| Socrates Estates Ltd | Real estate | 2014 |
| SOF Studio Ltd | Professional & scientific | 2023 |
| Sofia MED Limited | Wholesale & retail | 2025 |
| Soft Jadesen Co., Ltd | Extraterritorial | 2015 |
| Softaa Ltd | Information & communication | 2022 |
| Sohao Group Ltd | Manufacturing | 2022 |
| Sohnu Limited | Real estate | 2020 |
| Sokay International Biological Co., Ltd | Extraterritorial | 2020 |
| Sola Trade Limited | Wholesale & retail | 2023 |
| Solar Hero Limited | Manufacturing | 2025 |
| Solar Marine Solutions Ltd | Extraterritorial | 2025 |
| Solar Sail Technoligies UK Ltd | Information & communication | 2023 |
| Solarix Ltd | Information & communication | 2011 |
| Sold.Buy.Simon Ltd | Real estate | 2023 |
| Sole Beauty Salons Limited | Other services | 2015 |
| Soleman Group Co., Ltd | Professional & scientific | 2022 |
| Solitaire Textile Machines Ltd | Manufacturing | 2026 |
| Solo Timber Frame Limited | Construction | 2003 |
| Solus Industrial Company Limited | Extraterritorial | 2008 |
| Solutions Check Limited | Professional & scientific | 2017 |
| Solvax International Ltd | Extraterritorial | 2014 |
| Solway Import&Export Co., Ltd | Extraterritorial | 2015 |
| Somebody & Sons Limited | Administrative & support | 2019 |
| Somkenny Services Limited | Other services | 2025 |
| Somo Trading Company Limited | Extraterritorial | 2020 |
| Sonabot Limited | Information & communication | 2021 |
| Sonas Investments Group Ltd | Administrative & support | 2026 |
| Sonas Partners Ltd | Administrative & support | 2026 |
| Songceng Trade Co., Ltd | Extraterritorial | 2020 |
| Songyu Global Art Consulting Co., Ltd | Extraterritorial | 2019 |
| Songyuan Trading Co., Limited | Extraterritorial | 2017 |
| Sonicforge Ltd | Wholesale & retail | 2024 |
| Sonly Industries Ltd | Manufacturing | 2024 |
| Soonpak Packaging Group Ltd | Manufacturing | 2025 |
| Soria Investments Ltd | Real estate | 2006 |
| Sortie Watches Limited | Wholesale & retail | 2024 |
| Soul Light Candles Limited | Manufacturing | 2026 |
| Soulifelondon Ltd | Wholesale & retail | 2025 |
| Sound Technologies Services Limited | Other services | 2018 |
| Source Co International (UK) Ltd | Wholesale & retail | 2020 |
| Source Network Limited | Manufacturing | 2024 |
| Source One Trading Co., Limited | Wholesale & retail | 2023 |
| Source Pattern Association | Other services | 2020 |
| Sourcing Wise Supply Chain Ltd | Wholesale & retail | 2023 |
| Sousa Cleaning Services (London) Ltd | Administrative & support | 2022 |
| South Africa Alidy Biotechnology Co., Ltd | Mining & quarrying | 2023 |
| South East Living Limited | Extraterritorial | 2003 |
| South Eastern Laundrettes Limited | Other services | 2000 |
| South END Road Developments Ltd | Construction | 2019 |
| South Forest Limited | Wholesale & retail | 2024 |
| South London Locks Ltd | Construction | 2009 |
| South London Rooms Ltd | Real estate | 2018 |
| South of the River Digital Radio Ltd | Information & communication | 2022 |
| Southern Trade International Limited | Manufacturing | 2024 |
| Sovalue Industry Co., Ltd | Extraterritorial | 2018 |
| Sovereign House (Chislehurst) Management Limited | Households | 2002 |
| SOW Pretty Limited | Extraterritorial | 2016 |
| Sowelly Products Limited | Extraterritorial | 2021 |
| Soymed Ltd. | Extraterritorial | 2021 |
| Space Frontier Ltd | Information & communication | 2021 |
| Spadec Limited | Information & communication | 2025 |
| Spain Aiweiya Mining Group Ltd | Extraterritorial | 2023 |
| Spain Beitaer Crop Science Co., Ltd | Extraterritorial | 2024 |
| Spain Daonong Biology Group Ltd | Extraterritorial | 2021 |
| Spain Dawson Plant Nutrition Co., Ltd | Extraterritorial | 2022 |
| Spain Firter Plant Nutrition Technology Co., Ltd. | Manufacturing | 2025 |
| Spain Fuleshi Ltd | Extraterritorial | 2024 |
| Spain Gabor Science Co., Ltd | Manufacturing | 2024 |
| Spain Gelaite International Holding Ltd | Extraterritorial | 2024 |
| Spain Porgia Biochemical Co., Ltd | Mining & quarrying | 2023 |
| Sparkworks Coaching Ltd | Professional & scientific | 2024 |
| Sparsh Limited | Health & social care | 2013 |
| Spay Group China Import and Export Limited | Extraterritorial | 2016 |
| SPD Estate Consultancy Ltd | Construction | 2008 |
| Specialised Ophthalmic Services Ltd | Wholesale & retail | 2023 |
| Specialist Consultancy Management Limited | Professional & scientific | 2017 |
| Specialist Operations Security Limited | Administrative & support | 2025 |
| Spectacular Nails Ltd | Other services | 2024 |
| SPG Site Investigation Ltd | Professional & scientific | 2021 |
| Spilote Co., Limited | Manufacturing | 2023 |
| Spiresync Ltd | Wholesale & retail | 2025 |
| Spotlites Theatre Productions Limited | Extraterritorial | 2004 |
| Spotright Ltd | Administrative & support | 2023 |
| Spring Holding Co., Ltd | Extraterritorial | 2019 |
| Spring Tools Industrial Ltd | Wholesale & retail | 2022 |
| Springfield Partners Limited | Information & communication | 2005 |
| Springform Limited | Real estate | 2013 |
| Sprint Consultants Limited | Information & communication | 2011 |
| SPS Heating Building Services Limited | Construction | 2007 |
| Spuddz Ltd | Arts & recreation | 2019 |
| SPY Cellar Ltd | Wholesale & retail | 2024 |
| SQ Music Group Ltd | Wholesale & retail | 2023 |
| Square Private Markets Limited | Financial services | 2018 |
| Square the Circle INV Limited | Real estate | 2023 |
| Srai Design Limited | Professional & scientific | 2019 |
| SRC Engineering Systems Limited | Administrative & support | 2007 |
| SRG Bearings Ltd | Manufacturing | 2025 |
| SS Chicken Private Ltd | Hospitality | 2025 |
| SS Impex Solutions Ltd | Manufacturing | 2023 |
| Ssdp Digital Projects Ltd | Professional & scientific | 2026 |