| Solway Climate Solutions Ltd | Construction | 2020 |
| Solway Clinics Ltd | Health & social care | 2015 |
| Solway Pest Control Limited | Agriculture & fishing | 2023 |
| Solway Properties Limited | Hospitality | 1978 |
| Solway Property Investments Ltd | Real estate | 2022 |
| Solway Property Management Ltd | Real estate | 2025 |
| Solway Seafoods Ltd | Agriculture & fishing | 2023 |
| Solway Spirits Ltd | Manufacturing | 2018 |
| Solway Swim & Leisure Limited | Other services | 2021 |
| South of Scotland Development Company Ltd | Construction | 2025 |
| Spotless Valet & Detailing Ltd | Administrative & support | 2020 |
| SSS (ROTCHELL17A) Ltd | Hospitality | 2023 |
| ST. James Smokehouse (Scotland) Limited | Manufacturing | 2004 |
| Star Dancers UK Ltd | Arts & recreation | 2018 |
| Strathaven Abattoir Limited | Professional & scientific | 1990 |
| T E Finishings Ltd | Construction | 2019 |
| T&L Nicholson Ltd | Agriculture & fishing | 2018 |
| T&T Projects Ltd | Construction | 2020 |
| T.I.M Forestry Limited | Agriculture & fishing | 2022 |
| T.N. Trawlers (Partnership) | | 2000 |
| Tarff Coffee Shop Limited | Hospitality | 2021 |
| Tartan Witch Ltd | Other services | 2022 |
| Taylor Accounting & Financial Management Limited | Real estate | 2016 |
| Tech Care Garage Ltd | Wholesale & retail | 2023 |
| Term Capital Limited | Administrative & support | 2023 |
| Texstress Ltd | Manufacturing | 2015 |
| TGP Logistics Limited | Wholesale & retail | 2017 |
| THE Barrasgate Farm Partnership | | 1997 |
| THE Bruce Garden Centre Limited | Wholesale & retail | 2025 |
| THE Commercial Inn (Annan) Ltd | Hospitality | 2025 |
| THE Corrieknowes Farm Partnership | | 2001 |
| THE D.R. Sloan (Backburn) Farm Partnership | | 1997 |
| THE Glow UP Club Ltd | Other services | 2026 |
| THE Henry Duncan Savings Bank Museum Limited | Arts & recreation | 2023 |
| THE Longfords Farm Partnership | | 1997 |
| THE New Milnfield Farm Partnership | | 2001 |
| THE New Nether Stenries Farm Partnership | | 2001 |
| THE Park Farm Partnership | | 2000 |
| THE Powfoot Golf Hotel (Annan) Limited | Hospitality | 2015 |
| THE Shed (D&G) Limited | Hospitality | 2020 |
| THE Shed Annan (AI) Ltd | Hospitality | 2017 |
| THE Solway Farm Partnership | | 1999 |
| Thomas Powley & SON Limited | Transport & logistics | 2005 |
| Thomson, Roddick & Laurie Limited | Other services | 1950 |
| Thorburn Funeral Directors Ltd | Other services | 2022 |
| TN Enterprises Ltd | Agriculture & fishing | 2016 |
| TN Trawlers Limited | Agriculture & fishing | 2002 |
| Todd Management Ltd | Real estate | 2020 |
| Triskelion.Electrical Ltd | Construction | 2025 |
| Turnberry Technical Solutions Ltd | Professional & scientific | 2020 |
| Two Amigos Pet Supplies Limited | Wholesale & retail | 2021 |
| Urban Cloud Vapes Ltd | Wholesale & retail | 2026 |
| Vaso Build Limited | Construction | 2023 |
| Vaso Global Limited | Financial services | 2023 |
| Vaso Manufacturing Limited | Manufacturing | 2025 |
| Vaso Technologies Limited | Professional & scientific | 2025 |
| Vivers Limited | Professional & scientific | 2010 |
| Vivers Scotlamb Limited | Manufacturing | 2008 |
| Wallace Logistics Ltd | Transport & logistics | 2024 |
| Watson Heating Service Plans Ltd | Construction | 2021 |
| Watson Plumbing & Heating Services Ltd | Construction | 2018 |
| Watson Plumbing Supplies Ltd | Wholesale & retail | 2023 |
| WIGTONVW25 Ltd | Wholesale & retail | 2025 |
| Wilson Assets Limited | Real estate | 2022 |
| Wilson Pets Limited | Wholesale & retail | 2021 |
| Windmore Concrete Products Limited | Manufacturing | 2011 |
| WNB Plant Limited | Construction | 2013 |
| Xperisense Ltd | Financial services | 2024 |
| Xtra Special (Scotland) Limited | Wholesale & retail | 2015 |
| Zaborowski D Ltd | Transport & logistics | 2018 |