| Saint Industries Limited | Manufacturing | 2022 |
| Saint Sophia (Norway) Biology Group Co., Ltd | Manufacturing | 2023 |
| Sainty Marine Corporation Ltd | Extraterritorial | 2020 |
| Sairui Trading Limited | Manufacturing | 2023 |
| Sajna Restaurant Limited | Hospitality | 2019 |
| Sakura Professional Services Ltd | Professional & scientific | 2024 |
| SAL Langley Ltd | Real estate | 2017 |
| Salguard Co., Limited | Extraterritorial | 2017 |
| Salimah Trading Co., Ltd | Wholesale & retail | 2021 |
| Sally Knight Consulting Ltd | Other services | 2017 |
| Sally Lettington Interiors Limited | Professional & scientific | 2023 |
| Sally Ornaments Co., Ltd | Extraterritorial | 2020 |
| Salmephar Ltd | Extraterritorial | 2022 |
| Salvo Traders Ltd | Wholesale & retail | 2025 |
| SAM Hancock Design Ltd | Professional & scientific | 2023 |
| SAM Hopper Associates Ltd | Professional & scientific | 2019 |
| Sama Health Limited | Health & social care | 2022 |
| Samo Control Technology Co., Ltd. | Extraterritorial | 2005 |
| Sample Instruments Limited | Extraterritorial | 2023 |
| SAMROB17 Ltd | Real estate | 2017 |
| Samsons Build & Developments Ltd | Construction | 2025 |
| Samspavs Ltd | Hospitality | 2026 |
| Samuel Silvester Ltd | Manufacturing | 2026 |
| Sanctuary Care Homes Limited | Health & social care | 2015 |
| Sanctuary Property Limited | Real estate | 2016 |
| Sand Properties Ltd | Real estate | 2026 |
| Sandi Technology Co., Limited | Extraterritorial | 2014 |
| Sandie Jones Limited | Arts & recreation | 2018 |
| Sandringham Mews MGT Co Ltd | Households | 2008 |
| Sandtin Limited | Extraterritorial | 2006 |
| Sanger London Ltd | Wholesale & retail | 2023 |
| Sanlian Industrial Limited | Extraterritorial | 2015 |
| Sanling Electromechanical Limited | Manufacturing | 2026 |
| Sann Remo Limited | Hospitality | 2024 |
| Santaway Development Ltd. | Manufacturing | 2024 |
| Santixos UK Ltd | Construction | 2018 |
| Sanve Trading (Yiwu) Co., Ltd | Extraterritorial | 2023 |
| Sanyi Fation Group Co., Ltd. | Wholesale & retail | 2021 |
| Sanyou Internation Group Limited | Wholesale & retail | 2016 |
| Sanyt Co., Ltd | Extraterritorial | 2020 |
| Sanz International (HK) Co., Limited | Extraterritorial | 2018 |
| Saparkle Limited | Manufacturing | 2021 |
| Sapiens System Co., Ltd | Extraterritorial | 2017 |
| Sapphire Recruitment Services Limited | Administrative & support | 2022 |
| SAR Croydon Limited | Real estate | 2025 |
| Sarah Bartle Limited | Professional & scientific | 2020 |
| Sarah Roberts Consulting Ltd | Professional & scientific | 2005 |
| Saran Consulting Limited | Information & communication | 2014 |
| Sares WIG Products R & D Center Co., Ltd | Wholesale & retail | 2022 |
| Sarios Limited | Other services | 2015 |
| Saro Logistic Limited | Construction | 2015 |
| Sarto Group Limited | Other services | 2016 |
| Sasa Trading Co., Ltd | Extraterritorial | 2023 |
| Satvia Yoga Studio Limited | Other services | 2023 |
| Sauce Pension 1960 Limited | Extraterritorial | 2014 |
| Savemax Lighting Co., Ltd | Extraterritorial | 2014 |
| Savgood Technology Co., Ltd. | Extraterritorial | 2014 |
| Savway Choice Limited | Extraterritorial | 2020 |
| Sawm Health & Beauty Limited | Other services | 2019 |
| SB Advisers Ltd | Education | 2020 |
| Sbilak Co., Ltd | Extraterritorial | 2024 |
| SBL Data Limited | Information & communication | 2024 |
| Scarecrow International Co., Ltd | Manufacturing | 2018 |
| Scarlett Vapes Ltd | Wholesale & retail | 2019 |
| Scene Limited | Real estate | 2002 |
| Schiegabor Machinery Limited | Extraterritorial | 2008 |
| Schnoor Electrical Co., Ltd | Extraterritorial | 2023 |
| Scholand Industry Company Limited | Extraterritorial | 2017 |
| Scholar Publishing Group Ltd | Extraterritorial | 2020 |
| Schoolsphere Ltd | Information & communication | 2026 |
| Schubert Academy of International Music Education | Education | 2022 |
| Scions Drainage & Groundwork Limited | Construction | 2013 |
| Sciorg Limited | Professional & scientific | 2023 |
| Scootasonix Ltd | Information & communication | 2022 |
| Score a BED Limited | Administrative & support | 2019 |
| Screen Print Films Ltd | Arts & recreation | 2014 |
| Screwfix Industrial Co., Ltd | Extraterritorial | 2016 |
| SD Industry Co., Ltd | Extraterritorial | 2011 |
| SDL Technology Investment Ltd | Wholesale & retail | 2016 |
| SDS Fitness Co., Ltd. | Extraterritorial | 2020 |
| SE Living Limited | Construction | 2000 |
| SE20 Construction Limited | Construction | 2022 |
| Sea Blue Aquatic Co Ltd. | Wholesale & retail | 2020 |
| Sea Eagle Labor Trade Co., Ltd | Extraterritorial | 2012 |
| Sea Harvest Foods Co., Ltd. | Wholesale & retail | 2025 |
| Sea Noble Marine Co., Ltd | Extraterritorial | 2024 |
| Sea Rich (Tianjin) Ship Service Co., Ltd | Manufacturing | 2021 |
| Sea Rich Foods Co., Ltd | Manufacturing | 2020 |
| Seaarea Technology Co., Ltd | Extraterritorial | 2014 |
| Seabird Industry Co., Ltd. | Extraterritorial | 2021 |
| Seafood Supplier Co., Ltd | Extraterritorial | 2014 |
| Seagarden Aquatic Co., Ltd | Wholesale & retail | 2019 |
| Seagry Limited | Construction | 1984 |
| Seakey Marine Equipment Co., Ltd | Extraterritorial | 2016 |
| Sealuck Marine Service &Engineering Co., Ltd | Manufacturing | 2023 |
| Seamark Shipping Co., Ltd. | Manufacturing | 2023 |
| Seamless Surfaces Limited | Construction | 2015 |
| Seamount Service Co., Ltd | Manufacturing | 2023 |
| Seaport Ship Service Co., Ltd | Manufacturing | 2022 |
| Searles Construction Ltd | Manufacturing | 2017 |