| Sansom Supplies Limited | Information & communication | 2016 |
| Santa Maria (Properties) Limited | Real estate | 1995 |
| Sapmaz Ltd | Hospitality | 2026 |
| Sapphire Lounge Kent Ltd | Hospitality | 2023 |
| SAR (UK) Limited | Manufacturing | 2014 |
| Sara's Office Services Limited | Administrative & support | 2019 |
| Sara's Virtual Office Solutions Ltd | Administrative & support | 2024 |
| Sarah Terry Support Ltd | Health & social care | 2022 |
| Saranya Consulting Limited | Information & communication | 2010 |
| Saranya Investing Ltd | Financial services | 2023 |
| Sargent Carpentry Services Limited | Construction | 2010 |
| Sargent Rigging Services Ltd | Information & communication | 2015 |
| Sargento Construction Ltd | Construction | 2018 |
| Sargun Convenience Stores Limited | Wholesale & retail | 2018 |
| Sargun Real Estates Limited | Real estate | 2023 |
| Sarla Limited | Administrative & support | 2015 |
| Sarman Ltd | Administrative & support | 2018 |
| Sarna Homes Ltd | Real estate | 2020 |
| Sarnia Tax Consulting Limited | Professional & scientific | 2020 |
| Sartorial Landscape Services Ltd | Administrative & support | 2025 |
| SAS Ashford Cafe Ltd | Hospitality | 2019 |
| Sasa Sisal Ltd | Wholesale & retail | 2025 |
| Sashas Prints Ltd | Manufacturing | 2024 |
| Satelles Limited | Professional & scientific | 2000 |
| Satis RM Ltd | Health & social care | 2022 |
| Savanna WPM Limited | Health & social care | 2020 |
| Save on Supplements Ltd | Wholesale & retail | 2014 |
| Save Water Limited | Manufacturing | 2010 |
| Savers Newsagent (Kennington) Limited | Wholesale & retail | 2013 |
| Savetime Transport Ltd | Transport & logistics | 2025 |
| Savihar Limited | Information & communication | 2018 |
| Savills Awnings Group Ltd | Other services | 2025 |
| Savin Food and Wine Ltd | Wholesale & retail | 2019 |
| Savina Beauty Limited | Other services | 2025 |
| SAW Holdings (Kent) Limited | Financial services | 2021 |
| SAW Joinery Limited | Manufacturing | 1995 |
| SAW Properties (Kent) Limited | Construction | 2021 |
| Sawdust Ltd | Manufacturing | 2020 |
| Sawmills Bespoke Furniture Limited | Manufacturing | 2012 |
| SAX Property Investments LLP | | 2023 |
| SAX Ventures Limited | Real estate | 2023 |
| Saxon Technology Ltd | Other services | 2017 |
| SB AUTOMOTIVE24 Ltd | Professional & scientific | 2026 |
| SB Third Limited | Financial services | 2024 |
| Sbal Limited | Other services | 2023 |
| SBC Brickwork Ltd | Construction | 2018 |
| SBG Removals & Services Ltd | Construction | 2026 |
| SBK (Managed) Events Limited | Professional & scientific | 2022 |
| SBK (UK) Limited | Administrative & support | 2005 |
| SBK Healthcare Limited | Extraterritorial | 2011 |
| SBK Sixteen Limited | Professional & scientific | 2014 |
| Sbrm Properties Limited | Real estate | 2016 |
| SBS Design UK Base Limited | Manufacturing | 2021 |
| SBS Research & Development England Ltd | Professional & scientific | 2021 |
| SBS Warp Ltd | Information & communication | 2012 |
| SC Luca Serv Ltd | Transport & logistics | 2021 |
| Scalderhurst Limited | Manufacturing | 1973 |
| Scalecloud Ltd | Information & communication | 2018 |
| Scallywags Children's Nursery (Staines) Ltd | Education | 2021 |
| Scandic Real Estate Limited | Real estate | 2016 |
| Scarfe Ltd | Information & communication | 2021 |
| Scarlett Financial Services Limited | Financial services | 2016 |
| Scarlett Homes (Kent) Limited | Real estate | 2015 |
| Scents in the Garden Ltd | Professional & scientific | 2023 |
| SCG Procurement Limited | Professional & scientific | 2011 |
| SCG Products Limited | Wholesale & retail | 2023 |
| School Bells T/A Uniforms and Beyond Ltd | Wholesale & retail | 2019 |
| Science for Athletes Ltd | Education | 2023 |
| Science to Business Limited | Professional & scientific | 2000 |
| Scintillo Limited | Professional & scientific | 2004 |
| Scissor CUT Ltd | Other services | 2025 |
| Scissors & Razor Ltd | Other services | 2020 |
| Sclb (Holdings) Limited | Real estate | 2024 |
| Scobech Ltd | Professional & scientific | 2020 |
| Scofield Health Limited | Health & social care | 2010 |
| Scorer Football Academy Ltd | Education | 2025 |
| Scotchtown Holdings Limited | Financial services | 2022 |
| Scott and Partners (South) Limited | Construction | 2006 |
| Scotter UK Logistics Ltd | Transport & logistics | 2022 |
| Scouting Talent Sports Agency Limited | Arts & recreation | 2024 |
| Scrapper Media Ltd | Information & communication | 2020 |
| Screen Scene (UK) Limited | Real estate | 2001 |
| Screen Scene Incorporated Ltd | Manufacturing | 2023 |
| Scrip Issue Limited | Information & communication | 2012 |
| SCS Storage Limited | Real estate | 2025 |
| SCT Exterior Cleaning Ltd | Administrative & support | 2026 |
| Sculpted by SL Limited | Other services | 2023 |
| Sculpture Solutions Limited | Other services | 2010 |
| Scylla Estates LLP | | 2025 |
| SD Electrical (South East) Limited | Extraterritorial | 2017 |
| SD Facilities Limited | Administrative & support | 2017 |
| SD Lease Limited | Hospitality | 2010 |
| SD Prestige Cars Ltd | Wholesale & retail | 2018 |
| SD Projects (South East) Limited | Construction | 2017 |
| SDK Optical Ltd | Wholesale & retail | 2024 |
| Sdks Properties Limited | Real estate | 2024 |
| SDS Civils Limited | Construction | 2019 |
| SE International Consult Ltd | Professional & scientific | 2024 |
| Sea Building Compliance Ltd | Professional & scientific | 2016 |
| Sea Dragon Ltd | Hospitality | 2017 |