| Sempra Homes Limited | Construction | 2014 |
| Sense Traxx Limited | Information & communication | 2016 |
| Sentinel Private Equity Ltd | Financial services | 2014 |
| Sentinel Secure Ltd | Information & communication | 2017 |
| Sentinel Secure Solutions Ltd | Information & communication | 2019 |
| Septem House LLP | | 2026 |
| Serby Ltd | Construction | 2019 |
| Serendipity Nursery Ltd | Education | 2011 |
| Serf Electrical Ltd | Construction | 2023 |
| Serious Nature Ltd | Professional & scientific | 2020 |
| Serrano Capital Limited | Financial services | 2024 |
| SERVICE24HR Limited | Wholesale & retail | 2020 |
| SES Investment Management Company Ltd | Professional & scientific | 2008 |
| SET to Stage Ltd | Construction | 2023 |
| Sevara Estates Ltd | Real estate | 2026 |
| Seven Beauty Wellbeing Ltd | Other services | 2025 |
| Seven Eight SIX Real Estate Limited | Real estate | 2017 |
| Seven Two Seven Designs Limited | Professional & scientific | 2009 |
| Seventh Incarnation Limited | Information & communication | 2021 |
| Seventy 2017 Limited | Administrative & support | 2017 |
| Severn Valley Retreats Ltd | Hospitality | 2026 |
| Sevki Sahin Ltd | Hospitality | 2014 |
| Seyon Consulting Solutions Limited | Information & communication | 2025 |
| SFQ Properties & Lettings Ltd | Real estate | 2024 |
| SGD Contractors Limited | Construction | 2013 |
| SGM Property Investments (Holdings) Limited | Financial services | 2025 |
| SGM Property Investments Limited | Real estate | 2025 |
| SGM Windows (Holdings) Limited | Financial services | 2016 |
| SGM Windows Group Limited | Financial services | 2025 |
| SGM Windows Manufacturing Limited | Manufacturing | 2004 |
| SGM Windows Trustee Limited | Extraterritorial | 2025 |
| Sgproprep Ltd | Construction | 2026 |
| Sgsa Electrical Limited | Construction | 2019 |
| SH Bodyworks Limited | Wholesale & retail | 2025 |
| SH Construction Consulting Ltd | Professional & scientific | 2015 |
| SH Consultancy (U.K) Limited | Professional & scientific | 2025 |
| SH Drums Limited | Education | 2024 |
| SHA Fitness Limited | Arts & recreation | 2025 |
| Shadow- Moon K9 Products Limited | Extraterritorial | 2017 |
| Shaine Mountier Ltd | Hospitality | 2025 |
| Shaky Golf Ltd | Wholesale & retail | 2024 |
| Shalo Ltd | Transport & logistics | 2021 |
| Shalom Driver Hire Ltd | Administrative & support | 2019 |
| Shannon's Aesthetics Limited | Health & social care | 2024 |
| Shannon's Groundworks and Civils Limited | Construction | 2015 |
| Shapes Construction Limited | Construction | 2023 |
| Sharnee’S Hair & Beauty Limited | Other services | 2021 |
| Sharnee’S Hair Extensions Limited | Other services | 2025 |
| Sharon Rose Holdings Ltd | Financial services | 2018 |
| Sharp Funding Solutions Ltd | Professional & scientific | 2020 |
| Sharp Shines Ltd | Administrative & support | 2025 |
| Sharpfibre (UK) Ltd | Construction | 2025 |
| Sharpfibre Limited | Construction | 1987 |
| Shavlon Ltd | Real estate | 2024 |
| Shayspace Living Ltd | Real estate | 2025 |
| SHB Construction Limited | Construction | 2017 |
| Shbc Ltd | Professional & scientific | 2010 |
| SHD Training and Business Solutions Limited | Other services | 2015 |
| SHE Connects, YOU Thrive Limited | Administrative & support | 2024 |
| Shearing Electrical Services Ltd | Construction | 2020 |
| Sheba Entertainment Company Ltd | Arts & recreation | 2021 |
| Sheena Gali Limited | Health & social care | 2015 |
| Sheila James Ltd. | Information & communication | 2021 |
| Shellybelly's Ltd. | Hospitality | 2014 |
| Shelter Essex Roofing & Building Ltd | Construction | 2026 |
| Shelving Storage Solutions Ltd | Wholesale & retail | 2025 |
| Sheqmate Consultancy Services Limited | Professional & scientific | 2015 |
| Sherdeth & Daughters Limited | Health & social care | 2014 |
| Sherrygrade Limited | Professional & scientific | 1983 |
| Shield Electrical Limited | Construction | 2002 |
| Shield Fire, Safety and Security Limited | Manufacturing | 2004 |
| Shield Medica Limited | Manufacturing | 2014 |
| Shilbys Company Private Limited | Health & social care | 2021 |
| Shimmy 'N' Groove Fitness Ltd | Arts & recreation | 2013 |
| Shine Bright Pro Clean Ltd | Administrative & support | 2026 |
| Shine Right Cleans Ltd | Administrative & support | 2025 |
| Shiny Northwick HCW Ltd | Other services | 2014 |
| Shipco-Shipping Limited | Extraterritorial | 1988 |
| Shipman Security Systems Limited | Construction | 2003 |
| SHJ Homes Ltd | Real estate | 2021 |
| Shopsphere Hub Limited | Wholesale & retail | 2025 |
| Shorone Company Ltd | Health & social care | 2019 |
| Shortstown Consultancy Limited | Information & communication | 2010 |
| Showbites Ltd | Hospitality | 2023 |
| SHR Technologies Ltd | Information & communication | 2023 |
| Shravs Limited | Wholesale & retail | 2018 |
| Shree Nithi Limited | Information & communication | 2013 |
| Shree RB Properties LLP | | 2022 |
| Shreeya Property Investments Ltd | Financial services | 2024 |
| Shri Saarangan Arts Ltd | Manufacturing | 2022 |
| Shure Care Limited | Real estate | 2021 |
| Shuttertec Ltd | Wholesale & retail | 2016 |
| SI Contracts Ltd | Construction | 2019 |
| SIA DAN Ltd | Other services | 2016 |
| SIA Design Construction Ltd | Construction | 2024 |
| SIB Security Ltd | Construction | 2024 |
| SID Concept Ltd | Construction | 2025 |
| Sidal Services Ltd | Administrative & support | 2026 |
| Side Hustle Trading Limited | Other services | 2026 |
| Sieg Holdings Limited | Real estate | 2010 |