| Saffron Court (High Wycombe) Ltd | Real estate | 2021 |
| Sagacial | Administrative & support | 2016 |
| Sagacious Consultancy Ltd | Professional & scientific | 2025 |
| Sagb Commercial Services Ltd | Hospitality | 2012 |
| SAI International Group Limited | Wholesale & retail | 2021 |
| Saket Estates Ltd | Real estate | 2019 |
| Sakura CPD Limited | Education | 2025 |
| SAL Recruitment Ltd | Administrative & support | 2026 |
| Salanti Ltd | Manufacturing | 2020 |
| Sales Management Solutions Europe Ltd. | Professional & scientific | 2010 |
| Salgo Investments Limited | Real estate | 2019 |
| Salt Holdings Ltd | Information & communication | 2019 |
| Salus Wealth Management Limited | Professional & scientific | 2019 |
| Samaya Entertainment Limited | Information & communication | 2025 |
| Samuel Leeds Dealconnect Ltd | Information & communication | 2023 |
| Samuel Leeds Developments (GP) Ltd | Real estate | 2023 |
| Samuel Leeds Developments (SG) Ltd | Real estate | 2023 |
| Samuel Leeds Developments Ltd | Real estate | 2017 |
| Samuel Leeds Finance Limited | Financial services | 2023 |
| Samuel Leeds Group Limited | Financial services | 2016 |
| Samuel Leeds Limited | Education | 2016 |
| Sanda&Maya Ltd | Real estate | 2017 |
| Sandforth Green Ltd | Professional & scientific | 2026 |
| Sarah Ferreira Interiors Ltd | Professional & scientific | 2026 |
| Sarkaria Asset Management Limited | Real estate | 2026 |
| Sathvis Consulting Limited | Information & communication | 2016 |
| Sats Recycling Ltd | Water & waste | 2023 |
| Saucy Horse Limited | Professional & scientific | 2011 |
| Savage & King Ltd. | Professional & scientific | 2013 |
| Savatar Consulting Limited | Other services | 2018 |
| Savatar Investments Limited | Real estate | 2023 |
| Savoir Faire Events Ltd | Other services | 2020 |
| Savoy Stirling Ltd | Real estate | 2019 |
| Sawaran Properties Limited | Real estate | 2025 |
| Sayed Healthcare Ltd | Health & social care | 2019 |
| SB Beaconsfield Ltd | Health & social care | 2024 |
| SBG Glazing Solutions Ltd | Construction | 2021 |
| SBH Birmingham Limited | Hospitality | 2015 |
| SBH Blackpool Limited | Hospitality | 2014 |
| SBH Cardiff Holding Ltd | Hospitality | 2025 |
| SBH Cardiff Ltd | Hospitality | 2023 |
| SBH City of Sheff Limited | Hospitality | 2015 |
| SBH Cliffden Ltd | Hospitality | 2018 |
| SBH Derby Holding Ltd | Hospitality | 2017 |
| SBH Derby Ltd | Hospitality | 2017 |
| SBH Gatwick Limited | Hospitality | 2015 |
| SBH Greenford Limited | Hospitality | 2022 |
| SBH Hospitality Ltd | Hospitality | 2013 |
| SBH Leases Ltd | Hospitality | 2026 |
| SBH Leeds Limited | Hospitality | 2010 |
| SBH Leicester Limited | Hospitality | 2015 |
| SBH Macleod Ltd | Hospitality | 2026 |
| SBH Park Holding Limited | Hospitality | 2016 |
| SBH Plymouth Limited | Hospitality | 2015 |
| SBH Ramsgate Limited | Hospitality | 2016 |
| SBH Styles Ltd | Hospitality | 2017 |
| SBH Tamworth Limited | Hospitality | 2016 |
| SBH Windermere Limited | Hospitality | 2017 |
| SC Counselling and Therapy Ltd | Real estate | 2018 |
| Scafell Securities Limited | Real estate | 1972 |
| Scene Global Ltd | Administrative & support | 2022 |
| Scene Partners Limited | Administrative & support | 2019 |
| Scope DC Consulting Ltd | Information & communication | 2026 |
| Scorefam UK Limited | Arts & recreation | 2024 |
| Scotswood Close Management Limited | Households | 1987 |
| Scott Cutters UK Limited | Administrative & support | 2008 |
| Sculpt Aesthetics Online Ltd | Other services | 2026 |
| SDE (Tuition) LLP | | 2018 |
| SDR Marketing Consultancy Ltd | Professional & scientific | 2026 |
| Sds.Tv Limited | Administrative & support | 2009 |
| Sdta Productions Limited | Information & communication | 2020 |
| SE1 Studios Limited | Professional & scientific | 2022 |
| Seagull Paediatric Occupational Therapy Limited | Health & social care | 2023 |
| Sean Collects Ltd | Professional & scientific | 2025 |
| Seasmic Engineering Ltd | Professional & scientific | 2022 |
| Seaward Strategic Land Ltd | Construction | 2022 |
| Sebe Ltd | Information & communication | 2009 |
| SEC PP Limited | Administrative & support | 2025 |
| Secore Information Security Limited | Information & communication | 2023 |
| Secret Speakeasy Limited | Arts & recreation | 2023 |
| Secure IT Technology Ltd | Information & communication | 2022 |
| Sede Ltd | Professional & scientific | 2016 |
| Seeburger UK Limited | Information & communication | 2000 |
| Seer Green Osteopaths Limited | Health & social care | 2009 |
| Segal Securities Limited | Real estate | 1951 |
| Seitech Limited | Information & communication | 2003 |
| Select 360 Coaching Ltd | Arts & recreation | 2026 |
| Selectivity Limited | Administrative & support | 2015 |
| Selene Quest Limited | Professional & scientific | 2023 |
| Selling Fast Limited | Wholesale & retail | 2024 |
| Sempe Ltd | Wholesale & retail | 2024 |
| Seneca Trading Limited | Wholesale & retail | 2020 |
| Sentinel Fire Protection Ltd | Professional & scientific | 2026 |
| Sentivale Limited | Administrative & support | 2003 |
| Sentry Care Limited | Health & social care | 2007 |
| Sequana Consulting Limited | Professional & scientific | 2017 |
| Sequelize Limited | Information & communication | 2004 |
| Serenade Sound UK Limited | Manufacturing | 2022 |
| Serendib Estates Limited | Real estate | 2019 |
| Serendipity Rose Limited | Information & communication | 2017 |