| Shalom Housing CIC | Real estate | 2024 |
| Shammah Capital Limited | Households | 2020 |
| Shampoochd Ltd | Other services | 2026 |
| Shancharan Limited | Wholesale & retail | 2014 |
| Shanevanbeek Limited | Information & communication | 2014 |
| Shankrs Ltd | Arts & recreation | 2026 |
| Sharai Ltd | Health & social care | 2026 |
| Sharan Chohan Limited | Professional & scientific | 2022 |
| Sharang Limited | Transport & logistics | 2026 |
| Sharath E-Solutions Limited | Information & communication | 2016 |
| Sharedimpact | Financial services | 2011 |
| Sharedimpact Foundation (UK) Limited | Administrative & support | 2014 |
| Sharedimpact Ventures Ltd | Financial services | 2012 |
| Sharemeadow Residents Association Limited | Households | 1992 |
| Shareprivate Residents Management Limited | Real estate | 1988 |
| Sharnbrook Deli Cafe Ltd | Hospitality | 2024 |
| Sharnbrook News Limited | Wholesale & retail | 2006 |
| Sharpe Travels Ltd | Administrative & support | 2026 |
| Sharpenhoe Change Managers Ltd | Financial services | 2007 |
| Sharpenhoe Management Limited | Water & waste | 1999 |
| Sharper Healthcare Limited | Health & social care | 2014 |
| Shauna&Zara Ltd | Hospitality | 2021 |
| Shawsaloza Limited | Wholesale & retail | 2026 |
| Shawspark Psychotherapy Ltd | Health & social care | 2021 |
| Shaya Industries UK Limited | Manufacturing | 2025 |
| SHC Building Ltd | Construction | 2025 |
| SHC Contractors Ltd | Information & communication | 2026 |
| SHE Leads Consultancy Ltd | Administrative & support | 2024 |
| She's Obsessed Limited | Professional & scientific | 2020 |
| She's Obsessed Property Ltd | Real estate | 2021 |
| Shea Ventures Limited | Information & communication | 2022 |
| Shebang Fire and Security Limited | Administrative & support | 2024 |
| Shebang FM Limited | Administrative & support | 2022 |
| Shebang Security Limited | Administrative & support | 2022 |
| Shed Food Group Ltd | Hospitality | 2022 |
| Shedlance Ltd | Health & social care | 2024 |
| Shedswarehouse Limited | Wholesale & retail | 2011 |
| Sheemma Ltd | Other services | 2025 |
| Shefford Property Holdings Limited | Construction | 2021 |
| Shefford Road Management Limited | Households | 2015 |
| Sheikhoo Limited | Wholesale & retail | 2025 |
| Sheldon Paper Limited | Extraterritorial | 1946 |
| Shellzgadgets Ltd | Manufacturing | 2025 |
| Shelton Carpentry Ltd | Manufacturing | 2024 |
| Shelton Farm Estates Limited | Real estate | 2010 |
| Shelton Farm Management Company (Lower Shelton) Ltd | Households | 2021 |
| Shenley Bay Holdings Limited | Financial services | 2022 |
| Shepherd Stubbs Limited | Administrative & support | 1993 |
| Sherlocks Property Consultants Limited | Financial services | 2014 |
| Sherpa Marketing Limited | Professional & scientific | 2012 |
| Sherpashire Ltd | Administrative & support | 2026 |
| Sheryl Close Ltd | Health & social care | 2012 |
| Shhh Club Ltd | Administrative & support | 2019 |
| Shield Engineering MK Ltd | Manufacturing | 2019 |
| Shield Safety Systems Ltd | Construction | 2015 |
| Shifaau Care Limited | Health & social care | 2015 |
| Shift Events UK Ltd | Administrative & support | 2025 |
| Shift Left QA Ltd | Professional & scientific | 2023 |
| Shift PAY Ltd | Information & communication | 2025 |
| Shiloh House Holdings Ltd | Professional & scientific | 2022 |
| Shimmer and Shine Cleaning Services Ltd | Administrative & support | 2023 |
| Shimmi K9 Security Limited | Administrative & support | 2024 |
| Shine Acrobatic Gymnastics Club Ltd | Education | 2025 |
| Shine BID Services Ltd | Administrative & support | 2013 |
| Shine Learning and Training Centre Beds Ltd | Education | 2023 |
| Shine SA Ltd | Real estate | 2024 |
| Shine.Clean.Pristine Limited | Households | 2008 |
| Shiner Plant Hire Limited | Construction | 2002 |
| Shiny Teefs Ltd | Wholesale & retail | 2024 |
| Ship Cars Limited | Transport & logistics | 2019 |
| Shiparo Limited | Extraterritorial | 2012 |
| Shipping and Trading Company Ltd | Transport & logistics | 2023 |
| Shire Court Management Company (NO.2) Limited | Households | 2005 |
| Shire Estate Management Ltd | Real estate | 2025 |
| Shires Energy Limited | Professional & scientific | 2024 |
| Shirley Holdings Limited | Real estate | 2020 |
| Shivah Ltd | Health & social care | 2025 |
| Shivam Jewellers Limited | Wholesale & retail | 2011 |
| Shloky Enterprises Ltd | Real estate | 2025 |
| Shlusar Wellness Limited | Other services | 2016 |
| Shokd Ltd | Administrative & support | 2018 |
| Shortcuts MC Ltd | Other services | 2016 |
| Shortstown Community Trust | Arts & recreation | 2004 |
| Shoshme Ltd | Wholesale & retail | 2022 |
| Showpiece BI Limited | Information & communication | 2024 |
| Shree Consulting Ltd | Information & communication | 2020 |
| Shree Ganesh Clothing Ltd | Wholesale & retail | 2020 |
| Shree Ghanshyam Limited | Real estate | 2024 |
| Shree Kateel Hospitality Group Limited | Hospitality | 2026 |
| Shree Traders Ltd | Wholesale & retail | 2020 |
| Shree Varni UK Limited | Wholesale & retail | 2025 |
| Shreeji Diagnotics PVT Ltd | Health & social care | 2012 |
| Shreeves Construction Ltd | Construction | 2019 |
| Shrewd Consultants Limited | Information & communication | 2012 |
| Shrewd Goose Limited | Professional & scientific | 2018 |
| Shri Vishwanath Dham, Sanatan Sanskruti Kendra CIC | Other services | 2025 |
| Shriji Pharma Ltd | Information & communication | 2013 |
| Shrishti Private Ltd | Administrative & support | 2022 |
| Shriya Properties Ltd | Real estate | 2020 |
| Shrubbery Farm Limited | Extraterritorial | 2021 |