| David Cooper Consultancy Limited | Administrative & support | 2018 |
| David Couch Professional Services Limited | Information & communication | 2011 |
| David Green Decorating Limited | Construction | 2007 |
| David Hayward Carpentry and Construction Limited | Construction | 2023 |
| David Hunt Lighting Limited | Manufacturing | 1972 |
| David Mumford Butchers Limited | Wholesale & retail | 2004 |
| David TEW Limited | Other services | 1963 |
| David Walls Consulting Limited | Professional & scientific | 2013 |
| Davidson Heating & Plumbing Limited | Construction | 2015 |
| Davis WU Property Limited | Real estate | 2025 |
| Dawn & Lindsay Ltd | Administrative & support | 2014 |
| DB Antiques Limited | Wholesale & retail | 2014 |
| DB Two Construction Limited | Construction | 2017 |
| DBS Capital Holdings Ltd | Construction | 2023 |
| DBS Property Limited | Real estate | 2015 |
| DC Associates (GB) Ltd | Professional & scientific | 2005 |
| DC on Road Ltd | Transport & logistics | 2024 |
| Dcge Services Limited | Administrative & support | 2011 |
| DCS Central Limited | Extraterritorial | 1999 |
| DCS Europe Limited | Extraterritorial | 2013 |
| DCS Group (UK) Limited | Manufacturing | 1991 |
| DDL Electrical Limited | Construction | 2024 |
| DE LA PAK Limited | Professional & scientific | 2004 |
| DE Novo Pharmaceuticals Limited | Professional & scientific | 1999 |
| De-Ark Ltd | Wholesale & retail | 2022 |
| Dead Poet Ltd | Information & communication | 2020 |
| Deakin Creative Design Ltd | Professional & scientific | 2019 |
| Debbie Anna Jones Limited | Professional & scientific | 2015 |
| Decarbonise Global Ltd | Financial services | 2023 |
| Decent Food Ltd | Wholesale & retail | 2020 |
| Decorfix Ltd | Construction | 2014 |
| Deddington Environment Network CIC | Professional & scientific | 2020 |
| Deddington Farmers' Market CIC | Wholesale & retail | 2015 |
| Deddington Housing Association Limited | Hospitality | 2023 |
| Deddington Media CIC | Information & communication | 2012 |
| Deddington Rocks Festival CIC | Arts & recreation | 2025 |
| Deddington Windmill Community Centre Ltd | Professional & scientific | 2003 |
| Deea's Homes Ltd | Hospitality | 2023 |
| Deeano's Garage Ltd | Wholesale & retail | 2026 |
| Deea’S Property Group Ltd | Real estate | 2025 |
| Deeone Healthcare Ltd | Health & social care | 2021 |
| Deep Dungeon Ltd | Wholesale & retail | 2021 |
| Deep Scoring Ltd | Information & communication | 2017 |
| Defiant Group Limited | Manufacturing | 2024 |
| Degrene Limited | Construction | 2024 |
| DEI Skincare Ltd | Manufacturing | 2020 |
| Deir Martin Ltd | Arts & recreation | 2022 |
| Delara Retail Limited | Wholesale & retail | 2024 |
| Delia Continental Food Ltd | Wholesale & retail | 2011 |
| Delicious Oxon Ltd | Wholesale & retail | 2018 |
| Deliciously Digital Limited | Information & communication | 2013 |
| Delphian Gallery Ltd | Professional & scientific | 2017 |
| Delphic Property Management Company Limited | Real estate | 2022 |
| Delrob Group Ltd | Financial services | 2019 |
| Delta Bravo Limited | Construction | 2007 |
| Delux Property Ltd | Real estate | 2025 |
| Dematic Group Limited | Professional & scientific | 2015 |
| Dematic Limited | Manufacturing | 2006 |
| Denham Wealth Management LLP | | 2013 |
| Denison Holdings Ltd | Financial services | 2023 |
| Denison Properties (2023) Limited | Real estate | 2023 |
| Denison Properties Limited | Real estate | 2020 |
| Dentibond Ltd | Health & social care | 2022 |
| Deol Investments Ltd | Real estate | 2024 |
| DEP Property Investments Limited | Real estate | 2026 |
| Derek R Weale LP | | 2017 |
| Design & Technology Associated Services Limited | Education | 1997 |
| Design Innovative Technologies Ltd. | Manufacturing | 2011 |
| Desserts by Kebabish Limited | Manufacturing | 2020 |
| Detail Property Ltd | Real estate | 2025 |
| Detectorists World Ltd | Information & communication | 2023 |
| Detonator Publishing Ltd | Information & communication | 2022 |
| Development UK Group Ltd | Real estate | 2021 |
| Devtek Ltd | Information & communication | 2020 |
| DFS Food Consulting Ltd | Professional & scientific | 2016 |
| DHB Bodycraft Limited | Administrative & support | 2010 |
| DHB Limited | Administrative & support | 2008 |
| DHB Live Ltd | Extraterritorial | 2020 |
| Dhesi Property Holdings Ltd | Real estate | 2020 |
| Dhwanee Supermarket Ltd | Wholesale & retail | 2020 |
| Diagnostic Path Solutions Limited | Information & communication | 2014 |
| Dial a BIN Limited | Water & waste | 2014 |
| Diamond Interiors Limited | Manufacturing | 1989 |
| Diamond's Food and Catering Services Limited | Hospitality | 2025 |
| Digi NUT Limited | Information & communication | 2006 |
| Digital Aerospace (Europe) Ltd | Manufacturing | 2022 |
| Digital and Disruptive Connections Ltd | Administrative & support | 2014 |
| Digital Peak Limited | Information & communication | 2014 |
| Digital Takumi Ltd | Information & communication | 2019 |
| Digital Video Productions Limited | Information & communication | 1999 |
| Digital-Webdev Ltd | Information & communication | 2021 |
| Digivation Ltd | Information & communication | 2015 |
| Dima Fine Food Ltd | Hospitality | 2020 |
| Dimarc Limited | Wholesale & retail | 2018 |
| Dineks Ltd | Wholesale & retail | 2018 |
| Dinoiu Ltd | Transport & logistics | 2024 |
| Dior’S Bakery and Coffee Ltd | Hospitality | 2025 |
| Direct Insight Limited | Wholesale & retail | 1992 |
| Direct Pizza Kebab Ltd | Hospitality | 2019 |
| Dirigo Investments Limited | Information & communication | 2020 |