| Rupert Golby Limited | Administrative & support | 2010 |
| Rupi Ltd | Wholesale & retail | 2020 |
| Rural Care Limited | Health & social care | 2004 |
| Rushoak Limited | Professional & scientific | 1977 |
| Russet and Sage Ltd | Construction | 2022 |
| Russian Translations Limited | Professional & scientific | 2004 |
| RVY Solutions Ltd | Wholesale & retail | 2023 |
| Ryokou Automotive Ltd | Professional & scientific | 2021 |
| RYP Trading Ltd | Professional & scientific | 2022 |
| S & R Property Investment Limited | Households | 2020 |
| S Cameron Mechtech Ltd | Professional & scientific | 2023 |
| S E G Projects Ltd | Professional & scientific | 2008 |
| S K Thorne Ltd | Professional & scientific | 2010 |
| S P Valentine (Electrical Design, Installation and Maintenance) Limited | Energy | 2012 |
| S R Crockford Ltd | Real estate | 2025 |
| S V P Donovan Ltd | Construction | 2006 |
| S Wright Electrical Limited | Construction | 2023 |
| S&A Home Build Ltd | Construction | 2018 |
| S&F Global Services Ltd | Construction | 2022 |
| S&F Stonework and Construction Ltd | Construction | 2025 |
| S&R Business Limited | Wholesale & retail | 2012 |
| S&S Read Limited | Professional & scientific | 2011 |
| S&W Building Contractors Ltd | Construction | 2024 |
| S'Loreia Ltd | Wholesale & retail | 2019 |
| S-Branch Ltd | Information & communication | 2018 |
| S. Marron Developments Ltd | Construction | 2014 |
| S. R. Coates Plumbing & Heating Limited | Construction | 2007 |
| S.A & M.N CHD Property Ltd | Real estate | 2017 |
| S.A. England and Sons Removals Ltd | Transport & logistics | 2026 |
| S.E.B Healthcare Consultancy Ltd | Professional & scientific | 2012 |
| S.J. Leonard & Daughters Building Contractor Limited | Construction | 2013 |
| S.L.B.K Property Ltd | Real estate | 2025 |
| S.M.D Brickwork Ltd | Construction | 2018 |
| S.M.S. Window Cleaning Ltd | Administrative & support | 2021 |
| S4LABOUR Limited | Information & communication | 2011 |
| S4PAY Limited | Information & communication | 2025 |
| S7ONE Ltd | Wholesale & retail | 2013 |
| Sabnam RAI DEE Limited | Manufacturing | 2025 |
| Sabrina Rose Property Ltd | Real estate | 2022 |
| Sabrina Yasmina Limited | Construction | 2023 |
| Sabrinasnails Ltd | Other services | 2025 |
| Sacred Sunnah | Education | 2025 |
| Saddlery Brands International UK Limited | Manufacturing | 2016 |
| Sadiq Residence Ltd | Real estate | 2016 |
| Safar Clothing Ltd | Wholesale & retail | 2024 |
| Safe and Sound Scaffolding Limited | Construction | 2022 |
| Safe-Watch Online Ltd | Information & communication | 2018 |
| Saffron Close (Banbury) Management Company Limited | Households | 2008 |
| Sake 1814 Ltd | Financial services | 2022 |
| Salamander Services Ltd | Financial services | 2022 |
| Salisbury Partnership Limited | Real estate | 2024 |
| Salix Technology Services Ltd | Information & communication | 2013 |
| Salsa Scheme Limited | Other services | 2020 |
| Salsa Technologies Limited | Professional & scientific | 2006 |
| Salt and Summit Travel Ltd | Administrative & support | 2026 |
| Salt Bros Property Ltd | Real estate | 2024 |
| Saltway Construction Ltd | Construction | 2011 |
| Salty Property Group Limited | Real estate | 2022 |
| Samaguru Productions Limited | Arts & recreation | 1974 |
| Same Same Just Different Ltd | Hospitality | 2019 |
| Sandaris Limited | Administrative & support | 2009 |
| Sanders GD Building Limited | Construction | 2023 |
| Sandford Projects Ltd | Other services | 2025 |
| Sandstone Porcelain Imports Ltd | Wholesale & retail | 2022 |
| Sandy Lane Ventures Limited | Hospitality | 2000 |
| Sapphire Browne Ltd | Administrative & support | 2018 |
| Sapphire Business Services (Banbury) Limited | Professional & scientific | 2010 |
| Sapphire Sewing Ltd | Manufacturing | 2021 |
| Sara & Kami Ltd | Wholesale & retail | 2024 |
| Sarah KAY Limited | Arts & recreation | 2016 |
| Sarah Wall Ltd | Professional & scientific | 2019 |
| Sararin Limited | Hospitality | 2014 |
| Sarnie 67 Catering Ltd | Hospitality | 2022 |
| Sass & Belle Limited | Professional & scientific | 2023 |
| Sassify Zine Creations Ltd | Professional & scientific | 2024 |
| Saturn Cycles Ltd | Wholesale & retail | 2025 |
| Saturnfive Consulting Limited | Professional & scientific | 2018 |
| Sauce Direct Company Limited | Extraterritorial | 2016 |
| Savafut Original Limited | Transport & logistics | 2017 |
| Savins Holdings Limited | Real estate | 2018 |
| Savour Catering Ltd | Hospitality | 2023 |
| Saxmundham Ventures Limited | Extraterritorial | 2025 |
| SB Carpentry Services Ltd | Construction | 2021 |
| SB Editions Limited | Hospitality | 2017 |
| SB North East Limited | Hospitality | 2015 |
| SB Realty Limited | Hospitality | 2013 |
| Scalistix Ltd | Information & communication | 2022 |
| Scarab Medical Innovations Limited | Manufacturing | 2025 |
| Schon Executive Cars Limited | Other services | 2017 |
| Schoolsays Ltd | Information & communication | 2024 |
| Scientific Survey & Location Limited | | 1966 |
| Scigo Ltd | Construction | 2023 |
| SCOOTER216 Limited | Arts & recreation | 2021 |
| Scotchegg Media Limited | Information & communication | 2012 |
| Scott Munro Carpentry Ltd | Manufacturing | 2023 |
| Scott Munro Property Ltd | Construction | 2023 |
| Scramm Live Escape Rooms ( Banbury) Ltd | Arts & recreation | 2023 |
| Scyllabus Limited | Professional & scientific | 2007 |
| SDB Designs Limited | Administrative & support | 2012 |
| SDD Deliveries Ltd | Transport & logistics | 2025 |