 2014 |
| SPD Development Company Limited | Professional & scientific | 2006 |
| Spec Partners Ltd | Professional & scientific | 2009 |
| Special and Co. Ltd | Health & social care | 2019 |
| Specialist Business Consultants Limited | Construction | 1993 |
| Specialist Logistics Services Limited | Transport & logistics | 2016 |
| Specialist Microwave Solutions Limited | Manufacturing | 1999 |
| Specialist Power Systems Limited | Construction | 2002 |
| Specialized Skateboards Ltd | Wholesale & retail | 2020 |
| Specsonweb Ltd | Wholesale & retail | 2020 |
| Spectacularts CIC | Arts & recreation | 2018 |
| Spectra Accounting Services Ltd | Professional & scientific | 2025 |
| Spectraforge Audio Ltd | Information & communication | 2026 |
| Spectronic Devices Limited | Manufacturing | 1999 |
| Spectrum Car Scheme Management Ltd | Administrative & support | 1997 |
| Spectrum Efficient Energy Ltd | Manufacturing | 2011 |
| Spectrum Enamellers Limited | Manufacturing | 2001 |
| Spectrum Halal Foods Ltd | Wholesale & retail | 2020 |
| Speechpath Limited | Information & communication | 2011 |
| Speed Line 247 Logistics Ltd | Other services | 2019 |
| Speedforce Limited | Construction | 2004 |
| Speedy Parts Group Ltd | Wholesale & retail | 2019 |
| Speeg Car and Van Ltd | Wholesale & retail | 2024 |
| Speeg Van Security Ltd | Extraterritorial | 2024 |
| Spencer Associates International Limited | Administrative & support | 2017 |
| Spenser Road Maintenance Company Limited | Other services | 1988 |
| Spenser Sales Limited | Wholesale & retail | 2025 |
| Spey Finance Limited | Financial services | 2016 |
| SPG 26 Ltd | Real estate | 2018 |
| Sphinx Solutions Consultancy Ltd | Information & communication | 2026 |
| SPI Consultants UK Limited | Administrative & support | 2001 |
| Spice Box Bedford Ltd | Hospitality | 2026 |
| Spice Flitwick Limited | Hospitality | 2020 |
| Spice of Bedford Limited | Hospitality | 2022 |
| Spice United Ltd | Wholesale & retail | 2020 |
| SPICEHOUSE49 Ltd | Hospitality | 2016 |
| Spicer Holdings Ltd | Manufacturing | 2020 |
| Spinifex Accounting Services Limited | Professional & scientific | 2012 |
| Spiral Freerun CIC | Wholesale & retail | 2021 |
| Spirited Intent Ltd | Wholesale & retail | 2022 |
| SPK Contracting & Management Services Limited | Construction | 2015 |
| Splash Music Limited | Arts & recreation | 2019 |
| Splash Pads Enterprises Limited | Construction | 2001 |
| Splc Training Ltd | Professional & scientific | 2026 |
| Spoilme Nail Supply Ltd | Wholesale & retail | 2021 |
| Sponza Ltd | Information & communication | 2025 |
| Spool & Bobbin Ltd | Other services | 2019 |
| Sport for Bedford Limited | Arts & recreation | 1993 |
| Sporting AID CIC | Arts & recreation | 2023 |
| Sporting Bears Motor Club Limited | Other services | 2016 |
| Sports Link Group Ltd | Arts & recreation | 2015 |
| Sports Massage Bedford Ltd | Arts & recreation | 2015 |
| Spotless Pro Cleaning Services Ltd | Administrative & support | 2024 |
| Spotless Solutions Cleaning Ltd | Administrative & support | 2026 |
| Spowan Partners LLP | | 2024 |
| SPQ Retail Limited | Information & communication | 2014 |
| Spray Kitchen Station Limited | Construction | 2025 |
| Spray Shield Limited | Other services | 2019 |
| Sprayclad UK Limited | Construction | 2018 |
| Sprd Arts Ltd | Construction | 2025 |
| Spring Plumbing & Heating Ltd | Construction | 2014 |
| Springdom Ltd | Hospitality | 2024 |
| Springdon Court Residents Association Limited | Administrative & support | 1985 |
| Springfield Business Supplies Limited | Wholesale & retail | 1998 |
| Springful Ltd | Education | 2025 |
| Springhill Associates Ltd | Professional & scientific | 2012 |
| Springhill Farms Limited | Agriculture & fishing | 1989 |
| Springwell Investments Limited | Professional & scientific | 2003 |
| Springwood Publishing Limited | Arts & recreation | 2020 |
| Sprint With the Stars Ltd | Arts & recreation | 2022 |
| Sprite Photography Limited | Professional & scientific | 2015 |
| Spruce Consulting Limited | Professional & scientific | 2021 |
| SPS Cooling Solutions Ltd | Construction | 2023 |
| Spud Army Ltd | Hospitality | 2025 |