| DE Smit Medical (Holdings) Ltd | Financial services | 2021 |
| DE Smit Medical Systems Limited | Wholesale & retail | 2008 |
| Deadline Accounting Ltd | Professional & scientific | 2001 |
| Dealyours Ltd | Wholesale & retail | 2023 |
| Deane Lettings Ltd | Real estate | 2025 |
| Debros Limited | Real estate | 2003 |
| Deception Detection LAB Ltd | Professional & scientific | 2024 |
| Decesare Arts and Technology Limited | Information & communication | 2013 |
| Decidit Ltd | Information & communication | 2014 |
| DEDLYNE2030 Limited | Information & communication | 2022 |
| Deep Blue Internet Limited | Information & communication | 2011 |
| Deep Blue Sky Digital Limited | Information & communication | 2008 |
| Deep Deep Games Ltd | Information & communication | 2023 |
| Deep Tech Consulting Limited | Professional & scientific | 2021 |
| Deepair Limited | Agriculture & fishing | 1997 |
| Deepseek Software Ltd | Energy | 2008 |
| Deepvault Ltd | Wholesale & retail | 2026 |
| Deer Deal Sourcing Ltd | Real estate | 2025 |
| Deernight Property Management Limited | Households | 1985 |
| Definitional Limited | Information & communication | 2014 |
| Dehaney's Commercial Cleaning Ltd | Administrative & support | 2026 |
| Deia Group Limited | Construction | 2012 |
| Dekdolly Ltd | Arts & recreation | 1991 |
| Delclair Limited | Administrative & support | 2025 |
| Delicia RAY Ltd | Manufacturing | 2021 |
| Delicomen Limited | Hospitality | 2017 |
| Deliver Change Limited | Professional & scientific | 2012 |
| Dell'Anna Interiors Ltd | Professional & scientific | 2023 |
| Dellow Associates Limited | Professional & scientific | 2007 |
| Delphi Accounting Ltd | Professional & scientific | 2002 |
| Delta Stone Capital Ltd | Real estate | 2022 |
| Deltashire Limited | Other services | 2001 |
| Deluxe Home Improvements Ltd | Construction | 2020 |
| Deluxewords Limited | Professional & scientific | 2017 |
| Demeter Sulis Ltd | Professional & scientific | 2019 |
| DEN South West Ltd | Construction | 2018 |
| Dendritic Technology Limited | Information & communication | 2025 |
| Denela`S Bakery Limited | Hospitality | 2006 |
| Denewood Property Group Limited | Construction | 2018 |
| Denholm Designs Limited | Wholesale & retail | 2013 |
| Denmon's Services Limited | Other services | 2012 |
| Denner Developments Limited | Real estate | 2022 |
| Dennis Moody Limited | Wholesale & retail | 2003 |
| Dennis Publishing Limited | Information & communication | 1973 |
| Denny Watson Limited | Administrative & support | 2012 |
| Derrick Worrell Transport Ltd | Transport & logistics | 2019 |
| Derw Consulting Ltd | Professional & scientific | 2019 |
| Derwent Solar 2 Limited | Energy | 2021 |
| Desacc Emea Ltd | Information & communication | 2009 |
| Desert Lion Limited | Extraterritorial | 2012 |
| Desiby Limited | Professional & scientific | 2025 |
| Design & Build (Bath) Limited | Wholesale & retail | 2003 |
| Design Central (Bath) Limited | Administrative & support | 1998 |
| Design for Digital Limited | Information & communication | 2013 |
| Design Garden Spaces Ltd | Other services | 2020 |
| Designability Limited | Professional & scientific | 2022 |
| Designscape Architects Limited | Professional & scientific | 2005 |
| Despacio RE Ltd | Real estate | 2024 |
| Desto Ltd | Information & communication | 2025 |
| Detari Ltd | Construction | 2024 |
| Detoxdecarb Ltd | Administrative & support | 2024 |
| Developing Health and Independence | Hospitality | 1999 |
| Development 6 Limited | Construction | 2017 |
| Devenish Property Company Limited | Real estate | 2025 |
| Deverell Innovation Ventures Limited | Financial services | 2019 |
| Devmatic Limited | Information & communication | 2011 |
| Devmonki Ltd | Information & communication | 2019 |
| Devon Country Hotels Ltd | Hospitality | 2021 |
| Devon Garden Foods Limited | Manufacturing | 2018 |
| Devon Retreat Ltd | Hospitality | 2002 |
| Devonport Developments Ltd | Construction | 2020 |
| DEX Marketing Ltd | Professional & scientific | 2025 |
| Dexter's Coffee Shop Ltd | Hospitality | 2019 |
| Dezy's Tours and Travels Ltd | Administrative & support | 2025 |
| DHA (UK) Limited | Wholesale & retail | 2003 |
| Dhilal for Training, Consultancy & Media Services Ltd | Education | 2024 |
| Diagnohealth Clinic Limited | Health & social care | 2023 |
| Dialect Limited | Information & communication | 2015 |
| Dials at Brabazon Management Company Limited | Households | 2020 |
| Diary of an SEO Limited | Professional & scientific | 2023 |
| Dicasa Ltd | Real estate | 2024 |
| Dicecrown Limited | Real estate | 2005 |
| Dick Willows Ltd | Professional & scientific | 2021 |
| Dicketts Road Management Company Limited | Households | 2011 |
| Dicorato Investments Ltd | Financial services | 2026 |
| Didicakes Limited | Hospitality | 2017 |
| Digilanti Ltd | Professional & scientific | 2019 |
| Digital Custody Nominees Limited | Financial services | 2017 |
| Digital Development Space Limited | Administrative & support | 2016 |
| Digital DNA LLP | | 2007 |
| Digital Drink Dispensers Limited | Information & communication | 2016 |
| Digital Mews Ltd | Wholesale & retail | 2023 |
| Digital Mojo Limited | Information & communication | 2009 |
| Digital Pension Trustees Limited | Financial services | 2017 |
| Digital Wonderlab Limited | Information & communication | 2008 |
| Digitalandstone Ltd | Other services | 2023 |
| Diluculo Ltd | Professional & scientific | 2019 |
| Dimension 22 Ltd | Professional & scientific | 2020 |
| Dimension Vintage Limited | Wholesale & retail | 2021 |
| Dinh Limited | Financial services | 2023 |