| Urbano Red Limited | Construction | 2021 |
| Urbansense Holdings Limited | Construction | 2017 |
| Urct Ltd | Wholesale & retail | 2024 |
| Ured Safety Solutions Limited | Professional & scientific | 2026 |
| Urlocaltechguy Limited | Information & communication | 2024 |
| Urmston Beverage & Leisure Company Limited | Other services | 2017 |
| Urmston Property Ltd | Real estate | 2022 |
| Urotec Limited | Professional & scientific | 1997 |
| US Holdings Limited | Real estate | 2022 |
| US Merchants UK Company, Ltd. | Professional & scientific | 2024 |
| USE OUR Space Limited | Real estate | 2020 |
| USE That Space Limited | Construction | 2010 |
| Used Furniture Solutions Limited | Wholesale & retail | 2013 |
| User Research Consulting Limited | Administrative & support | 2025 |
| Usmania Function Hall Ltd | Hospitality | 2021 |
| Usual Expat Limited | Wholesale & retail | 2023 |
| Utility Meters Holdings Limited | Wholesale & retail | 2022 |
| Utility Therapeutics Ltd | Professional & scientific | 2017 |
| UTR Capital Limited | Professional & scientific | 2023 |
| Uveitis & Retina Ltd | Health & social care | 2025 |
| UW Investments Limited | Real estate | 2015 |
| UX Helps Limited | Information & communication | 2016 |
| Uxrinsight Limited | Administrative & support | 2024 |
| Uzooris Ltd | Health & social care | 2022 |
| Uzziel Healthcare Limited | Health & social care | 2024 |
| V a a Investment Ltd | Real estate | 2020 |
| V Opco Group UK Limited | Wholesale & retail | 2019 |
| V.T.M. Construction Limited | Construction | 2018 |
| V2 LED Ltd | Professional & scientific | 2018 |
| V2A Care Ltd | Health & social care | 2023 |
| V4 Holdings Limited | Professional & scientific | 2012 |
| V4 Services Limited | Professional & scientific | 2008 |
| V4 UK Holdings Limited | Professional & scientific | 2016 |
| V4UMANCHESTER Limited | Administrative & support | 2026 |
| Vaccitech Oncology Limited | Professional & scientific | 2018 |
| Vaikunta Global Limited | Wholesale & retail | 2024 |
| Valdamark Ltd | Wholesale & retail | 2011 |
| Vale Funding Limited | Administrative & support | 2009 |
| Valehouse Investments Limited | Real estate | 2024 |
| Valencia Sun Limited | Professional & scientific | 2020 |
| Valero Consulting Limited | Professional & scientific | 2023 |
| VALID8 IP Ltd | Information & communication | 2017 |
| Valient LLP | | 2007 |
| Valle Ltd | Wholesale & retail | 2005 |
| Valley Consultants Limited | Professional & scientific | 2012 |
| Valtav Limited | Administrative & support | 2009 |
| Valterra Land Limited | Construction | 2025 |
| Valve Accessories and Controls Limited | Manufacturing | 2005 |
| Valyrian Advisors Limited | Administrative & support | 2016 |
| Van Rees Limited | Wholesale & retail | 1956 |
| Vanet Property Asset Management Limited | Professional & scientific | 2006 |
| Vangarde Limited | Construction | 2023 |
| Vaniak Holdings Limited | Real estate | 2023 |
| Vansky Solutions Limited | Administrative & support | 2014 |
| Vantage Building Consultancy Limited | Professional & scientific | 2015 |
| Vantaloom Limited | Professional & scientific | 2024 |
| Varcas Ltd | Professional & scientific | 2024 |
| Varcoe Eyecare Ltd | Health & social care | 2019 |
| Various Productions Ltd | Arts & recreation | 2012 |
| Varley Electrical Services Limited | Professional & scientific | 2010 |
| Varndean Holt Limited | Administrative & support | 2003 |
| Varso Limited | Information & communication | 2025 |
| Vasco Medics International Ltd | Administrative & support | 2018 |
| Vasco Medix PVT Ltd | Health & social care | 2017 |
| Vatic UK LLP | | 2023 |
| Vatradingsuk Ltd | Wholesale & retail | 2025 |
| Vaughancoleman Ltd | Health & social care | 2026 |
| Vaxbio Ltd | Professional & scientific | 2019 |
| Vazon Bay Limited | Professional & scientific | 2014 |
| VB Cardiff Ltd | Real estate | 2024 |
| VB Trading Ltd | Hospitality | 2024 |
| Vbox IT Ltd | Information & communication | 2014 |
| VBS Tech Limited | Information & communication | 2015 |
| VC Drilling Ltd | Construction | 2019 |
| Vcube Tech Solutions Ltd | Information & communication | 2023 |
| Vcvi Holdings Ltd | Financial services | 2026 |
| Vcvi Ltd | Financial services | 2026 |
| VD DV Ltd | Construction | 2025 |
| Vdental Limited | Health & social care | 2024 |
| Vdwf Limited | Administrative & support | 2024 |
| Vecapital Property Company Limited | Financial services | 2018 |
| Vectis Bidco Limited | Financial services | 2025 |
| Vectis Midco 2 Limited | Financial services | 2025 |
| Vectis Midco 3 Limited | Financial services | 2025 |
| Vector Ledger Limited | Information & communication | 2026 |
| VEE Trading Ltd | Other services | 2023 |
| Vegex Ltd | Hospitality | 2004 |
| Vehicle Technical Solutions Ltd | Wholesale & retail | 2022 |
| Veil and VÉU Limited | Hospitality | 2023 |
| Veloce Spares Limited | Manufacturing | 1977 |
| Velocity Global International Services Ltd | Administrative & support | 2017 |
| Velocity Green Lean Ltd | Professional & scientific | 2012 |
| Velocity Green Property Ltd | Real estate | 2022 |
| Velocity Lean Ltd | Extraterritorial | 2020 |
| Velocity Technology Holdings Limited | Financial services | 2025 |
| Velocity Technology Limited | Financial services | 2025 |
| Velocity Trading Partners Limited | Financial services | 2026 |
| Velocity UK Holdings Limited | Financial services | 2021 |
| Veltron Engineering Service Limited | Professional & scientific | 2026 |
| Velvet Orion Ltd | Wholesale & retail | 2026 |