| RRS Lettings Ltd | Real estate | 2022 |
| RSL Cityspace Limited | Information & communication | 1996 |
| Rslstreetnet Limited | Extraterritorial | 2011 |
| RSR Property Holdings Limited | Financial services | 2023 |
| Rudolph Software UK Ltd | Information & communication | 2016 |
| Russell Haines Limited | Administrative & support | 2003 |
| Ruth Bromley Limited | Wholesale & retail | 2012 |
| RVG Dawson Homes Ltd | Real estate | 2025 |
| S&G Midlands Ltd | Construction | 2024 |
| S&V Services Ltd | Construction | 2024 |
| S. Yeomans Limited | Professional & scientific | 2009 |
| S.E. Hart Ltd | Professional & scientific | 2014 |
| SA Corporate Communications Limited | Information & communication | 2015 |
| SA Torrassa Ltd | Professional & scientific | 2008 |
| Saas Creative Ltd | Professional & scientific | 2023 |
| Sabre Pet Food (UK) Limited | Wholesale & retail | 2024 |
| Sabre Services Ltd | Transport & logistics | 2015 |
| Salsbury Construction Limited | Construction | 2003 |
| Salsus Design Limited | Professional & scientific | 2013 |
| Salt Homes Limited | Real estate | 2019 |
| Samantha Harrison Development Consultant Limited | Professional & scientific | 2021 |
| Sangco Ltd | Real estate | 2022 |
| Sanjeevaa UK Limited | Information & communication | 2019 |
| Sanveygate Tyre Centre Limited | Wholesale & retail | 2013 |
| Sapava Ltd | Professional & scientific | 2021 |
| Sapphire Products Limited | Manufacturing | 1992 |
| Sargents Stripes Limited | Administrative & support | 2009 |
| SBM (Leicester) Limited | Construction | 2008 |
| SC Morgan Consulting Ltd | Professional & scientific | 2022 |
| Scale Model Scenery Limited | Manufacturing | 2014 |
| Scope (Jewellery) Limited | Manufacturing | 1979 |
| Scott CIP Limited | Administrative & support | 2018 |
| Scratchplay Limited | Information & communication | 2025 |
| Scribble Mail Limited | Professional & scientific | 2017 |
| Sden Solutions Ltd | Information & communication | 2012 |
| Second Base Systems Limited | Extraterritorial | 1989 |
| Selwyn Property Management Limited | Real estate | 2016 |
| Sensore Consulting Limited | Professional & scientific | 2016 |
| Sensory Design Limited | Wholesale & retail | 2025 |
| Servicemanager Limited | Extraterritorial | 1980 |
| SEW Wardrobe Limited | Other services | 2015 |
| Sewing School Limited | Administrative & support | 2021 |
| Sextons Group Limited | Extraterritorial | 1991 |
| Seymours (Derby) Limited | Hospitality | 2002 |
| SGM Creations Ltd | Arts & recreation | 2022 |
| Shanks Workwear Ltd | Manufacturing | 2026 |
| Sheen Parasport Ltd | Wholesale & retail | 2024 |
| Shellmac Limited | Information & communication | 2021 |
| Shellmac Property Ltd | Real estate | 2022 |
| Shelton Accounts Limited | Professional & scientific | 2021 |
| Shephard Building Services Ltd | Construction | 2008 |
| Sherwin & Bradbury Limited | Construction | 2002 |
| Sherwin Civil Engineering Limited | Construction | 2015 |
| Shores & Legal Limited | Administrative & support | 2019 |
| Simon Kimber Associates Limited | Information & communication | 2011 |
| Simon Pellecchia Fitness Ltd | Arts & recreation | 2025 |
| Simon Stanion Limited | Professional & scientific | 2011 |
| Simon Weeks Consultancy Limited | Professional & scientific | 2023 |
| Simonside Holdings Limited | Professional & scientific | 2023 |
| Simply Freedom Limited | Administrative & support | 2021 |
| Simply Healthcare Solutions Limited | Administrative & support | 2017 |
| Simpsons Cleaning Services Limited | Administrative & support | 2008 |
| Singularity Networks Limited | Administrative & support | 2018 |
| Sirimani Digital Solutions Limited | Information & communication | 2016 |
| SIX Ravens Ltd | Real estate | 2021 |
| SJ Topliss Ltd | Construction | 2025 |
| SJH Associates Ltd | Information & communication | 2024 |
| SJP Partner Services Limited | Health & social care | 2017 |
| Skpd Limited | Other services | 2021 |
| Skyward Coaching & Development Limited | Education | 2003 |
| Skywind Aviation Ltd | Transport & logistics | 2022 |
| SLB Financial Consultancy Limited | Professional & scientific | 2018 |
| SLR Enterprise Ltd | Wholesale & retail | 2024 |
| Smarter Managed Buildings Limited | Construction | 2021 |
| Smisby Woodlands Ltd | Agriculture & fishing | 2021 |
| Snowey Advice Ltd | Financial services | 2021 |
| Sofamakercouk Ltd | Manufacturing | 2025 |
| Soft Tech (England) Limited | Information & communication | 1996 |
| Soft Tech Europe Limited | Information & communication | 2000 |
| Software Agility Limited | Information & communication | 2013 |
| Sohe IT Consultancy Limited | Information & communication | 2018 |
| Solon Group Limited | Financial services | 2018 |
| Solum (UK) Ltd | Construction | 2014 |
| Sourcetech Ltd | Information & communication | 2003 |
| Special Property Solutions Ltd | Real estate | 2024 |
| Specialist Trackers UK Ltd | Administrative & support | 2023 |
| Spencer Sustainability Limited | Professional & scientific | 2026 |
| Spinney Construction Ltd | Construction | 2021 |
| Spinney Electrical Limited | Construction | 2018 |
| Spit Spot Media Limited | Information & communication | 2019 |
| Spitfire Collection Ltd | Manufacturing | 2022 |
| Split Air Conditioning Ltd | Energy | 2023 |
| Spondon M O T Centre Limited | Wholesale & retail | 2016 |
| Sports Therapy by Freya Ltd | Health & social care | 2026 |
| SPP Consulting UK Limited | Professional & scientific | 2007 |
| SPS Sourcing Ltd | Real estate | 2024 |
| SQ Equestrian Products Limited | Wholesale & retail | 1989 |
| Squirrel Investigation Training and Consultancy Ltd | Administrative & support | 2021 |
| SR. Trophy Limited | Wholesale & retail | 2021 |
| SRG Management Consultancy Ltd | Professional & scientific | 2022 |