| Dockreay Property Services Ltd | Households | 2022 |
| Docsville Studios Limited | Information & communication | 2020 |
| Doctor Natalie Limited | Health & social care | 2015 |
| Dofi Financial Holdings Co., Ltd | Wholesale & retail | 2022 |
| Dokie Garments Ltd | Extraterritorial | 2019 |
| Dokiten Group (UK) Limited | Manufacturing | 2024 |
| Dolj Ltd | Transport & logistics | 2024 |
| Doll Properties Limited | Real estate | 2016 |
| Dolphin Marine Service Co., Ltd | Manufacturing | 2023 |
| Dolphins Group Co., Limited | Wholesale & retail | 2023 |
| Domingo Media Limited | Professional & scientific | 2020 |
| Dominic Farrow Limited | Professional & scientific | 2013 |
| DON Inspection Services Ltd | Professional & scientific | 2022 |
| Donegan Electrical Contractors Limited | Construction | 2014 |
| Donewey Corporation Limited | Manufacturing | 2024 |
| Dong Peng Marine Co. Limited | Extraterritorial | 2017 |
| Dong Rong Trade Co., Ltd | Extraterritorial | 2022 |
| Dongda Shipping Co., Ltd | Extraterritorial | 2025 |
| Dongfanghong Steel International Ltd | Manufacturing | 2024 |
| Dongguan DDC Apparel Co., Ltd | Extraterritorial | 2020 |
| Dongguan Yatto Industrial Limited | Extraterritorial | 2021 |
| Donghong Trading Ltd | Manufacturing | 2024 |
| Donglai Ltd | Wholesale & retail | 2021 |
| Dongyang ESA Import&Export Company Limited | Professional & scientific | 2018 |
| Dongyang Tongsheng Import and Export Co., Ltd | Extraterritorial | 2020 |
| Doni Group Ltd | Extraterritorial | 2021 |
| Doniyor International Company Limited | Wholesale & retail | 2023 |
| Dooren Co., Ltd | Wholesale & retail | 2025 |
| Doozy Beauty Limited | Extraterritorial | 2023 |
| Doran Reformative Maintenance Limited | Construction | 2024 |
| Dorgan Limited | Professional & scientific | 2016 |
| Dorling Interiors Limited | Construction | 2024 |
| DOS Lunas Cosmetic Co., Limited | Extraterritorial | 2018 |
| Dotin Promotion Co., Ltd | Wholesale & retail | 2016 |
| Doto International Trade Ltd | Extraterritorial | 2017 |
| Dott Electrical Technology Limited | Manufacturing | 2021 |
| Double Hight Ltd | Extraterritorial | 2021 |
| Double Leaf Trading Company Limited | Wholesale & retail | 2023 |
| Double Mode Ltd | Wholesale & retail | 2023 |
| Doug Co., Ltd | Information & communication | 2022 |
| Dougen Trading Ltd | Manufacturing | 2024 |
| Douglas House Management Company Limited | Households | 1994 |
| Dova Chemical Ltd | Extraterritorial | 2024 |
| Dovanft Industrial Co., Limited | Administrative & support | 2020 |
| Dowe International Limited | Wholesale & retail | 2024 |
| Dowell Industrial Co., Ltd | Wholesale & retail | 2014 |
| Dowling Consulting Engineering Limited | Construction | 2008 |
| Doya Kitchen Ltd | Hospitality | 2025 |
| DP AI Law Consulting Limited | Information & communication | 2024 |
| DP Optom Ltd | Health & social care | 2017 |
| Dq-Media Ltd | Extraterritorial | 2024 |
| DR R Kesse-Adu Limited | Health & social care | 2019 |
| DR Waste Removal Ltd | Water & waste | 2024 |
| Dr.Bigbio Holding Group Ltd | Extraterritorial | 2024 |
| Drachen Shipbrokers Limited | Manufacturing | 2024 |
| Dragon Aoxuan International Co., Ltd | Extraterritorial | 2022 |
| Dragon Car Wash Limited | Other services | 2016 |
| Dragon FLY Enterprises Ltd | Professional & scientific | 2014 |
| Dragonpass Capital Ltd. | Professional & scientific | 2025 |
| Dransfield Legal Limited | Professional & scientific | 2023 |
| DRC Asset Management Ltd | Financial services | 2012 |
| Dream Brand New Materials (Pingyi) Co., Ltd | Manufacturing | 2025 |
| Dream Cloud Innovation Limited | Information & communication | 2021 |
| Dream Family UK Ltd | Extraterritorial | 2020 |
| Dream Space Gaming Co., Ltd | Wholesale & retail | 2020 |
| Dreamcatcher Property Ltd | Real estate | 2022 |
| Dreamydiamonds Ltd | Wholesale & retail | 2022 |
| Dressler KBO Consulting Ltd | Professional & scientific | 2022 |
| DRH Corporate Services Ltd | Professional & scientific | 2024 |
| Drilltec Industries Co., Ltd. | Wholesale & retail | 2023 |
| Drim Equipment Limited | Manufacturing | 2024 |
| Driven First UK Car Hire Limited | Administrative & support | 2021 |
| DRJ Builders Limited | Construction | 2007 |
| Drongo Limited | Real estate | 2016 |
| DRS Manuraj & Sarita Singh Limited | Health & social care | 2018 |
| Drug Club Community Interest Company | Education | 2024 |
| DS Master Cleaning Ltd | Administrative & support | 2018 |
| DSG Media Ltd | Wholesale & retail | 2024 |
| DSG Property Services Limited | Households | 2013 |
| DSY Global Trading Co., Ltd. | Extraterritorial | 2016 |
| DTS Builders Limited | Construction | 2018 |
| DU Lifei Sanitary Ware Co., Ltd. | Manufacturing | 2021 |
| Du-Hope International Co., Ltd | Extraterritorial | 2011 |
| DUA. (UK) Limited | Other services | 2014 |
| DUC Khanh Vina Materials Co., Ltd | Mining & quarrying | 2021 |
| Duca Canevaro DI Zoagli Properties Ltd | Real estate | 2025 |
| Duex Industrial Co., Ltd | Extraterritorial | 2016 |
| Duffel Import and Export Trading Co., Ltd. | Extraterritorial | 2019 |
| Duka Construction Management Ltd | Construction | 2025 |
| Duker Chemical Company Limited | Extraterritorial | 2018 |
| Dulwich Ltd | Information & communication | 2018 |
| Dulwich Medical Services Limited | Health & social care | 2020 |
| Dulwich Sash Limited | Construction | 2017 |
| DUM (UK) Chymistry Engineering Group Ltd | Extraterritorial | 2022 |
| Dumbarton Consulting Services Limited | Administrative & support | 2010 |
| Duoduo Scarf Limited | Wholesale & retail | 2024 |
| Duomi Trade Co., Ltd. | Extraterritorial | 2023 |
| Durable Valve Parts Co., Limited | Wholesale & retail | 2023 |
| Durnford Estates Limited | Construction | 2010 |
| Dusty Digital Co., Ltd | Extraterritorial | 2021 |