| S.A Beds Ltd | Wholesale & retail | 2018 |
| S.A.N Pathology Ltd | Health & social care | 2026 |
| S.K Rehab Limited | Professional & scientific | 2017 |
| S.K.S.Indo Limited | Construction | 2025 |
| S.M.K. Textiles Limited | Manufacturing | 2002 |
| S75 Architecture Ltd | Professional & scientific | 2019 |
| SA Healthcare Services Ltd | Health & social care | 2025 |
| Saaaz Homes Limited | Real estate | 2023 |
| Saad Nexus Ltd | Wholesale & retail | 2025 |
| Sabhar Ltd | Health & social care | 2025 |
| Sadar Khan and Co Ltd | Wholesale & retail | 2025 |
| SAE Installations Limited | Construction | 2017 |
| Safe Haven Residential Ltd | Health & social care | 2021 |
| Safe Move Properties Ltd | Real estate | 2020 |
| Safe Ridez Ltd | Transport & logistics | 2026 |
| Safe& Limited | Manufacturing | 2024 |
| Safer Deck Safety Solutions Ltd | Public administration | 2025 |
| Saffron Castle Investments Ltd | Real estate | 2026 |
| SAG Trading Ltd | Wholesale & retail | 2026 |
| Sahra Property Services Ltd | Households | 2023 |
| Saifali Kaji Ltd | Transport & logistics | 2026 |
| Sajjad Ahmad Store Ltd | Wholesale & retail | 2025 |
| Salt Diner Ltd | Hospitality | 2025 |
| Salu Medical Limited | Health & social care | 2019 |
| Salus Servicos Co Limited | Health & social care | 2025 |
| SAM Vapes Ltd | Wholesale & retail | 2026 |
| Sambob Ltd | Transport & logistics | 2016 |
| Samco (Yorks) Ltd | Transport & logistics | 2004 |
| Sampling Enterprise Holdings Limited | Financial services | 2023 |
| Sampling International Enterprises Limited | Manufacturing | 2019 |
| Sampson ISO Audit & Consult Ltd | Information & communication | 2025 |
| Sampson Products Ltd | Manufacturing | 2012 |
| Samuel Armitage & Sons,Limited | Wholesale & retail | 1923 |
| Sandoms Holdings Limited | Financial services | 2024 |
| Sandoms Interiors Limited | Manufacturing | 2011 |
| Sanipex Limited | Wholesale & retail | 2006 |
| Santrad Group Limited | Wholesale & retail | 2019 |
| Sapphire (Corp) Ltd | Real estate | 2025 |
| Sapphire Cafe Limited | Hospitality | 2021 |
| Sapphire Leeds Ltd | Hospitality | 2026 |
| Sappling Ltd | Wholesale & retail | 2024 |
| Sarah Taylor Dance Studios Ltd | Arts & recreation | 2022 |
| Sarah's Shinies Ltd | Wholesale & retail | 2023 |
| SAS Yorkshire Accountants Ltd. | Professional & scientific | 2019 |
| Savona Group Ltd | Wholesale & retail | 2019 |
| Saxton & Hunter Ltd | Manufacturing | 2025 |
| Sayle Group Ltd | Hospitality | 2022 |
| SB 1982 Limited | Professional & scientific | 2007 |
| SB Eyecare Limited | Health & social care | 2015 |
| SB Foods (Batley) Ltd | Hospitality | 2023 |
| SB Peer Boards Ltd | Administrative & support | 2019 |
| SB1981 Limited | Professional & scientific | 2006 |
| Sbespokebeds Limited | Manufacturing | 2026 |
| Sbrk Limited | Manufacturing | 2022 |
| Scbruce Commercials Limited | Wholesale & retail | 2016 |
| Schoolhouse Books Limited | Wholesale & retail | 2004 |
| Scibella Ltd. | Information & communication | 2014 |
| SCJ Consultants Limited | Professional & scientific | 2010 |
| Scoops of Yorkshire Limited | Manufacturing | 2023 |
| Scorb Ltd | Wholesale & retail | 2022 |
| Scott Auto Specialists Ltd | Wholesale & retail | 2007 |
| Screaming Cat Studios Ltd | Information & communication | 2023 |
| Scrubbit, Scratchit & Leggit Ltd | Professional & scientific | 2018 |
| Sculpte Ltd | Wholesale & retail | 2020 |
| Secondsell Ltd | Wholesale & retail | 2025 |
| Secret Rare Competitions Ltd | Arts & recreation | 2025 |
| Secure Giant Ltd | Extraterritorial | 2012 |
| Seedar Limited | Extraterritorial | 2024 |
| Seedara Limited | Real estate | 2025 |
| Seedat Butchers Limited | Wholesale & retail | 2017 |
| Seedat Holdings Ltd | Real estate | 2017 |
| Seekers Estates Ltd | Real estate | 2024 |
| Seekersguidance UK Ltd | Professional & scientific | 2020 |
| Sehriaraz Ltd | Wholesale & retail | 2022 |
| Sekai (World) Limited | Construction | 2018 |
| Selaro Ltd | Wholesale & retail | 2026 |
| Select Living Furniture Limited | Manufacturing | 2022 |
| Seller Ground Ltd | Wholesale & retail | 2022 |
| Sellers CBT Limited | Health & social care | 2013 |
| Sena Auto Logistics Ltd | Transport & logistics | 2024 |
| Sena Group Ltd | Administrative & support | 2024 |
| Sena Investments Ltd | Real estate | 2024 |
| Seneca Property 104 Limited | Real estate | 2019 |
| Senior Performance Ltd | Wholesale & retail | 2021 |
| Sentinara Security Solutions Ltd | Administrative & support | 2024 |
| Senty Ltd | Wholesale & retail | 2024 |
| Sephora Interiors Ltd | Manufacturing | 2024 |
| Serena Law Limited | Real estate | 2025 |
| Serene Beds Limited | Manufacturing | 2019 |
| Serene Holdings Limited | Real estate | 2014 |
| Serene Opulence Limited | Construction | 2024 |
| Sereno Beds Limited | Wholesale & retail | 2025 |
| Service House Limited | Administrative & support | 2010 |
| Seven Seeds Coffee Ltd | Hospitality | 2023 |
| Sfac Group Ltd | Other services | 2022 |
| SFQ Pharma Limited | Wholesale & retail | 2019 |
| SH Contract Roofing Ltd | Construction | 2025 |
| SH Professional Solutions Ltd | Professional & scientific | 2025 |
| Shadnan Facilities Management Limited | Administrative & support | 2024 |
| Shah & Raja Ltd | Real estate | 2024 |