| Sandher Estates Ltd | Real estate | 2018 |
| Sandy GAP C.I.C. | Arts & recreation | 2014 |
| Santa Marina Limited | Hospitality | 2020 |
| Sapphire Motor Cycles Ltd | Wholesale & retail | 2012 |
| Sarah Osmond Interiors Limited | Other services | 2016 |
| Sarah Wilson Hygienist Limited | Health & social care | 2013 |
| Satc Ltd | Construction | 2017 |
| Savji Price Management Limited | Construction | 2020 |
| SB Cleaning Ltd | Administrative & support | 2025 |
| SB1 Holdco Limited | Financial services | 2022 |
| SC Marine Projects Ltd | Manufacturing | 2019 |
| SC1 Holdco Limited | Financial services | 2022 |
| Scantech Offshore Limited | Administrative & support | 1998 |
| Scentventure Limited | Other services | 2022 |
| School View Askam Management Limited | Households | 2022 |
| Sciac Ltd | Information & communication | 2026 |
| Scuffz Automotive Refinishers Ltd | Wholesale & retail | 2025 |
| Scurrah-Nassau Limited | Manufacturing | 1973 |
| SCW Transport Ltd | Transport & logistics | 2024 |
| Seahouse Media CIC | Manufacturing | 2022 |
| Searchlite Talent Ltd | Administrative & support | 2025 |
| Seawinds Group Ltd | Manufacturing | 2026 |
| Secure Scaffolding (Morecambe) Limited | Construction | 2019 |
| Seek Social Ltd | Professional & scientific | 2017 |
| Seenlocal Limited | Professional & scientific | 2025 |
| Seiga Housing Limited | Real estate | 2020 |
| Seiga Limited | Other services | 2018 |
| Sell IT on Limited | Wholesale & retail | 2018 |
| Seniiah Ltd | Other services | 2024 |
| Sequoia Operations Limited | Financial services | 2023 |
| Servicecultureclub Limited | Administrative & support | 2017 |
| Sevgi Food Ltd | Hospitality | 2026 |
| Shahin Samadi Ltd | Wholesale & retail | 2017 |
| Sharpe Engineering Services Ltd | Manufacturing | 2019 |
| Shaun Beach Limited | Construction | 2002 |
| Shaw Digital Services Ltd | Wholesale & retail | 2026 |
| Shazam Ltd | Hospitality | 2017 |
| Sheet Haus Ltd | Manufacturing | 2025 |
| Shepherd A&S Ltd | Professional & scientific | 2014 |
| Shergar Properties NW Ltd | Real estate | 2026 |
| Shieldwolf Limited | Administrative & support | 2023 |
| Shiny Crystal Hand Wash Ltd | Other services | 2025 |
| Ship Inn Piel Island Limited | Hospitality | 2022 |
| Shokari Ltd | Administrative & support | 2017 |
| Signal Film & Media Limited | Information & communication | 2008 |
| Signal Films Limited | Information & communication | 2007 |
| Signature Property & Lettings Limited | Real estate | 2023 |
| Sikandar PVT Ltd | Health & social care | 2025 |
| Simba Freight Ltd | Transport & logistics | 2019 |
| SIR Woofchester's Ltd | Manufacturing | 2015 |
| Sizzle in Barrow Ltd | Hospitality | 2020 |
| SJ Fabrications (Liverpool) Limited | Manufacturing | 2003 |
| SJL Design Consultants Limited | Professional & scientific | 2004 |
| SJS Gastech Ltd | Construction | 2019 |
| Skillfinder Ltd | Professional & scientific | 2026 |
| Skills Shop Holdings Limited | Real estate | 2026 |
| Skitveen Limited | Transport & logistics | 2014 |
| SKM Engineering Management Ltd | Professional & scientific | 2025 |
| SL Young Ltd | Professional & scientific | 2025 |
| Slater Street Corner Shop Limited | Wholesale & retail | 2022 |
| Slatstech Ltd | Construction | 2025 |
| Slice Clubhouse Ltd | Hospitality | 2025 |
| SMJ Enterprises Ltd | Extraterritorial | 2014 |
| Snapstyledeals Ltd | Wholesale & retail | 2025 |
| Soccer Minions Ltd | Education | 2020 |
| Social in Mind Ltd | Professional & scientific | 2024 |
| Software Emporium Limited | Information & communication | 2025 |
| Solar Energy Consultants Ltd | Professional & scientific | 2011 |
| Sollert Ltd | Information & communication | 2026 |
| Solution: People Ltd | Administrative & support | 2018 |
| Soly Property Barrow Ltd | Real estate | 2025 |
| Something Blue Bridal Boutique Ltd | Extraterritorial | 2024 |
| Sonoview Ultrasound Services Ltd | Health & social care | 2026 |
| South Coast Clearance Ltd | Water & waste | 2019 |
| South Cumbria Consultancy Ltd | Professional & scientific | 2023 |
| South Cumbria Multi-Academy Trust | Education | 2021 |
| South Cumbrian Properties Ltd | Real estate | 2019 |
| South Lakes Development NM Limited | Administrative & support | 2016 |
| South Lakes Game Exchange Ltd | Wholesale & retail | 2024 |
| South Lakes Holiday Homes Limited | Hospitality | 2021 |
| South Lakes Interiors Ltd | Wholesale & retail | 2019 |
| South Lakes Investments Ltd | Real estate | 2023 |
| South Lakes Motorhome Hire Ltd | Administrative & support | 2015 |
| South Lakes Rentals Limited | Real estate | 2023 |
| South Lakes Service & MOT Centre Limited | Wholesale & retail | 2019 |
| South Lakes Services Limited | Construction | 2021 |
| South Lakes Technical Services Limited | Administrative & support | 2012 |
| Southlakes Building & Renovations Ltd | Construction | 2015 |
| SP Global Products Limited | Wholesale & retail | 2018 |
| SPARK10 Limited | Financial services | 2015 |
| Sparrow Engineering Limited | Professional & scientific | 2022 |
| Speed of Sound Limited | Real estate | 2003 |
| Spicy Knights 2 Ltd | Hospitality | 2021 |
| Spud Time Limited | Hospitality | 2025 |
| Square PEG Construction Ltd | Construction | 2015 |
| SRB Offshore, Subsea & Renewables Ltd | Professional & scientific | 2012 |
| ST. Andrews Engineering (Barrow-In-Furness) Limited | Manufacturing | 1974 |
| Staffordshire Lofts Ltd | Construction | 2021 |
| Star Pizza Darlington Ltd | Hospitality | 2018 |
| Staveley Spar Limited | Wholesale & retail | 2001 |