| Sohailsdesserts Ltd | Hospitality | 2026 |
| Solace Homecare Ltd | Health & social care | 2024 |
| Somna Living Ltd | Wholesale & retail | 2025 |
| Somna Sleep Ltd | Wholesale & retail | 2025 |
| Somnior Beds Ltd | Wholesale & retail | 2009 |
| Somnium Beds Ltd | Wholesale & retail | 2026 |
| Sonder Creative Ltd | Professional & scientific | 2014 |
| Soniclink Limited | Arts & recreation | 2024 |
| Southend Hall Limited | Real estate | 2000 |
| Sovah Interiors Ltd | Wholesale & retail | 2025 |
| Sovalis Ltd | Professional & scientific | 2022 |
| Sowerby Delight Halifax Ltd | Hospitality | 2025 |
| Spark Skills (UK) Ltd | Education | 2011 |
| Spec Box Limited | Water & waste | 2001 |
| Specialist Tiling & Building Supplies Limited | Wholesale & retail | 2023 |
| Spectre Legal Limited | Professional & scientific | 2026 |
| Spectrum Autos Limited | Wholesale & retail | 2003 |
| Speedo Logistics Limited | Transport & logistics | 2014 |
| Spices & Rices Ltd | Wholesale & retail | 2020 |
| Spider Orchid Management Limited | Professional & scientific | 2015 |
| Spiralpack Limited | Manufacturing | 2022 |
| Spiraltech Corporation Limited | Manufacturing | 2016 |
| Spiraltech Limited | Manufacturing | 2012 |
| Spmi Ltd | Administrative & support | 2017 |
| Spring Well Bedz Ltd | Wholesale & retail | 2022 |
| Springfield Oils Ltd | Manufacturing | 2019 |
| Springs Technology Limited | Wholesale & retail | 2016 |
| Springwell Microelectronics Limited | Manufacturing | 1994 |
| SPRUNG2 Ltd | Manufacturing | 2019 |
| SPS Locums Limited | Health & social care | 2023 |
| Squires Properties Ltd | Real estate | 2021 |
| Squirrel Hall Ltd | Real estate | 2025 |
| SR Lettings Ltd | Real estate | 2015 |
| SRA Pharma Limited | Wholesale & retail | 2023 |
| SRD Travel Ltd | Administrative & support | 2025 |
| SS Cafe Leeds Ltd | Hospitality | 2026 |
| SS Property and Construction Limited | Other services | 2019 |
| ST (Batley) Ltd | Arts & recreation | 2022 |
| Staccato Consultancy Limited | Information & communication | 2016 |
| Stags Head (Propco) Limited | Real estate | 2016 |
| Star Birstall Ltd | Hospitality | 2021 |
| Star Coaches of Batley Limited | Transport & logistics | 2003 |
| Starbrooke Events Ltd | Financial services | 2024 |
| Stariq Locums Ltd | Health & social care | 2020 |
| Starjumps Limited | Administrative & support | 2009 |
| Station Coaches Ltd | Administrative & support | 2017 |
| Station Road Studios Limited | Arts & recreation | 2015 |
| Status 1 Automotive Limited | Wholesale & retail | 2012 |
| Stayfit Gym Ltd | Arts & recreation | 2025 |
| Stephenson Transport Limited | Transport & logistics | 2002 |
| Steven Housecroft Tree Surgeon Limited | Administrative & support | 2016 |
| Stewart Plastering LLP | | 2006 |
| Stickyweb International Ltd | Wholesale & retail | 2015 |
| STK Catering Ltd | Hospitality | 2025 |
| Stonehouse Lettings Ltd | Real estate | 2021 |
| Storage BED Experts Ltd | Wholesale & retail | 2026 |
| Stormers Elite Cheerleading Limited | Education | 2026 |
| Strategies in Counter Extremism Theology Ltd | Administrative & support | 2017 |
| Strawberry Homes Limited | Households | 2024 |
| Strictly Come Turfing Ltd | Administrative & support | 2025 |
| Stride Ghost Ltd | Administrative & support | 2026 |
| Stride Launchz Ltd | Information & communication | 2025 |
| Stride Sales Ltd | Administrative & support | 2026 |
| Stridenex Holdings Ltd | Financial services | 2025 |
| Studio Rooms Group Ltd | Other services | 2021 |
| Stylo Beds Ltd | Manufacturing | 2019 |
| Sublime 7777 Ltd | Real estate | 2022 |
| Submerged Diving Limited | Wholesale & retail | 2020 |
| Subsea Inc. Ltd | Professional & scientific | 2024 |
| Sufi Care Limited | Administrative & support | 2014 |
| Sufi Cloth Ltd | Wholesale & retail | 2012 |
| Sufi's Halal Meat & VEG Ltd | Wholesale & retail | 2022 |
| Suiki Limited | Information & communication | 2021 |
| Sukkur Cuisine Ltd | Hospitality | 2010 |
| Sultana Optical Limited | Other services | 2022 |
| Sultry Lash Bar Ltd | Wholesale & retail | 2021 |
| Sun Offlicence Limited | Wholesale & retail | 2023 |
| Sunday Club Records Ltd | Information & communication | 2025 |
| Suneal Patel Ltd | Other services | 2019 |
| Sunie Nail Limited | Other services | 2026 |
| Sunnybank Stables Ltd | Administrative & support | 2017 |
| Supply Next Ltd | Wholesale & retail | 2025 |
| Sure Later Life Solutions Limited | Financial services | 2024 |
| Sustayn Travel Limited | Administrative & support | 2025 |
| SVE Autohouse Limited | Wholesale & retail | 2023 |
| Swan Auto Services Ltd | Wholesale & retail | 2019 |
| Sweets Fusion Ltd | Wholesale & retail | 2022 |
| Swell Group (Corp) Ltd | Real estate | 2025 |
| Swift Packing Ltd | Transport & logistics | 2023 |
| Swiftlee Travels Ltd | Transport & logistics | 2025 |
| Swink Design Ltd | Professional & scientific | 2010 |
| Swintoliving Ltd | Wholesale & retail | 2025 |
| Swipe Retail Ltd | Wholesale & retail | 2025 |
| Swis Group Ltd | Wholesale & retail | 2026 |
| Swiss House Medical Consulting Limited | Health & social care | 2016 |
| SWM Traders Ltd | Wholesale & retail | 2026 |
| Swypetech Limited | Information & communication | 2024 |
| Swys Optical Ltd | Health & social care | 2021 |
| SY Food Ltd | Hospitality | 2024 |
| SY One Holding Ltd | Other services | 2025 |