| Sultania Essential Aromas Ltd | Manufacturing | 2025 |
| Sumando Ltd | Construction | 2022 |
| Sumando UK IPP Ltd | Construction | 2023 |
| Sumitomo (SHI) Demag Plastics Machinery (UK) Limited | Wholesale & retail | 1974 |
| Summer Sunday Ltd | Professional & scientific | 2025 |
| Summit Trilogy Ltd | Real estate | 2026 |
| Summit With Mark Ltd | Professional & scientific | 2026 |
| Sunderland (Storage) Limited | Transport & logistics | 1966 |
| Sunderland(Herts.)Hauliers Limited | Transport & logistics | 1954 |
| Sunflower Health Limited | Administrative & support | 2024 |
| Sunnah Harvest Ltd | Wholesale & retail | 2024 |
| Sunnex (U.K.) Limited | Extraterritorial | 1979 |
| Sunnica Energy Farm Limited | Extraterritorial | 2018 |
| Sunnica Energy Limited | Extraterritorial | 2018 |
| Sunnica Farm Limited | Extraterritorial | 2018 |
| Sunnica Limited | Construction | 2013 |
| Sunray Stores Ltd | Wholesale & retail | 2021 |
| Super Bargain Deals Limited | Wholesale & retail | 2025 |
| Super Leggera Limited | Wholesale & retail | 2003 |
| Super Luxe Events Ltd | Extraterritorial | 2015 |
| Super Serious Coaching Ltd | Education | 2024 |
| Supervision VP Ltd | Information & communication | 2025 |
| Supply Experts Limited | Administrative & support | 2013 |
| Support Consulting Ltd | Professional & scientific | 2020 |
| Support in the Community Limited | Health & social care | 2017 |
| Supreme Clean Domestic and Commercial Cleaning Services Ltd | Administrative & support | 2022 |
| Supreme Finish Carpentry & Building Ltd | Manufacturing | 2023 |
| SUR Chocolates Ltd | Manufacturing | 2021 |
| Surab Limited | Construction | 1995 |
| SURE2DOOR Limited | Transport & logistics | 2012 |
| Suresh Homes Ltd | Real estate | 2020 |
| Surface Science Limited | Financial services | 2016 |
| Surge Consultancy Ltd | Information & communication | 2012 |
| Surge SBT (PVT) Ltd | Wholesale & retail | 2024 |
| Surrey Joinery & Construction Ltd | Administrative & support | 2023 |
| Suryakala Bonagiri Limited | Information & communication | 2010 |
| Sustentus Ltd | Professional & scientific | 2023 |
| Suzette M E Curtis Ltd | Professional & scientific | 2026 |
| Suzy Elizabeth Photography Ltd | Professional & scientific | 2018 |
| SV Systems & Services Ltd | Hospitality | 2026 |
| SVB Technologies Ltd | Information & communication | 2023 |
| SVK UK Transfers Ltd | Transport & logistics | 2025 |
| SVN Applied Technologies Limited | Administrative & support | 2024 |
| SVP Infosystems Ltd | Information & communication | 2021 |
| SVW Advisors Limited | Administrative & support | 2019 |
| SW Business Solutions Limited | Administrative & support | 2010 |
| SW Lane Limited | Wholesale & retail | 2022 |
| Swadling Consulting Limited | Professional & scientific | 2025 |
| Swaffham Coffee House Ltd | Hospitality | 2026 |
| Swansong Productions Ltd | Information & communication | 2022 |
| Swash Ltd | Administrative & support | 2026 |
| Swastik Holdings Limited | Real estate | 2019 |
| Swastik Investments Limited | Real estate | 2019 |
| Sweeney Property Investments Ltd | Real estate | 2023 |
| Sweet Maison Limited | Real estate | 2016 |
| Sweet-Bites Limited | Hospitality | 2011 |
| Sweetman Buttons Limited | Professional & scientific | 2017 |
| Sweetman Yale Limited | Other services | 2021 |
| Sweetriangle Limited | Wholesale & retail | 2021 |
| SWH Consulting Services Ltd | Administrative & support | 2015 |
| Swift Business Support Ltd | Information & communication | 2024 |
| Swift Curio Ltd | Wholesale & retail | 2025 |
| Swift Performance Ltd | Wholesale & retail | 2007 |
| Swiftstar Limited | Real estate | 2015 |
| Swirlx Ltd | Wholesale & retail | 2025 |
| Swooshfx Ltd | Information & communication | 2022 |
| SWR Dell Consultancy Limited | Professional & scientific | 2018 |
| Syber Solutions Ltd. | Professional & scientific | 2017 |
| Sybo Properties Limited | Real estate | 2020 |
| Syient Ltd | Information & communication | 2014 |
| Sylvester Financial Planning Ltd | Professional & scientific | 2026 |
| Sylvie Noel Ltd | Manufacturing | 2009 |
| Sylwia Erasmus Ltd | Health & social care | 2018 |
| Symb Limited | Information & communication | 1998 |
| Symola Properties Limited | Professional & scientific | 2007 |
| Syncro Investments Limited | Professional & scientific | 1995 |
| Syscally Limited | Construction | 2020 |
| Szaki Limited | Construction | 2025 |
| T & F Motors Limited | Wholesale & retail | 2012 |
| T & J Curiious Limited | Wholesale & retail | 2023 |
| T & L Authentic Caribbean Delicacies Ltd | Hospitality | 2026 |
| T Drop Couriers Limited | Transport & logistics | 2019 |
| T Gibbs Group Ltd | Administrative & support | 2025 |
| T Gibson Properties Limited | Real estate | 2021 |
| T L Media Limited | Information & communication | 2010 |
| T M Recruitment Limited | Administrative & support | 2004 |
| T T Commercial Trading Ltd | Wholesale & retail | 2006 |
| T Weir Dental Practice Limited | Health & social care | 2011 |
| T&D Electrical (Holdings) Ltd | Financial services | 2023 |
| T&D Electrical (Southern) Ltd. | Construction | 2017 |
| T&D Electrical Small Works Ltd | Construction | 2021 |
| T&D Enterprise Limited | Health & social care | 2019 |
| T&D Home Solutions Ltd | Other services | 2024 |
| T&M Jones Properties Ltd | Real estate | 2020 |
| T&M Prime Estates Ltd | Real estate | 2023 |
| T. Clubb & SON Limited | Construction | 2001 |
| T. Kenneth Property Management Ltd | Real estate | 2026 |
| T. M. Milward Limited | Health & social care | 2009 |
| T. S. Walsh Limited | Administrative & support | 1981 |
| T.B.Hse.Services Ltd | Extraterritorial | 2022 |