| Encounters Education and Research Consultancy Ltd | Education | 2019 |
| Endeavour Hub AP Ltd | Education | 2025 |
| Endellion Limited | Professional & scientific | 2020 |
| Endental Limited | Health & social care | 2023 |
| Endodiabetes Health Ltd | Health & social care | 2025 |
| Enerfin Legal LAB LLP | | 2020 |
| Energy Compare Limited | Administrative & support | 2013 |
| Energy Flow Utilities Limited | Construction | 2021 |
| Energy Sector Developments Ltd | Professional & scientific | 2013 |
| Engage Topco Limited | Financial services | 2020 |
| Engaging Arts Ltd | Administrative & support | 2014 |
| Engineering Design (Altrincham) LLP | | 2016 |
| Enhance Medical Cheshire Ltd | Other services | 2024 |
| Enhanced Digital Limited | Information & communication | 2025 |
| Enjems Health & Harmony C.I.C. | Health & social care | 2025 |
| Enjoy Benefits Ltd | Professional & scientific | 2004 |
| Enjoy Payroll Limited | Administrative & support | 2016 |
| Enrich Emea Holding Limited | Professional & scientific | 2008 |
| Enrich Services Europe Limited | Professional & scientific | 2002 |
| Ensco 818 Limited | Extraterritorial | 2010 |
| ENT Aesthetics Ltd | Health & social care | 2025 |
| ENT Maxicare Ltd | Health & social care | 2025 |
| Entara Refining Ltd | Administrative & support | 2024 |
| Enterprise Site Management Ltd | Construction | 2014 |
| Enterprise Tax Consultants Limited | Professional & scientific | 2013 |
| Enthuse Cafe Limited | Hospitality | 2024 |
| Entire FS Ltd | Financial services | 2013 |
| Entire Property Holdings Ltd | Real estate | 2023 |
| Entwistle Green Limited | Professional & scientific | 2004 |
| Entwistle Jones Limited | Construction | 2006 |
| Enveil UK Limited | Information & communication | 2019 |
| Envero Group Limited | Manufacturing | 2022 |
| Enverstake Limited | Professional & scientific | 1979 |
| Enville Holdings Limited | Administrative & support | 2023 |
| Enviro Estates Limited | Extraterritorial | 2015 |
| Envirocore Limited | Water & waste | 2016 |
| Environmental Plastics Limited | Manufacturing | 2009 |
| Envo Holdco Limited | Professional & scientific | 2019 |
| Envo National Limited | Manufacturing | 2020 |
| Enya Moriarty Limited | Hospitality | 2025 |
| EP Medical Group Ltd | Manufacturing | 2021 |
| Ependys Marivers UK Ltd | Wholesale & retail | 2019 |
| Epik Marketing Limited | Professional & scientific | 2024 |
| Epiq Design Solutions UK Ltd | Wholesale & retail | 2023 |
| Eporter V Limited | Wholesale & retail | 2014 |
| Epsilon Telecommunications Limited | Information & communication | 2002 |
| Epsom Glass Industries Limited | Professional & scientific | 1992 |
| Equarisk Limited | Professional & scientific | 2025 |
| Equation Consulting Limited | Information & communication | 2010 |
| Equativ Ltd | Information & communication | 2022 |
| Equilibrium Pilates Education Ltd | Education | 2026 |
| Equinox Property Ltd | Real estate | 2018 |
| Equinox Surgery Ltd | Health & social care | 2025 |
| Equipoint Birmingham LP | | 2011 |
| Equis Associates Limited | Administrative & support | 2006 |
| Equity Advisory Limited | Administrative & support | 2013 |
| ERA Sports Ltd | Education | 2024 |
| Eram Intelligence Limited | Professional & scientific | 2026 |
| Erbanon Investments Limited | Financial services | 2014 |
| Erewhon Limited | Professional & scientific | 2025 |
| Ergo RTM Company Limited | Households | 2023 |
| Eric Trading Limited | Other services | 2013 |
| Eric Warburton(Plant & Machinery)Limited | Wholesale & retail | 1964 |
| Erie (GC) Holding Limited | Administrative & support | 2020 |
| Erie Finance 1 Limited | Extraterritorial | 2018 |
| Erie Finance 2 Limited | Extraterritorial | 2018 |
| Erie Finance Holding Limited | Extraterritorial | 2018 |
| Erie Finance Limited | Financial services | 2014 |
| Erie N2 UK Limited | Extraterritorial | 2018 |
| Erie U.K. Limited | Professional & scientific | 2001 |
| Erie UK 1 Limited | Professional & scientific | 2008 |
| Erie UK 2 Limited | Professional & scientific | 2008 |
| Erie UK 3 Limited | Extraterritorial | 2018 |
| Erie UK 4 Limited | Extraterritorial | 2018 |
| Erie UK 5 Limited | Extraterritorial | 2018 |
| Erie UK 6 Limited | Extraterritorial | 2023 |
| Erie UK Senior Holding Limited | Professional & scientific | 2008 |
| Eriksson Baker Associates Limited | Information & communication | 2025 |
| Erimax Ltd | Professional & scientific | 2011 |
| Erinmerylstudy Ltd | Information & communication | 2025 |
| Erintech IT Solutions Limited | Professional & scientific | 2025 |
| Ermatters Limited | Administrative & support | 2024 |
| Ernest Shaw Limited | Information & communication | 2010 |
| ERP Gurus Limited | Professional & scientific | 2020 |
| Erply Limited | Administrative & support | 2009 |
| Erucan Properties Ltd | Real estate | 2025 |
| Erugs Ltd | Wholesale & retail | 2023 |
| ES Consult Limited | Administrative & support | 2016 |
| Esako Group Ltd | Other services | 2025 |
| Esako Limited | Real estate | 2024 |
| Escape the Van Ltd | Arts & recreation | 2017 |
| Escapesea Limited | Administrative & support | 2026 |
| Escientia Securitas Limited | Manufacturing | 2024 |
| Esdigi Consulting Limited | Information & communication | 2023 |
| Eshefa Ltd | Professional & scientific | 2017 |
| Eshermore Limited | Professional & scientific | 2024 |
| Eshez Ltd | Other services | 2023 |
| Eskuisiti Ltd | Transport & logistics | 2020 |
| Esme Optical Ltd | Health & social care | 2012 |
| Esmie Management Ltd | Real estate | 2025 |