| Clobel Limited | Other services | 2023 |
| Clock Tower Cafe (Sidmouth) Limited | Hospitality | 2003 |
| Closer to Customers Limited | Professional & scientific | 2001 |
| Cloud Flooring Ltd | Construction | 2023 |
| Cloudwheels Limited | Information & communication | 2015 |
| Clover & Bay Ltd | Wholesale & retail | 2025 |
| CLS Logistics Ltd | Transport & logistics | 2021 |
| CMC Property Services South West Ltd | Construction | 2021 |
| Coast Watersports Ltd | Extraterritorial | 2013 |
| Coastline Creative Limited | Professional & scientific | 2012 |
| Cobb Lodge Limited | Households | 2020 |
| Coffee Factory Ltd | Manufacturing | 2008 |
| Coleberd Consulting Ltd | Professional & scientific | 2015 |
| Colway Gate Ltd | Hospitality | 2020 |
| Colyton Takeaway Limited | Hospitality | 2014 |
| Comfort Linen Ltd | Other services | 2018 |
| Complete Meats Limited | Wholesale & retail | 2014 |
| Construction Calculator Ltd | Information & communication | 2019 |
| Contactlearn Limited | Professional & scientific | 2002 |
| Coot's Coffee Ltd | Hospitality | 2025 |
| Cornerstone Auto TEC Limited | Wholesale & retail | 2025 |
| Costume World (UK) Limited | Manufacturing | 2011 |
| Country Memorials Limited | Construction | 2019 |
| Country Motors Limited | Wholesale & retail | 2007 |
| Court's Gardening Services Ltd | Administrative & support | 2025 |
| Courtesy Care Limited | Health & social care | 2007 |
| CR Personal Security Ltd | Administrative & support | 2025 |
| Craft Creative Group (Devon) Ltd | Manufacturing | 2025 |
| Craft Creative Group Ltd | Hospitality | 2022 |
| Craft Draft Ltd | Wholesale & retail | 2022 |
| Creative Lemon Ltd | Information & communication | 2014 |
| Cressdale Limited | Real estate | 2000 |
| Crown Key Trading Limited | Financial services | 2026 |
| CS Equine Modelling Agency Ltd | Administrative & support | 2022 |
| CST Joinery Limited | Manufacturing | 2012 |
| Current Energies Ltd | Energy | 2025 |
| Current Energy Ltd | Energy | 2025 |
| Current Renewables Ltd | Construction | 2024 |
| Curvegold Investments Ltd | Real estate | 2010 |
| Cwmo Ltd | Professional & scientific | 2023 |
| D H Hospitality Ltd | Hospitality | 2019 |
| D K Taylor Financial Services Ltd | Financial services | 2026 |
| D&Tn Ltd | Professional & scientific | 2020 |
| Dairy Farm Services S/West Limited | Administrative & support | 2008 |
| Daisy Blue Cafe Ltd | Hospitality | 2026 |
| Daisy Blue Delights Ltd | Hospitality | 2021 |
| Dalwood Hill Farm Limited | Real estate | 2017 |
| Dalwood Vineyard Limited | Agriculture & fishing | 2024 |
| Dare Farms Limited | Agriculture & fishing | 2010 |
| Darkplace Brewery Limited | Manufacturing | 2016 |
| Data Control Applications Limited | Information & communication | 2003 |
| Datacore Property Limited | Real estate | 2025 |
| Davies Macadam Ltd | Construction | 2023 |
| Dean Bonetta Limited | Construction | 2014 |
| Debbie Hunt Design Ltd | Professional & scientific | 2014 |
| Delapole Court Management Company Limited | Professional & scientific | 2007 |
| Delta Plumbing&Heating Ltd | Construction | 2019 |
| Dena AFS UK Ltd | Wholesale & retail | 2023 |
| Design Aspects Limited | Professional & scientific | 2003 |
| Devon and Dorset Holidays Ltd | Hospitality | 2014 |
| Devon Curry House Ltd | Hospitality | 2024 |
| Devon in a Box Ltd | Wholesale & retail | 2022 |
| Devon IT Ltd | Other services | 2020 |
| Devon Weaving Mills Limited | Manufacturing | 2025 |
| Dicoda Services Ltd | Professional & scientific | 1986 |
| Direct Tax Limited | Professional & scientific | 2004 |
| Discover Destinations Limited | Administrative & support | 2024 |
| District Heating Installations Limited | Construction | 2016 |
| Dlrz Limited | Transport & logistics | 2018 |
| DMF Pilot Training Ltd | Professional & scientific | 2024 |
| DO IT Great Limited | Professional & scientific | 2021 |
| Dog in a Box Limited | Wholesale & retail | 2019 |
| Dogsrlife Ltd | Other services | 2021 |
| Dollyhotdogs Limited | Wholesale & retail | 2021 |
| Doodle Soup Ltd | Professional & scientific | 2015 |
| Dorset House Lyme LLP | | 2014 |
| Dpsnvq Limited | Professional & scientific | 2020 |
| Driftwood Tree Hospitality Services Ltd | Hospitality | 2023 |
| Drjj Investment Limited | Real estate | 2024 |
| DT Construction (SW) Limited | Construction | 2017 |
| Dvrf Limited | Professional & scientific | 2012 |
| Dynamic Landscaping SW Ltd | Administrative & support | 2024 |
| E a Brown & Co Limited | Manufacturing | 2002 |
| E.TC3 Limited | Administrative & support | 2002 |
| East Devon Sports Therapy - Rehabilitation & Performance Centre Limited | Health & social care | 2020 |
| East Devon Sports Therapy Limited | Extraterritorial | 2015 |
| Ebrasives Limited | Wholesale & retail | 2018 |
| Eco Pathways Community Interest Company | Professional & scientific | 2023 |
| Ecolocker Limited | Information & communication | 2012 |
| Eddierax Ltd | Manufacturing | 2014 |
| Electives for Evidence Ltd | Administrative & support | 2023 |
| Ellen D Coomber Limited | Professional & scientific | 2019 |
| Ellen Villier Limited | Wholesale & retail | 2013 |
| Empire Build London Limited | Manufacturing | 2011 |
| Euro Fibre Ltd | Administrative & support | 2022 |
| Euroc Limited | Professional & scientific | 2018 |
| European Holiday Home Association Limited | Other services | 2013 |
| EX Electrics Ltd | Construction | 2020 |
| Exeter Otter Wheelchair Basketball Club CIC | Education | 2025 |
| Exigo Service Solutions Ltd | Transport & logistics | 2013 |