| Sunny Mountain Ltd | Hospitality | 2021 |
| Sunny Odumade Limited | Health & social care | 2009 |
| Sunny Thinking Limited | Professional & scientific | 2008 |
| Sunnyside Fusion Kitchen Ltd | Hospitality | 2020 |
| SUNNYWAY88 Limited | Hospitality | 2021 |
| Sunrise ERP Ltd | Wholesale & retail | 2025 |
| Sunrise Global Services Limited | Real estate | 2021 |
| Sunshine Consultancy Limited | Professional & scientific | 2020 |
| Sunshine Tsang Properties Limited Limited | Real estate | 2024 |
| SUNSHINE88 Ltd | Real estate | 2026 |
| Sunsol Limited | Professional & scientific | 2017 |
| Supa Sympa Limited | Administrative & support | 2013 |
| Supaglaze Holdings Limited | Financial services | 2017 |
| Supaglaze Properties Limited | Real estate | 2014 |
| Super Phones Limited | Wholesale & retail | 2008 |
| Superchain Labs Limited | Information & communication | 2022 |
| Supernova UK Holdings Limited | Financial services | 2024 |
| Superwear Ltd | Wholesale & retail | 2019 |
| Supply Chain Software Limited | Information & communication | 2025 |
| Supply Chain United Limited | Professional & scientific | 2018 |
| Support Services Limited | Professional & scientific | 2025 |
| Sure Supply Limited | Information & communication | 2023 |
| Surgery Assist Ltd | Health & social care | 2014 |
| Surgery Developments Limited | Real estate | 2000 |
| Surgical Excellence Ltd | Health & social care | 2026 |
| Suriya Enterprise Limited | Households | 2025 |
| Surrealdb Ltd | Information & communication | 2021 |
| Survcomm Ltd | Professional & scientific | 2020 |
| Survey HUT (Franchise) Limited | Professional & scientific | 2024 |
| Survey HUT Limited | Professional & scientific | 2021 |
| Survey Studio Ltd | Professional & scientific | 2020 |
| Susan J Filson Physiotherapy Consultancy Limited | Professional & scientific | 2013 |
| Sushila Apex Mart Limited | Wholesale & retail | 2025 |
| Sustainable Health Solutions Limited | Health & social care | 2026 |
| Sutcliffe Road Fraser Homes Limited | Construction | 2022 |
| Suthir & Kaur Consultants Limited | Professional & scientific | 2026 |
| Sutton Kersh Holdings Ltd | Professional & scientific | 2013 |
| Suzamar Consulting Ltd | Information & communication | 2017 |
| Suzani Ltd | Wholesale & retail | 2025 |
| Suzie MB Limited | Health & social care | 2021 |
| Suzy Plus Limited | Wholesale & retail | 2007 |
| SV Dental Ltd | Health & social care | 2022 |
| SV63 Ltd | Administrative & support | 2025 |
| SVA Technologies Limited | Administrative & support | 2017 |
| Svedbergs UK Limited | Financial services | 2021 |
| Svinc Solutions Ltd | Information & communication | 2019 |
| SVM Homes Ltd | Real estate | 2026 |
| Svpuk Properties Ltd | Real estate | 2026 |
| Swain Construction Ltd | Construction | 2019 |
| Swakefield East Ltd | Health & social care | 2024 |
| Swan (IT) Ltd | Arts & recreation | 2013 |
| Swan Endosurgical UK Limited | Professional & scientific | 2025 |
| Swan Hill Homes Limited | Real estate | 1964 |
| Swan Hill Share Scheme Trustees Limited | Professional & scientific | 1993 |
| Swank Limited | Professional & scientific | 2024 |
| Swaraj Properties Limited | Real estate | 2016 |
| Swaraj Technologies Limited | Information & communication | 2011 |
| Swarbrick Research Limited | Education | 2012 |
| Sweet Caroline (Hale) Ltd | Wholesale & retail | 2025 |
| Swest Financial Limited | Financial services | 2018 |
| Swifft Publications Limited | Information & communication | 2005 |
| Swift IT Consulting Ltd | Information & communication | 2022 |
| Swift Racket Sports Ltd | Arts & recreation | 2024 |
| Swiftbulk Holding Co. Limited | Financial services | 2018 |
| Swiftflight Avionics Limited | Professional & scientific | 2016 |
| Swifttankers Holding Co. Ltd. | Financial services | 2019 |
| Swinnyproperty Ltd | Real estate | 2026 |
| Swinton Property Limited | Real estate | 2024 |
| Swissuk Education Holdings Limited | Education | 2024 |
| Swor Limited | Health & social care | 2024 |
| Swyambhu Ltd | Hospitality | 2026 |
| Syed Raza Properties Ltd | Real estate | 2023 |
| Sygaren Development Ltd | Real estate | 2021 |
| Sykes Cottages EBT Limited | Extraterritorial | 2016 |
| Sykes Cottages Holdings Limited | Financial services | 2014 |
| Sykes Oncology Ltd | Health & social care | 2010 |
| Sylvan Avenue (Management) Limited | Households | 2000 |
| Sylvon Limited | Professional & scientific | 2017 |
| Sym-Sys Ltd | Information & communication | 2014 |
| Symbotic Systems UK Ltd. | Manufacturing | 2023 |
| Symonds Consultancy Ltd | Professional & scientific | 2024 |
| Symons & Spark Limited | Administrative & support | 2016 |
| Synapse and Sphere LAB Limited | Professional & scientific | 2026 |
| Synaptive Consulting Ltd | Professional & scientific | 2025 |
| Synapze Ltd | Real estate | 2014 |
| Synara Access Limited | Administrative & support | 2026 |
| Synbiotix Limited | Extraterritorial | 2018 |
| Synbiotix Solutions Limited | Information & communication | 2008 |
| Sync Sound Limited | Information & communication | 2000 |
| Synergise Consultants Limited | Professional & scientific | 2024 |
| Synergy (Towers) Management Company Limited | Households | 2007 |
| Synergy Cloud Solutions Limited | Information & communication | 2015 |
| Synergy Comms Limited | Information & communication | 2015 |
| Synergy Dental Care Ltd | Health & social care | 2009 |
| Synergy Process Solutions Limited | Professional & scientific | 2018 |
| Synergy TS Limited | Information & communication | 2015 |
| Synetic Limited | Professional & scientific | 2022 |
| Synstack Ltd | Information & communication | 2026 |
| Syntax Solutions Limited | Information & communication | 2006 |
| Synthesis Design & Visualisation Limited | Professional & scientific | 1999 |