| D.Rice Distribution Limited | Wholesale & retail | 2024 |
| D3M Trades Ltd | Information & communication | 2026 |
| DA Martin Ltd | Professional & scientific | 2017 |
| Dagama Ltd | Professional & scientific | 2021 |
| Dalton Art Ltd | Arts & recreation | 2024 |
| Daly Plant & Groundworks Ltd | Construction | 2026 |
| Damael Ltd | Wholesale & retail | 2026 |
| Damael Property Limited | Real estate | 2026 |
| Damian Mccann Cars & Vans Limited | Wholesale & retail | 2005 |
| Daniel Mccaffrey Ltd | Health & social care | 2015 |
| Dapper Dudes (N.I) Ltd | Wholesale & retail | 2015 |
| Dayton Group LP | | 2021 |
| Deborah Orme Limited | Information & communication | 2016 |
| Decent Simulators Limited | Manufacturing | 2022 |
| Decom Technology Ltd | Wholesale & retail | 2018 |
| Dekero & Co Ltd | Health & social care | 2026 |
| Delap & Waller International Ltd | Professional & scientific | 1995 |
| Delap & Waller Limited | Professional & scientific | 1987 |
| Denlyn Holdings Ltd | Professional & scientific | 2023 |
| Denzzy Dog Designs Ltd | Wholesale & retail | 2023 |
| Deskhand Ltd | Information & communication | 2025 |
| Devlin Plastering Limited | Construction | 2024 |
| DH Smart Car Body Repairs Ltd | Extraterritorial | 2024 |
| Dial a Dog Wash Antrim Ltd | Other services | 2024 |
| Dickson Scales Limited | Other services | 2019 |
| Diffusion Investments Limited | Financial services | 2014 |
| Divine Care and Support Services(Northern Ireland) Limited | Health & social care | 2023 |
| Divya Healthcare Ltd | Health & social care | 2023 |
| DJB Accounting Ltd | Professional & scientific | 2020 |
| Dmcg Consulting Group Ltd | Professional & scientific | 2021 |
| DMS Decorators (Antrim) Ltd | Construction | 2018 |
| DN Management Services (NI) Ltd | Other services | 2026 |
| Dobbin Property Services (DPS) Ltd | Real estate | 2023 |
| Dobson Keys Property LLP | | 2013 |
| Doherty Consulting Ltd | Professional & scientific | 2021 |
| Dokap Limited | Health & social care | 2022 |
| Dolmen Site Services Ltd | Administrative & support | 2019 |
| Donchary Limited | Health & social care | 2022 |
| Door Access Solutions Ltd | Construction | 2022 |
| Doorfix Ring-Gard Limited | Construction | 2010 |
| Double Chow Limited | Manufacturing | 2023 |
| Downtown Developments Limited | Real estate | 1970 |
| DPR Envelopcovers Ltd | Wholesale & retail | 2012 |
| Dream Wood Designs NI Ltd | Manufacturing | 2020 |
| Dreambig Recruitment Ltd | Administrative & support | 2026 |
| Dreamscape Enterprises Limited | Wholesale & retail | 2024 |
| Dreamstone Contracts Ltd | Construction | 2015 |
| Drenea Healthcare Ltd | Health & social care | 2023 |
| DROP-8 Life and Health Coaching Coaching Ltd | Health & social care | 2025 |
| DS Dreams Ltd | Wholesale & retail | 2024 |
| Dtlogistics Ltd | Transport & logistics | 2025 |
| Duneane Engineering Limited | Manufacturing | 2016 |
| Dunedin Management Services Limited | Professional & scientific | 2009 |
| Dunsilly Holdings Ltd | Financial services | 2021 |
| E.G. Freight Ltd | Transport & logistics | 2000 |
| East of Eden Furnitures Ltd | Manufacturing | 2019 |
| Ecko Global Ltd. | Professional & scientific | 2017 |
| Eden Property Let's Ltd | Households | 2024 |
| Egmc Property Ltd | Real estate | 2023 |
| EGO Death Ltd | Wholesale & retail | 2021 |
| EJR Properties Limited | Extraterritorial | 2025 |
| Elite Aesthetics and Skin Treatments Ltd | Health & social care | 2026 |
| Elite Competitions NI Ltd | Arts & recreation | 2025 |
| Elite Group Security Services NI Ltd | Administrative & support | 2022 |
| Elite Gym Academy CIC | Arts & recreation | 2020 |
| Ember L-Bridge Limited | Wholesale & retail | 2024 |
| Emdr Healing Ltd | Health & social care | 2026 |
| Emerald Experience Travel Ltd | Administrative & support | 2025 |
| Emerald Isle Recycle (Plastics) Ltd | Water & waste | 2010 |
| Emerald Isle Travel Ltd | Transport & logistics | 2026 |
| Emerson Sand & Gravel Limited | Mining & quarrying | 2006 |
| Emianna Ltd | Real estate | 2023 |
| Emma Louise Fashion Ltd | Wholesale & retail | 2026 |
| Empowering Communities Enterprise Limited | Administrative & support | 2017 |
| Enchanattu Homes Ltd | Real estate | 2025 |
| Energeia Technologies Limited | Administrative & support | 2005 |
| Ensite Creations Ltd | Real estate | 2023 |
| Entrepreneurs Unleashed Ltd | Professional & scientific | 2025 |
| Envirostore Tanks Limited | Manufacturing | 2016 |
| EOB Solutions Ltd | Professional & scientific | 2025 |
| Ernest Alexander Ltd | Professional & scientific | 2018 |
| Ethical Fundraising Solutions Limited | Other services | 2021 |
| Euphoria Beauty & Wellness Ltd | Other services | 2017 |
| Eurofire Systems Limited | Wholesale & retail | 2002 |
| Everway Opco Limited | Information & communication | 1996 |
| Evie Systems and Software Ltd | Professional & scientific | 2019 |
| Evolve Fitness Business Consultancy Ltd | Professional & scientific | 2021 |
| Evolve Health and Performance Ltd | Education | 2020 |
| Exact IT Resources Ltd | Information & communication | 2010 |
| Excelerate Systems Ltd | Professional & scientific | 2019 |
| Excelledia Ventures Limited | Information & communication | 2017 |
| Expnet Ltd | Administrative & support | 2021 |
| Exquisite Kitchens Ltd | Wholesale & retail | 2023 |
| F. O' Hara Contracts Ltd | Construction | 2005 |
| Facet Regen Ltd | Health & social care | 2026 |
| Fair Support Connecting Business Ltd | Other services | 2011 |
| Farm & Plant Machinery Ltd | Wholesale & retail | 2021 |
| Farm Life Limited | Wholesale & retail | 2012 |
| Farmer + Duffin Ltd | Construction | 2020 |
| Farmflix Limited | Information & communication | 2017 |