| Rhys Brown Wind Ltd | Professional & scientific | 2026 |
| Richard SIM Ltd | Manufacturing | 2017 |
| RJF Building Systems Ltd | Real estate | 2018 |
| RJF Construction (NE) Limited | Construction | 2011 |
| RKB Offshore Services Limited | Professional & scientific | 2010 |
| Rljp Ltd | Other services | 2026 |
| Roberts Beauty Ltd | Other services | 2025 |
| Roberts Residential Estates Ltd | Real estate | 2025 |
| Roberts Wealth & Sons Ltd | Professional & scientific | 2026 |
| Rock Paper Productions Limited | Information & communication | 2021 |
| Rollo’S Pizzeria Limited | Hospitality | 2025 |
| Roofsol N. E. Limited | Construction | 2025 |
| Rosemarie House Limited | Real estate | 2022 |
| Rosewood Virtual Academy Limited | Education | 2025 |
| RTO Projects Ltd | Professional & scientific | 2023 |
| S & J Engineering and Fabrication Services Ltd | Professional & scientific | 2021 |
| S & S Stevenson Homes Ltd | Construction | 2025 |
| S D OIL and GAS Limited | Professional & scientific | 2025 |
| S D Service Solutions Ltd | Mining & quarrying | 2016 |
| S D V J Ltd | Wholesale & retail | 2025 |
| S K Packaging Limited | Other services | 2004 |
| S&J Floor Sanding Ltd | Construction | 2022 |
| S&J Properties NE Limited | Real estate | 2024 |
| S&W Stores Limited | Wholesale & retail | 2025 |
| S. J. Harmison Limited | Arts & recreation | 2004 |
| S3NVENTUS Ltd | Professional & scientific | 2021 |
| Sabai Warrior Fitness Ltd | Arts & recreation | 2021 |
| Sahib Property Ltd | Real estate | 2025 |
| Sailaway Seaglass Ltd | Manufacturing | 2023 |
| SAL Access Ltd | Extraterritorial | 2018 |
| Sallow Pightle Ltd | Professional & scientific | 2020 |
| Salon R Ltd | Other services | 2025 |
| Salon R Management Ltd | Real estate | 2025 |
| Samba Siva Limited | Hospitality | 2026 |
| Sarah Lowes Consulting Ltd | Professional & scientific | 2016 |
| SAW YER Trees Ltd | Real estate | 2022 |
| Scotstyke Consulting Limited | Professional & scientific | 2013 |
| Scott and Neave Plumbing and Heating Ltd | Construction | 2019 |
| Scott and Sons Pallets Ltd | Wholesale & retail | 2016 |
| Scotts Making Waves Ltd | Arts & recreation | 2013 |
| SDG Logistic Solutions (N/E) Ltd | Transport & logistics | 2025 |
| Seaton Manor Engineering Services Ltd | Professional & scientific | 2020 |
| Seaton Point Caravan Site Limited | Real estate | 2019 |
| Secure IT Group Ltd | Information & communication | 2020 |
| Selkirk Welding Services Limited | Mining & quarrying | 2016 |
| SF Fried Chicken Ltd | Hospitality | 2026 |
| Shareef Marts Trades Limited | Wholesale & retail | 2025 |
| Sharon Makomborero Limited | Health & social care | 2023 |
| Site and Field Services Limited | Manufacturing | 2004 |
| SIX Degrees Strategy Limited | Professional & scientific | 2026 |
| SJW Ttmbc Ltd | Construction | 2026 |
| SKC Design UK Limited | Professional & scientific | 2024 |
| SLW Holiday Lets Ltd | Hospitality | 2023 |
| Smallbiz Safety Setup Limited | Public administration | 2025 |
| Smart Choice Music Ltd | Wholesale & retail | 2011 |
| Sns-Merchworks Limited | Manufacturing | 2025 |
| Solar Shack Ltd | Manufacturing | 2021 |
| Sontara Ltd | Wholesale & retail | 2025 |
| Sorrento Ashington Ltd | Hospitality | 2014 |
| Soulbook Limited | Information & communication | 2024 |
| Southgate INT Ltd | Professional & scientific | 2024 |
| Sovereign Strategy Limited | Administrative & support | 1999 |
| Sovereign Sustainability and Development Ltd | Professional & scientific | 2017 |
| Sparc Engineering Services (North) Ltd | Other services | 2013 |
| Sparks Recycling Ltd Ltd | Water & waste | 2024 |
| Sphere Specialist Healthcare Ltd | Health & social care | 2021 |
| Spicy HUT Ashington Limited | Hospitality | 2024 |
| Springfield Accountancy Limited | Real estate | 2004 |
| SRH Build Ltd | Construction | 2019 |
| SRS Pipeline Services Ltd | Professional & scientific | 2023 |
| ST Helen's Gate (Longhorsley) Management Company Limited | Households | 2026 |
| STAR23 Barber Limited | Other services | 2023 |
| Station MOT Centre Ltd | Wholesale & retail | 2013 |
| Station Road Chippy (Ashington) Ltd | Hospitality | 2023 |
| Stone Water Estates Limited | Real estate | 2025 |
| Storie's Recycling Ltd | Water & waste | 2025 |
| Student-Centred Learning Limited | Education | 2025 |
| Sugarfayre Ltd. | Manufacturing | 1991 |
| Sukurat Holdings Ltd | Financial services | 2025 |
| Sunrise Total Services Ltd | Real estate | 2025 |
| Supreme Scaffold Solutions Ltd | Construction | 2025 |
| Sussex Ballistics Ltd | | 1981 |
| Sussex Caravan Centre East Properties Ltd | Financial services | 2018 |
| Sussex Caravan Centre Holdings Limited | Financial services | 2010 |
| Sussex Caravan Property Holdings Limited | Financial services | 2010 |
| SW Signature Builders Ltd | Construction | 2025 |
| Swan NE Properties Limited | Real estate | 2017 |
| Swedish Lifestyle Homes NO.1 Limited | Construction | 2015 |
| Swedish Lifestyle Homes NO.3 Limited | Construction | 2018 |
| Swift Office Solutions Direct Ltd | Real estate | 2025 |
| T Farrell Roofing and Building Limited | Administrative & support | 2010 |
| T262 Consulting Limited | Professional & scientific | 2023 |
| Table Manners Limited | Professional & scientific | 2013 |
| Tactifil Limited | Wholesale & retail | 2016 |
| Tanned & Juicy Ltd | Administrative & support | 2023 |
| Tartan Manor Limited | Wholesale & retail | 2013 |
| Taste Authentic Ltd | Hospitality | 2022 |
| Taylor Commissioning Services Ltd | Construction | 2024 |
| Taylors Hydrotherapy Centre Ltd | Wholesale & retail | 2021 |
| Tech Design Team (UK) Limited | Wholesale & retail | 2012 |