| Shadow Tinting and Customs Ltd | Other services | 2014 |
| Shahi Family Property Limited | Real estate | 2020 |
| Shamana Ltd | Wholesale & retail | 2023 |
| Shane Hollamby Limited | Construction | 2019 |
| Shanked IT Co. Limited | Wholesale & retail | 2025 |
| Sharden Services Limited | Financial services | 2013 |
| Sharpe Consultants Limited | Information & communication | 2009 |
| Shatari Properties Ltd | Real estate | 2024 |
| Shatari Property Group Ltd | Real estate | 2026 |
| Shattered Ceiling Coaching Ltd | Professional & scientific | 2025 |
| Shaw Properties Ltd | Real estate | 2019 |
| Shazab Global Trade Limited | Wholesale & retail | 2025 |
| Sheng SHI China Limited | Hospitality | 2014 |
| Shenton HR Solutions Ltd | Administrative & support | 2022 |
| Shepherd Homes UK Ltd | Construction | 2026 |
| Shepherds Walk Residents Company Limited | Households | 2019 |
| Sheq Management Solutions Limited | Professional & scientific | 2013 |
| Sherborne Veterinary Services Ltd | Professional & scientific | 2020 |
| Sherfield Advisors Ltd | Administrative & support | 2016 |
| Sherfield Coffee Shop Limited | Transport & logistics | 2020 |
| Sherringtons Accountants Limited | Professional & scientific | 2006 |
| Sherringtons Financial Services Limited | Extraterritorial | 2009 |
| Sherringtons LLP | | 2006 |
| SHI FW UK Ltd | Professional & scientific | 2022 |
| Shield Cleaning Limited | Administrative & support | 2020 |
| Shiftcam Emea Ltd | Wholesale & retail | 2019 |
| Shiloh Limited | Professional & scientific | 1953 |
| Shine Transport Links Limited | Transport & logistics | 2024 |
| Shinye Ltd | Professional & scientific | 2025 |
| Shinzer Properties Ltd | Real estate | 2023 |
| Ship Valuation Consultancy Limited | Professional & scientific | 2003 |
| Shire Nutrition Limited | Administrative & support | 2016 |
| Shiva Consulting Ltd | Hospitality | 2020 |
| Shloka Consultancy Ltd | Information & communication | 2012 |
| Shooting Stars Nursery School Limited | Education | 2019 |
| Shop Kushti Ltd | Wholesale & retail | 2025 |
| Shop on TV Ltd | Wholesale & retail | 2023 |
| Shop Patrol Ltd | Wholesale & retail | 2025 |
| Shop Space Collective Ltd | Real estate | 2008 |
| Shopsy Ltd | Wholesale & retail | 2024 |
| Shorenam Holdings Limited | Financial services | 2019 |
| Short Lets Basingstoke Limited | Real estate | 2017 |
| Shorthouse & Martin Limited | Professional & scientific | 1992 |
| Shree Construction Ltd | Construction | 2025 |
| Shrewd Investment Marketing Limited | Professional & scientific | 2018 |
| Shubam Healthcare Ltd | Health & social care | 2019 |
| Sibbz Limited | Administrative & support | 2025 |
| Sichef Ltd | Hospitality | 2023 |
| Sidat Marketing Ltd | Administrative & support | 2012 |
| Sierra Security Ltd | Information & communication | 2024 |
| Sight Care Services Limited | Administrative & support | 1990 |
| Sigma CNC Limited | Manufacturing | 2007 |
| Signature Distributors UK Limited | Wholesale & retail | 2024 |
| Signature Private Clients Limited | Professional & scientific | 2012 |
| Signature Smile Tenbury Ltd | Health & social care | 2019 |
| Signomatrix Ltd | Professional & scientific | 2022 |
| Signway (Holdings) Limited | Manufacturing | 2012 |
| Signway Supplies (Datchet) Limited | Manufacturing | 1979 |
| Sigtech Ltd | Professional & scientific | 2023 |
| Silent Noise Ltd. | Wholesale & retail | 2024 |
| Sileo Ltd | Financial services | 2025 |
| Silmar Construction Ltd | Construction | 2023 |
| Silvanas Restaurant Ltd | Hospitality | 2023 |
| Silverbulb Limited | Professional & scientific | 2007 |
| Silverwolf Properties Ltd | Real estate | 2022 |
| Simeks Ltd | Wholesale & retail | 2014 |
| Simo & BG Ltd | Transport & logistics | 2024 |
| Simon James Electrical Ltd | Construction | 2017 |
| Simon James Spaces Ltd | Real estate | 2024 |
| Simpila Limited | Professional & scientific | 2016 |
| Simple MAY Ltd | Wholesale & retail | 2018 |
| Simple Plan Studio Ltd | Professional & scientific | 2023 |
| Simply Fabs Ltd | Wholesale & retail | 2013 |
| Simply Helpful Ltd | Information & communication | 2013 |
| Simply Search Ltd | Professional & scientific | 2011 |
| Simply SOLUTIONS4U Ltd | Other services | 2024 |
| Simpsons Serene Property Ltd | Real estate | 2026 |
| Sinclair Autoworks Ltd | Wholesale & retail | 2025 |
| Sindicorp Ltd | Information & communication | 2022 |
| Sips Coffee and Protein Ltd | Hospitality | 2025 |
| SIS & Co Cleaning Services Ltd | Administrative & support | 2025 |
| Site Pilot Solutions Limited | Information & communication | 2025 |
| Site to Site Transport Limited | Professional & scientific | 2022 |
| Sitemaster Supplies Limited | Wholesale & retail | 1997 |
| Sitemaster Supplies Trustees Limited | Financial services | 2025 |
| Siyali Limited | Professional & scientific | 2012 |
| SJ & Sons Enterprises Limited | Education | 2018 |
| SJ LOGISTICS1 Ltd | Transport & logistics | 2024 |
| Sjak Consulting Limited | Information & communication | 2012 |
| Sjcee Ltd | Wholesale & retail | 2022 |
| SJCLEANINGS4U Ltd | Administrative & support | 2021 |
| Sjktech Ltd | Information & communication | 2024 |
| SJS Construction Consultancy Limited | Construction | 2015 |
| SJW Bookkeeping Limited | Professional & scientific | 2022 |
| Skhi Homes Ltd | Real estate | 2026 |
| Skhi Properties Ltd | Real estate | 2022 |
| Skillcollective Ltd | Professional & scientific | 2013 |
| Skillset Limited | Information & communication | 1992 |
| Skin and Co Aesthetics Ltd | Other services | 2022 |
| Skin Sanctuary Aesthetics Limited | Other services | 2022 |