| Saanvi Consulting Private Limited | Information & communication | 2019 |
| Saashvi Limited | Real estate | 2024 |
| Saastemic Ltd | Information & communication | 2025 |
| Saax Ltd | Information & communication | 2016 |
| Sabehia Consulting Limited | Professional & scientific | 2006 |
| Sabr Ltd | Professional & scientific | 2020 |
| Sacatana Limited | Professional & scientific | 2024 |
| Sadikshya Limited | Real estate | 2025 |
| Safari Sunrise Limited | Wholesale & retail | 2021 |
| Safelan Solutions Limited | Wholesale & retail | 2018 |
| Safinat Investments Limited | Wholesale & retail | 2022 |
| Saftdwin Limited | Wholesale & retail | 1979 |
| Sage Counsel Ltd | Professional & scientific | 2026 |
| Sage Psychology Services Ltd | Health & social care | 2021 |
| Saha Sphere Ltd | Wholesale & retail | 2024 |
| Sahaj Homes Ltd | Real estate | 2025 |
| SAI Global Estate Ltd | Real estate | 2025 |
| SAI Health Ltd | Health & social care | 2023 |
| SAI Oracle Consulting Ltd | Information & communication | 2014 |
| SAI Pragman Limited | Information & communication | 2025 |
| SAI Ranga Consulting Limited | Information & communication | 2026 |
| SAI Srinainika Investments Ltd | Real estate | 2024 |
| Saii Krupa Ltd | Hospitality | 2026 |
| Saint Bidco Limited | Information & communication | 2021 |
| Saint John Architectural Interiors Limited | Extraterritorial | 2018 |
| Saint Topco Limited | Information & communication | 2021 |
| Saleha GP Limited | Health & social care | 2022 |
| Salon Care Limited | Manufacturing | 2000 |
| Salters Renovations and Builders Ltd | Construction | 2016 |
| Salvadoran Nostalgic Distributors Ltd | Wholesale & retail | 2024 |
| SAM Allen Counselling Therapy Ltd | Health & social care | 2021 |
| SAM Distribution UK Ltd | Wholesale & retail | 2024 |
| Samagri Limited | Wholesale & retail | 2008 |
| Samantha Beeston Ltd | Professional & scientific | 2022 |
| Same Construct Ltd | Construction | 2024 |
| Saml Consulting Limited | Information & communication | 2014 |
| Sampahim Ltd | Wholesale & retail | 2023 |
| Samsara Tattoos Limited | Other services | 2022 |
| Sana Essencia Ltd | Manufacturing | 2026 |
| Sanctuary Angel Properties Ltd | Real estate | 2019 |
| Sanctuary Renovations & Interiors Ltd | Manufacturing | 2024 |
| Sand-Glass Recruitment Limited | Administrative & support | 2025 |
| Sandflo Trans Ltd | Wholesale & retail | 2022 |
| Sandford Homes Limited | Construction | 2011 |
| Sandford Springs Limited | Arts & recreation | 1990 |
| Sandown Surrey and Hampshire Limited | Wholesale & retail | 1995 |
| Sandra DE Creations Ltd | Hospitality | 2025 |
| Sangay Menlha Ltd | Health & social care | 2022 |
| Sangs (Frimley) Management Company Limited | Households | 2016 |
| Sanjeev Dayal Investments Ltd | Real estate | 2020 |
| Sanjeev Dayal Ltd | Financial services | 2018 |
| Sansman Limited | Information & communication | 2015 |
| Sant Logistics Ltd | Transport & logistics | 2018 |
| Santi & Springs 306 Ltd | Real estate | 2025 |
| Sapley Farm Limited | Agriculture & fishing | 2026 |
| Sapphire Key Property Solutions Ltd | Hospitality | 2025 |
| Sapumanage Limited | Wholesale & retail | 2025 |
| Sara Transport Ltd | Transport & logistics | 2024 |
| Sara Weller SW Ltd | Professional & scientific | 2025 |
| Sarah Lucas Properties Limited | Construction | 2024 |
| Sargeant Systems Ltd | Professional & scientific | 2026 |
| Sarum House Consulting Limited | Professional & scientific | 2012 |
| SAS Commercial Properties Holding Ltd | Real estate | 2024 |
| Sasasl Ltd | Professional & scientific | 2025 |
| Sasi Global Ltd | Professional & scientific | 2025 |
| Satyasookhun Limited | Real estate | 2024 |
| Saunaglo Ltd | Other services | 2026 |
| Sauter Automation Limited | Construction | 1976 |
| SAV Group Ltd | Wholesale & retail | 2021 |
| SAV Housing Limited | Real estate | 2018 |
| Savan Testing Services Ltd | Information & communication | 2014 |
| Saville-Nugent Ltd | Real estate | 2025 |
| Savorstories Ltd | Hospitality | 2025 |
| Savvii Group Ltd | Hospitality | 2014 |
| Saxnōt Meadery Limited | Manufacturing | 2022 |
| Saxtondavies Highways Ltd | Professional & scientific | 2019 |
| SB Digital Limited | Administrative & support | 2023 |
| SB Software Solutions Limited | Information & communication | 2012 |
| SB Transport Limited UK Ltd | Transport & logistics | 2026 |
| Sbhh Limited | Wholesale & retail | 2022 |
| SBP & H (Kempshott) Ltd | Construction | 2025 |
| SBS Partnership Limited | Professional & scientific | 1998 |
| Sbsl Group Limited | Financial services | 2025 |
| SC Cine Ltd | Information & communication | 2016 |
| SC Home Services Limited | Construction | 2026 |
| Scalex Ltd | Manufacturing | 2026 |
| Scan Resource Limited | Wholesale & retail | 2010 |
| Scarlet Hunt Design Ltd | Professional & scientific | 2014 |
| SCD Property Development Ltd | Real estate | 2023 |
| SCG Cloud Limited | Information & communication | 1999 |
| SCG Corporate Limited | Information & communication | 1991 |
| SCG Midlands Limited | Information & communication | 1991 |
| SCG South West Limited | Information & communication | 1999 |
| SCG Wales Group Limited | Information & communication | 2024 |
| SCH Carpentry Limited | Construction | 2026 |
| Schools Finance Direct Limited | Financial services | 2020 |
| Science Projects | Manufacturing | 1987 |
| Science Projects Interactives Ltd | Manufacturing | 2026 |
| Scientific Research Private Limited | Professional & scientific | 2010 |
| Scilla Stevens Consultancy Ltd | Information & communication | 2016 |