| Strategic Homes Ltd | Real estate | 2016 |
| Strathmore (Barnstaple) Management Company Limited | Real estate | 2016 |
| Studio Kind. Community Interest Company | Arts & recreation | 2020 |
| Studio Tally Ltd | Wholesale & retail | 2026 |
| Styg Rail Ltd | Professional & scientific | 2023 |
| Subio Services Ltd | Information & communication | 2021 |
| Succession Research Limited | Administrative & support | 2013 |
| Sumaqconsulting Ltd | Professional & scientific | 2025 |
| Sumbreeze Limited | Real estate | 2018 |
| Summit Property Trading Ltd | Real estate | 2024 |
| Sumners & SON Limited | Construction | 2002 |
| Sunny UP Ltd. | Wholesale & retail | 2014 |
| Sunrise Diversity | Education | 2013 |
| Sunrise Property Investments & GAS Maintenance Ltd | Real estate | 2024 |
| Super Sick Records Ltd | Construction | 2019 |
| Supernova Creative Solutions Limited | Information & communication | 2010 |
| Superstructables Limited | Construction | 2014 |
| Supported Accommodation Solutions Limited | Administrative & support | 2025 |
| Sure Train Ltd | Professional & scientific | 2021 |
| Suresafe Electrics Limited | Construction | 2004 |
| Surf South West Limited | Arts & recreation | 2001 |
| Surviving Abuse Northern Devon CIC | Health & social care | 2016 |
| Sussex Holdings (SW) Ltd | Financial services | 2025 |
| SW Portable Buildings Ltd | Manufacturing | 2015 |
| SW Skinny | Other services | 2022 |
| Swanmoor Limited | Professional & scientific | 2016 |
| Swannings 25 Limited | Construction | 2025 |
| Swift Accounting & Bookkeeping Services Ltd | Professional & scientific | 2020 |
| SWM & Waste Recycling Limited | Water & waste | 2002 |
| Sxey Limited | Wholesale & retail | 2013 |
| Sylmas Limited | Administrative & support | 1997 |
| Syntech Services Limited | Information & communication | 2003 |
| Syphonic Services Limited | Construction | 2001 |
| T & D Childcare Ltd | Health & social care | 2016 |
| T and B Rentals Limited | Real estate | 2017 |
| T F Electrical Limited | Construction | 2003 |
| T.L.C. Steam & Pressure Cleaning Services Limited | Other services | 2012 |
| T.Lynch & Sons Limited | Construction | 1950 |
| Tadworthy LLP | | 2017 |
| Talking Squid Limited | Real estate | 2013 |
| Talking Tax Ltd | Professional & scientific | 2015 |
| Tallyns Limited | Real estate | 2023 |
| Tanlion Limited | Real estate | 1977 |
| Tapas at Bude Ltd | Hospitality | 2023 |
| Taplow Investments Limited | Real estate | 1954 |
| Taracebel Limited | Manufacturing | 2025 |
| Target Devon CIC | Education | 2022 |
| Tarka Accounts Limited | Professional & scientific | 2023 |
| Tarka Care Ltd. | Health & social care | 2011 |
| Tarka Country Trust | Administrative & support | 1999 |
| Tarka Digital Ltd | Professional & scientific | 2023 |
| Tarka Drivers Ltd | Transport & logistics | 2015 |
| Tarka Home Improvements Limited | Construction | 2003 |
| Tarka Learning Partnership | Education | 2011 |
| Tarka Radio | Information & communication | 2000 |
| Tarka School of Gymnastics N. Devon Ltd | Administrative & support | 2017 |
| Tarka Tech Limited | Manufacturing | 2008 |
| Tarka Trax Limited | Wholesale & retail | 2018 |
| Tarka Trees Ltd | Extraterritorial | 2026 |
| Tarkax Safeharbour Ltd | Administrative & support | 2026 |
| Tattiscombe Farm Limited | Hospitality | 2022 |
| TAW and Torridge Tree Services Ltd | Administrative & support | 2014 |
| TAW Flooring (SW) Ltd | Construction | 2023 |
| TAW Insurance Solutions Ltd | Financial services | 2013 |
| TAW Pharma Limited | Professional & scientific | 2020 |
| TAW Roofing Ltd | Construction | 2023 |
| TAW Tech Limited | Manufacturing | 2009 |
| TAW Valley Contractors Limited | Agriculture & fishing | 1978 |
| TAW Valley Farming Limited | Extraterritorial | 2013 |
| TAW Valley Leisure Limited | Extraterritorial | 2022 |
| TAW Wharf Estate Management Company Limited | Real estate | 2019 |
| TAW Wharf Leasehold Management Company Limited | Real estate | 2019 |
| TAW Windows Limited | Manufacturing | 2012 |
| Tawsa Ltd | Administrative & support | 2006 |
| Tayforce Limited | Professional & scientific | 1998 |
| Taylor Made Alarms Ltd | Construction | 2025 |
| Taylored Campervan Conversions Ltd | Wholesale & retail | 2017 |
| Taylored Campervan Service Centre Ltd | Wholesale & retail | 2025 |
| Taylored Campervans Ltd | Wholesale & retail | 2019 |
| TCI (GB) Ltd | Construction | 2006 |
| Tea by the TAW Limited | Hospitality | 2024 |
| Teacher LED Tutoring Limited | Extraterritorial | 2020 |
| Team Multi-Academy Trust | Education | 2012 |
| Team Treat Ltd | Information & communication | 2026 |
| Tech Express (UK) Limited | Wholesale & retail | 2013 |
| Techsofts International Limited | Information & communication | 2019 |
| TED Humble Smith Photography Limited | Professional & scientific | 2007 |
| Teminite Ltd | Information & communication | 2020 |
| Terrycaseyconsult Ltd | Professional & scientific | 2023 |
| Tersys Limited | Information & communication | 2009 |
| That Wellness Place Ltd | Wholesale & retail | 2023 |
| THE Accounting Company (SW) Ltd | Professional & scientific | 2010 |
| THE Barley MOW Ltd | Hospitality | 2024 |
| THE Barnstaple Corner House Limited | Hospitality | 2010 |
| THE Barnstaple Ganges Limited | Hospitality | 2018 |
| THE Beach HUT Croyde Ltd | Wholesale & retail | 2019 |
| THE Beauty Haven Devon Ltd | Other services | 2024 |
| THE Bigger Image Ltd | Manufacturing | 2018 |
| THE Binge Box Ltd | Hospitality | 2021 |
| THE Bound Collective Ltd | Other services | 2025 |