| Daynet Services Limited | Information & communication | 1995 |
| Dazzle for Children and Young People CIC | Health & social care | 2014 |
| DB Renewables Limited | Administrative & support | 2012 |
| DDJ Developments Ltd | Construction | 2024 |
| DE Roxas Global Limited | Wholesale & retail | 2022 |
| Deadlight Apparel Ltd | Wholesale & retail | 2026 |
| Deams Engineering Limited | Professional & scientific | 2021 |
| Defcon Limited | Other services | 2022 |
| Deltawaite Properties Ltd. | Administrative & support | 1942 |
| Densam Ltd | Hospitality | 2018 |
| Densons Engineering Limited | Professional & scientific | 2012 |
| Derian Engineering Limited | Manufacturing | 1994 |
| Derian Engineering Solutions Limited | Manufacturing | 2009 |
| Dervis Ltd | Hospitality | 2023 |
| DES Johnston Recruitment Limited | Professional & scientific | 2017 |
| Descend Mountain Bike Clothing Ltd | Wholesale & retail | 2026 |
| Destination Foods Limited | Hospitality | 2016 |
| Devereux Joinery Ltd | Construction | 2025 |
| Devro Barber Shop Ltd | Other services | 2009 |
| Dewams Limited | Professional & scientific | 2014 |
| DGSA-CPC(2018) Ltd | Transport & logistics | 2018 |
| Diam Trading Ltd | Wholesale & retail | 2013 |
| Different Angle Photography Limited | Professional & scientific | 2022 |
| Digital Dreadnought Ltd | Information & communication | 2020 |
| Dipower Limited | Wholesale & retail | 2025 |
| Disma Systems Ltd | Information & communication | 2026 |
| DJ PEP Limited | Other services | 2002 |
| DJM Event Ltd | Other services | 2024 |
| DJM Joinery & Building Ltd | Construction | 2026 |
| DLJ Offshore Ltd | Construction | 2012 |
| DLW Company Formation Services 0013 Limited | Extraterritorial | 2013 |
| Dlwl Home Rentals Ltd | Real estate | 2023 |
| DMH Subsea Limited | Professional & scientific | 2017 |
| DND Accountancy Services Limited | Professional & scientific | 2009 |
| Dodona House Ltd | Hospitality | 2021 |
| Dolocano Limited | Hospitality | 2018 |
| Douglas Bookkeeping Limited | Administrative & support | 2025 |
| Downtown Diner Group Ltd | Hospitality | 2018 |
| Dowsett Capital Group Ltd | Financial services | 2026 |
| Dowsett Property Group Limited | Real estate | 2022 |
| DPD Preston Ltd | Transport & logistics | 2025 |
| DR Lorna Robinson Psychology Ltd | Health & social care | 2025 |
| DR Service Management Ltd | Households | 2015 |
| Dragon Barrow Ltd | Hospitality | 2025 |
| DRC Render Systems Ltd | Construction | 2024 |
| Drivethedream Limited | Wholesale & retail | 2016 |
| Drop Zone Youth Projects Ltd. | Education | 2007 |
| Drygrip Ltd | Manufacturing | 2024 |
| DS Training (Barrow) Limited | Arts & recreation | 2008 |
| DT Groupnw Ltd | Construction | 2025 |
| Duddon Tyres Limited | Wholesale & retail | 2000 |
| DUO Sleep Limited | Wholesale & retail | 2024 |
| DW Commercial Services Limited | Professional & scientific | 2021 |
| DW Painting & Decorating Ltd | Construction | 2023 |
| Dylbert Ltd | Administrative & support | 2019 |
| Dymond Residential Limited | Real estate | 2016 |
| Dynamic Cleaning & Maintenance Limited | Administrative & support | 2025 |
| Dynasty Distribution Ltd | Professional & scientific | 2014 |
| E Shelf Ltd | Wholesale & retail | 2025 |
| E-Motorrepairs Ltd | Wholesale & retail | 2024 |
| E.L.G Limited | Wholesale & retail | 2025 |
| E.S.Mason&Sons Limited | Wholesale & retail | 2023 |
| E.U.S. Properties Limited | Real estate | 1998 |
| Earnsebaykitesurfing Limited | Arts & recreation | 2021 |
| Easyclean (Cumbria) Ltd | Other services | 2005 |
| Eaton PL Limited | Real estate | 2024 |
| Eats Group Holdings Limited | Financial services | 2022 |
| Eats Marketplaces Limited | Hospitality | 2025 |
| Eco 4 Power Ltd | Construction | 2023 |
| EDC Skilled Services Ltd | Construction | 2026 |
| Eden Property Lettings & Management Ltd | Real estate | 2018 |
| EDS HV Group Limited | Financial services | 2016 |
| EDS HV Management Limited | Construction | 2014 |
| Edwards Project Management Services Limited | Professional & scientific | 2016 |
| Efflorescence Ltd | Wholesale & retail | 2008 |
| Eggandcosa Ltd | Hospitality | 2017 |
| Ehlers Danlos Syndrome Advocacy and Awareness Limited | Health & social care | 2026 |
| Eivissa Services Limited | Professional & scientific | 2016 |
| Elantel Services Ltd | Professional & scientific | 2020 |
| Elconn Ltd | Administrative & support | 2025 |
| Electricity Distribution Services Limited | Construction | 2003 |
| Elegant Curtains and Blinds Limited | Manufacturing | 2014 |
| Elegant Products Limited | Construction | 2009 |
| Elephant Production Management Limited | Wholesale & retail | 2010 |
| Elevate HER Collective CIC | Education | 2025 |
| Elint Consultancy Services Ltd | Information & communication | 2022 |
| Elite Estates Management Ltd | Construction | 2025 |
| Elizabeth Taylor Beauty Limited | Other services | 2017 |
| ELL2COOP Limited | Hospitality | 2008 |
| Ellagills Touch Ltd | Other services | 2026 |
| Elliot & Caddell Ltd | Transport & logistics | 2025 |
| Elliott Plumbing Ltd | Construction | 2018 |
| Ellwood House Limited | Hospitality | 2016 |
| Emlyn Street Tyre Services Limited | Wholesale & retail | 2025 |
| Emmanuel Joinery Limited | Manufacturing | 2019 |
| Empat Removals Limited | Transport & logistics | 2001 |
| Enchanted Bridal Cumbria Limited | Other services | 2019 |
| Encounter Culture CIC | Arts & recreation | 2025 |
| Energen Group Ltd | Professional & scientific | 2025 |
| ENERGY4ALL Limited | Other services | 2002 |